Inhibition of electrically induced seizures by a dihydropyridine calcium channel blocker

Fredric B. Meyer, Philip W. Tally, Robert E. Anderson, Thoralf M. Sundt, Tony L. Yaksh, Frank W. Sharbrough

Research output: Contribution to journalArticle

56 Scopus citations

Abstract

Nimodipine, a calcium channel blocker with high affinity for central dihydropyridine Ca2+ channels, produced a dose-dependent suppression of electrically induced seizures in the rabbit. Verapamil, a diphenylalkylamine which acts at peripheral Ca2+ channels, was ineffective. Phenytoin was less effective than nimodipine. These results suggest that calcium flux into neurons may be a biochemical precipitant for seizure genesis. Centrally acting calcium channel blockers may prove to be a new class of anticonvulsants.

Original languageEnglish (US)
Pages (from-to)180-183
Number of pages4
JournalBrain Research
Volume384
Issue number1
DOIs
StatePublished - Oct 1 1986

Keywords

  • Calcium channel blocker
  • Dihydropyridine
  • Nimodipine
  • Phenytoin
  • Seizure

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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    Meyer, F. B., Tally, P. W., Anderson, R. E., Sundt, T. M., Yaksh, T. L., & Sharbrough, F. W. (1986). Inhibition of electrically induced seizures by a dihydropyridine calcium channel blocker. Brain Research, 384(1), 180-183. https://doi.org/10.1016/0006-8993(86)91236-9