Insulin-like growth factors, insulin-like growth factor-binding proteins, and endometrial cancer in postmenopausal women: Results from a U.S. case-control study

James V. Lacey, Nancy Potischman, M. Patricia Madigan, Michael L. Berman, Rodrigue Mortel, Leo B. Twiggs, Rolland J. Barrett, George D. Wilbanks, John R. Lurain, Capri Mara Fillmore, Mark E. Sherman, Louise A. Brinton

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31 Scopus citations

Abstract

Objective: To assess whether circulating insulin-like growth factor-1 (IGF-1), IGF-2, insulin-like growth factor-binding protein-1 (IGFBP-1), or IGFBP-3 were associated with endometrial cancer in postmenopausal women. Study Design: Between 1987 and 1990, we conducted a case-control study of 405 women with endometrial cancer and 297 matched population-based controls. This analysis included 174 postmenopausal cases and 136 controls. Results: In logistic regression models adjusted for potential confounders, higher IGF-1 levels were not positively associated with endometrial cancer: odds ratio (OR) for the highest tertile versus the lowest tertile = 0.63, 95% confidence interval (CI) = 0.30-1.32. Endometrial cancer was inversely associated with IGF-2 (OR for the highest tertile = 0.35, 95% CI = 0.18-0.69) and IGFBP-3 (OR for the highest tertile = 0.40, 95% CI = 0.21-0.77), and not associated with IGFBP-1. Conclusion: Serum IGF-1, IGF-2, and IGFBP-3, but not IGFBP-1, were inversely associated with endometrial cancer in postmenopausal women. These associations and the potential role of the IGF system in endometrial proliferation and carcinogenesis warrant further research.

Original languageEnglish (US)
Pages (from-to)607-612
Number of pages6
JournalCancer Epidemiology Biomarkers and Prevention
Volume13
Issue number4
StatePublished - Apr 2004

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ASJC Scopus subject areas

  • Epidemiology
  • Oncology

Cite this

Lacey, J. V., Potischman, N., Madigan, M. P., Berman, M. L., Mortel, R., Twiggs, L. B., Barrett, R. J., Wilbanks, G. D., Lurain, J. R., Fillmore, C. M., Sherman, M. E., & Brinton, L. A. (2004). Insulin-like growth factors, insulin-like growth factor-binding proteins, and endometrial cancer in postmenopausal women: Results from a U.S. case-control study. Cancer Epidemiology Biomarkers and Prevention, 13(4), 607-612.