Inhibition of electrically induced seizures by a dihydropyridine calcium channel blocker

Fredric B. Meyer; Philip W. Tally; Robert E. Anderson; Thoralf M. Sundt; Tony L. Yaksh; Frank W. Sharbrough

doi:10.1016/0006-8993(86)91236-9

Inhibition of electrically induced seizures by a dihydropyridine calcium channel blocker

Fredric B. Meyer, Philip W. Tally, Robert E. Anderson, Thoralf M. Sundt, Tony L. Yaksh, Frank W. Sharbrough

Neurosurgery

Research output: Contribution to journal › Article › peer-review

56 Scopus citations

Abstract

Nimodipine, a calcium channel blocker with high affinity for central dihydropyridine Ca²⁺ channels, produced a dose-dependent suppression of electrically induced seizures in the rabbit. Verapamil, a diphenylalkylamine which acts at peripheral Ca²⁺ channels, was ineffective. Phenytoin was less effective than nimodipine. These results suggest that calcium flux into neurons may be a biochemical precipitant for seizure genesis. Centrally acting calcium channel blockers may prove to be a new class of anticonvulsants.

Original language	English (US)
Pages (from-to)	180-183
Number of pages	4
Journal	Brain Research
Volume	384
Issue number	1
DOIs	https://doi.org/10.1016/0006-8993(86)91236-9
State	Published - Oct 1 1986

Keywords

Calcium channel blocker
Dihydropyridine
Nimodipine
Phenytoin
Seizure

ASJC Scopus subject areas

General Neuroscience
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/0006-8993(86)91236-9

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title = "Inhibition of electrically induced seizures by a dihydropyridine calcium channel blocker",

abstract = "Nimodipine, a calcium channel blocker with high affinity for central dihydropyridine Ca2+ channels, produced a dose-dependent suppression of electrically induced seizures in the rabbit. Verapamil, a diphenylalkylamine which acts at peripheral Ca2+ channels, was ineffective. Phenytoin was less effective than nimodipine. These results suggest that calcium flux into neurons may be a biochemical precipitant for seizure genesis. Centrally acting calcium channel blockers may prove to be a new class of anticonvulsants.",

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T1 - Inhibition of electrically induced seizures by a dihydropyridine calcium channel blocker

AU - Meyer, Fredric B.

AU - Tally, Philip W.

AU - Anderson, Robert E.

AU - Sundt, Thoralf M.

AU - Yaksh, Tony L.

AU - Sharbrough, Frank W.

PY - 1986/10/1

Y1 - 1986/10/1

N2 - Nimodipine, a calcium channel blocker with high affinity for central dihydropyridine Ca2+ channels, produced a dose-dependent suppression of electrically induced seizures in the rabbit. Verapamil, a diphenylalkylamine which acts at peripheral Ca2+ channels, was ineffective. Phenytoin was less effective than nimodipine. These results suggest that calcium flux into neurons may be a biochemical precipitant for seizure genesis. Centrally acting calcium channel blockers may prove to be a new class of anticonvulsants.

AB - Nimodipine, a calcium channel blocker with high affinity for central dihydropyridine Ca2+ channels, produced a dose-dependent suppression of electrically induced seizures in the rabbit. Verapamil, a diphenylalkylamine which acts at peripheral Ca2+ channels, was ineffective. Phenytoin was less effective than nimodipine. These results suggest that calcium flux into neurons may be a biochemical precipitant for seizure genesis. Centrally acting calcium channel blockers may prove to be a new class of anticonvulsants.

KW - Calcium channel blocker

KW - Dihydropyridine

KW - Nimodipine

KW - Phenytoin

KW - Seizure

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Inhibition of electrically induced seizures by a dihydropyridine calcium channel blocker

Abstract

Keywords

ASJC Scopus subject areas

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