Inhibition of electrically induced seizures by a dihydropyridine calcium channel blocker

Fredric B. Meyer, Philip W. Tally, Robert E. Anderson, Thoralf M. Sundt, Tony L. Yaksh, Frank W. Sharbrough

Research output: Contribution to journalArticle

56 Citations (Scopus)

Abstract

Nimodipine, a calcium channel blocker with high affinity for central dihydropyridine Ca2+ channels, produced a dose-dependent suppression of electrically induced seizures in the rabbit. Verapamil, a diphenylalkylamine which acts at peripheral Ca2+ channels, was ineffective. Phenytoin was less effective than nimodipine. These results suggest that calcium flux into neurons may be a biochemical precipitant for seizure genesis. Centrally acting calcium channel blockers may prove to be a new class of anticonvulsants.

Original languageEnglish (US)
Pages (from-to)180-183
Number of pages4
JournalBrain Research
Volume384
Issue number1
DOIs
StatePublished - Oct 1 1986

Fingerprint

Nimodipine
Calcium Channel Blockers
Seizures
Phenytoin
Verapamil
Anticonvulsants
Rabbits
Calcium
Neurons
1,4-dihydropyridine

Keywords

  • Calcium channel blocker
  • Dihydropyridine
  • Nimodipine
  • Phenytoin
  • Seizure

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Meyer, F. B., Tally, P. W., Anderson, R. E., Sundt, T. M., Yaksh, T. L., & Sharbrough, F. W. (1986). Inhibition of electrically induced seizures by a dihydropyridine calcium channel blocker. Brain Research, 384(1), 180-183. https://doi.org/10.1016/0006-8993(86)91236-9

Inhibition of electrically induced seizures by a dihydropyridine calcium channel blocker. / Meyer, Fredric B.; Tally, Philip W.; Anderson, Robert E.; Sundt, Thoralf M.; Yaksh, Tony L.; Sharbrough, Frank W.

In: Brain Research, Vol. 384, No. 1, 01.10.1986, p. 180-183.

Research output: Contribution to journalArticle

Meyer, FB, Tally, PW, Anderson, RE, Sundt, TM, Yaksh, TL & Sharbrough, FW 1986, 'Inhibition of electrically induced seizures by a dihydropyridine calcium channel blocker', Brain Research, vol. 384, no. 1, pp. 180-183. https://doi.org/10.1016/0006-8993(86)91236-9
Meyer FB, Tally PW, Anderson RE, Sundt TM, Yaksh TL, Sharbrough FW. Inhibition of electrically induced seizures by a dihydropyridine calcium channel blocker. Brain Research. 1986 Oct 1;384(1):180-183. https://doi.org/10.1016/0006-8993(86)91236-9
Meyer, Fredric B. ; Tally, Philip W. ; Anderson, Robert E. ; Sundt, Thoralf M. ; Yaksh, Tony L. ; Sharbrough, Frank W. / Inhibition of electrically induced seizures by a dihydropyridine calcium channel blocker. In: Brain Research. 1986 ; Vol. 384, No. 1. pp. 180-183.
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