Inhibition of glycogen synthase kinase-3

Andrei V. Ougolkov, Daniel D. Billadeau

Research output: Chapter in Book/Report/Conference proceedingChapter

16 Scopus citations

Abstract

There are two homologous forms of glycogen synthase kinase (GSK)-3, GSK-3α and GSK-3β, which play overlapping roles in the regulation of Wnt, Hedgehog, and insulin pathways, as well as the activation of nuclear factor (NF)-kB-mediated gene transcription. These signaling pathways regulate gene transcription, cell cycle, apoptosis, inflammation, glucose metabolism, stem-cell renewal, and differentiation. More than 50 GSK-3 inhibitors representing a wide range of chemical structures have already been identified, and their utility in the treatment of type II diabetes mellitus, Alzheimer's disease, bipolar diseases, cancer, and other human pathologies is currently being investigated. Here, we discuss two methods of GSK-3 inhibition, which can be used to determine the involvement of GSK-3 in a cellular process of interest.

Original languageEnglish (US)
Title of host publicationWnt Signaling
Subtitle of host publicationPathway Methods and Mammalian Models
EditorsElizabeth Vincan
Pages67-75
Number of pages9
DOIs
StatePublished - Dec 1 2008

Publication series

NameMethods in Molecular Biology
Volume468
ISSN (Print)1064-3745

Keywords

  • Glycogen synthase
  • Glycogen synthase kinase-3
  • β-catenin

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

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  • Cite this

    Ougolkov, A. V., & Billadeau, D. D. (2008). Inhibition of glycogen synthase kinase-3. In E. Vincan (Ed.), Wnt Signaling: Pathway Methods and Mammalian Models (pp. 67-75). (Methods in Molecular Biology; Vol. 468). https://doi.org/10.1007/978-1-59745-249-6_5