Insulin and interleukin-4 induce desensitization to the mitogenic effects of insulin-like growth factor-i: Pivotal role for insulin receptor substrate-2

Medicine & Life Sciences

• Insulin Receptor Substrate Proteins 100%
• Somatomedins 81%
• Interleukin-4 71%
• Insulin-Like Growth Factor I 63%
• Insulin 52%
• Cattle 22%
• Fibroblasts 20%
• Cytokine Receptors 16%
• 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 16%
• Phosphorylation 14%
• Phosphatidylinositol 3-Kinase 14%
• Antibodies 11%
• Interleukin-4 Receptors 10%
• Phosphotyrosine 8%
• IGF Type 1 Receptor 8%
• 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 8%
• Growth Factor Receptors 8%
• Insulin Receptor 7%
• DNA 7%
• Receptor Protein-Tyrosine Kinases 7%
• Protein Kinase Inhibitors 7%
• Immunoblotting 6%
• Tyrosine 6%
• Anti-Idiotypic Antibodies 5%
• Hormones 4%
• Growth 3%
• Proteins 2%

Chemical Compounds

• Insulin Derivative 78%
• LY294002 18%
• Tyrosine 9%
• Growth Factor 6%
• Molecular Mass 4%
• Protein 4%
• Metabolic 4%