Abstract
Previous studies have demonstrated that both the antibody and T-lymphocyte proliferative immune responses to poly(Glu 53Lys 36Phe 11)(n) (GLΦ) are under the control of two major histocompatibility-linked immune response (Ir) genes. One gene, termed Ir-GLΦ-α, has been mapped to the I-C or I-E subregion of the major histocompatibility complex, while the other, termed Ir-CLΦ-β, has been mapped to the I-A subregion. In this paper we examine the effect of anti-I-region-associated (Ia) antisera on the T-lymphocyte proliferative response to GLΦ. Antibodies directed against Ia antigens coded for by genes in either the I-A or I-C subregion were found to inhibit the proliferative response to GLΦ. These results suggest that a function mediated by two Ir gene products can be blocked by anti-Ia antisera directed against either one, and thus, that both products are expressed on the cell surface.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 2387-2391 |
| Number of pages | 5 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Volume | 75 |
| Issue number | 5 |
| State | Published - 1978 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Genetics
- General
Cite this
Inhibition of dual Ir gene-controlled T-lymphocyte proliferative response to poly(Glu 56Lys 35Phe 9)(n) with anti-Ia antisera directed against products of either I-A or I-C subregion. / Schwartz, R. H.; David, C. S.; Dorf, M. E.; Benacerraf, B.; Paul, W. E.
In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 75, No. 5, 1978, p. 2387-2391.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Inhibition of dual Ir gene-controlled T-lymphocyte proliferative response to poly(Glu 56Lys 35Phe 9)(n) with anti-Ia antisera directed against products of either I-A or I-C subregion
AU - Schwartz, R. H.
AU - David, C. S.
AU - Dorf, M. E.
AU - Benacerraf, B.
AU - Paul, W. E.
PY - 1978
Y1 - 1978
N2 - Previous studies have demonstrated that both the antibody and T-lymphocyte proliferative immune responses to poly(Glu 53Lys 36Phe 11)(n) (GLΦ) are under the control of two major histocompatibility-linked immune response (Ir) genes. One gene, termed Ir-GLΦ-α, has been mapped to the I-C or I-E subregion of the major histocompatibility complex, while the other, termed Ir-CLΦ-β, has been mapped to the I-A subregion. In this paper we examine the effect of anti-I-region-associated (Ia) antisera on the T-lymphocyte proliferative response to GLΦ. Antibodies directed against Ia antigens coded for by genes in either the I-A or I-C subregion were found to inhibit the proliferative response to GLΦ. These results suggest that a function mediated by two Ir gene products can be blocked by anti-Ia antisera directed against either one, and thus, that both products are expressed on the cell surface.
AB - Previous studies have demonstrated that both the antibody and T-lymphocyte proliferative immune responses to poly(Glu 53Lys 36Phe 11)(n) (GLΦ) are under the control of two major histocompatibility-linked immune response (Ir) genes. One gene, termed Ir-GLΦ-α, has been mapped to the I-C or I-E subregion of the major histocompatibility complex, while the other, termed Ir-CLΦ-β, has been mapped to the I-A subregion. In this paper we examine the effect of anti-I-region-associated (Ia) antisera on the T-lymphocyte proliferative response to GLΦ. Antibodies directed against Ia antigens coded for by genes in either the I-A or I-C subregion were found to inhibit the proliferative response to GLΦ. These results suggest that a function mediated by two Ir gene products can be blocked by anti-Ia antisera directed against either one, and thus, that both products are expressed on the cell surface.
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UR - http://www.scopus.com/inward/citedby.url?scp=0017891911&partnerID=8YFLogxK
M3 - Article
C2 - 97668
AN - SCOPUS:0017891911
VL - 75
SP - 2387
EP - 2391
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
SN - 0027-8424
IS - 5
ER -