Innate resistance to Babesia infection is influenced by genetic background and gender

I. Aguilar-Delfin, M. J. Homer, P. J. Wettstein, D. H. Persing

Research output: Contribution to journalArticle

32 Scopus citations

Abstract

Infection of severe combined immunodeficient mice with Babesia sp. strain WA1 was studied to assess the contributions of innate and adaptive immunity in resistance to acute babesiosis. The scid mutation showed little effect in genetically susceptible C3H mice and did not decrease the inherent resistance of C57BL/6 mice to the infection, suggesting that innate immunity plays a central role in determining the course of Babesia infection in these strains. In contrast, the scid mutation dramatically impaired resistance in moderately susceptible BALB/c mice, suggesting that acquired immunity may play an important secondary role. In comparison to their female counterparts, male mice of different genetic backgrounds showed increased resistance to the infection, indicating that the gender of the host may influence protection against babesiosis.

Original languageEnglish (US)
Pages (from-to)7955-7958
Number of pages4
JournalInfection and Immunity
Volume69
Issue number12
DOIs
StatePublished - 2001

ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Immunology
  • Infectious Diseases

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