TY - CHAP
T1 - Inhibition of glycogen synthase kinase-3
AU - Ougolkov, Andrei V.
AU - Billadeau, Daniel D.
PY - 2008
Y1 - 2008
N2 - There are two homologous forms of glycogen synthase kinase (GSK)-3, GSK-3α and GSK-3β, which play overlapping roles in the regulation of Wnt, Hedgehog, and insulin pathways, as well as the activation of nuclear factor (NF)-kB-mediated gene transcription. These signaling pathways regulate gene transcription, cell cycle, apoptosis, inflammation, glucose metabolism, stem-cell renewal, and differentiation. More than 50 GSK-3 inhibitors representing a wide range of chemical structures have already been identified, and their utility in the treatment of type II diabetes mellitus, Alzheimer's disease, bipolar diseases, cancer, and other human pathologies is currently being investigated. Here, we discuss two methods of GSK-3 inhibition, which can be used to determine the involvement of GSK-3 in a cellular process of interest.
AB - There are two homologous forms of glycogen synthase kinase (GSK)-3, GSK-3α and GSK-3β, which play overlapping roles in the regulation of Wnt, Hedgehog, and insulin pathways, as well as the activation of nuclear factor (NF)-kB-mediated gene transcription. These signaling pathways regulate gene transcription, cell cycle, apoptosis, inflammation, glucose metabolism, stem-cell renewal, and differentiation. More than 50 GSK-3 inhibitors representing a wide range of chemical structures have already been identified, and their utility in the treatment of type II diabetes mellitus, Alzheimer's disease, bipolar diseases, cancer, and other human pathologies is currently being investigated. Here, we discuss two methods of GSK-3 inhibition, which can be used to determine the involvement of GSK-3 in a cellular process of interest.
KW - Glycogen synthase
KW - Glycogen synthase kinase-3
KW - β-catenin
UR - http://www.scopus.com/inward/record.url?scp=58749098455&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=58749098455&partnerID=8YFLogxK
U2 - 10.1007/978-1-59745-249-6_5
DO - 10.1007/978-1-59745-249-6_5
M3 - Chapter
C2 - 19099246
AN - SCOPUS:58749098455
SN - 9781588299123
T3 - Methods in Molecular Biology
SP - 67
EP - 75
BT - Wnt Signaling
A2 - Vincan, Elizabeth
ER -