Inhibition of dual Ir gene-controlled T-lymphocyte proliferative response to poly(Glu 56Lys 35Phe 9)(n) with anti-Ia antisera directed against products of either I-A or I-C subregion

R. H. Schwartz, C. S. David, M. E. Dorf, B. Benacerraf, W. E. Paul

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41 Citations (Scopus)

Abstract

Previous studies have demonstrated that both the antibody and T-lymphocyte proliferative immune responses to poly(Glu 53Lys 36Phe 11)(n) (GLΦ) are under the control of two major histocompatibility-linked immune response (Ir) genes. One gene, termed Ir-GLΦ-α, has been mapped to the I-C or I-E subregion of the major histocompatibility complex, while the other, termed Ir-CLΦ-β, has been mapped to the I-A subregion. In this paper we examine the effect of anti-I-region-associated (Ia) antisera on the T-lymphocyte proliferative response to GLΦ. Antibodies directed against Ia antigens coded for by genes in either the I-A or I-C subregion were found to inhibit the proliferative response to GLΦ. These results suggest that a function mediated by two Ir gene products can be blocked by anti-Ia antisera directed against either one, and thus, that both products are expressed on the cell surface.

Original languageEnglish (US)
Pages (from-to)2387-2391
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume75
Issue number5
StatePublished - 1978
Externally publishedYes

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Immune Sera
T-Lymphocytes
Genes
Histocompatibility
Antibodies
Major Histocompatibility Complex
Antigens

ASJC Scopus subject areas

  • Genetics
  • General

Cite this

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title = "Inhibition of dual Ir gene-controlled T-lymphocyte proliferative response to poly(Glu 56Lys 35Phe 9)(n) with anti-Ia antisera directed against products of either I-A or I-C subregion",
abstract = "Previous studies have demonstrated that both the antibody and T-lymphocyte proliferative immune responses to poly(Glu 53Lys 36Phe 11)(n) (GLΦ) are under the control of two major histocompatibility-linked immune response (Ir) genes. One gene, termed Ir-GLΦ-α, has been mapped to the I-C or I-E subregion of the major histocompatibility complex, while the other, termed Ir-CLΦ-β, has been mapped to the I-A subregion. In this paper we examine the effect of anti-I-region-associated (Ia) antisera on the T-lymphocyte proliferative response to GLΦ. Antibodies directed against Ia antigens coded for by genes in either the I-A or I-C subregion were found to inhibit the proliferative response to GLΦ. These results suggest that a function mediated by two Ir gene products can be blocked by anti-Ia antisera directed against either one, and thus, that both products are expressed on the cell surface.",
author = "Schwartz, {R. H.} and David, {C. S.} and Dorf, {M. E.} and B. Benacerraf and Paul, {W. E.}",
year = "1978",
language = "English (US)",
volume = "75",
pages = "2387--2391",
journal = "Proceedings of the National Academy of Sciences of the United States of America",
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TY - JOUR

T1 - Inhibition of dual Ir gene-controlled T-lymphocyte proliferative response to poly(Glu 56Lys 35Phe 9)(n) with anti-Ia antisera directed against products of either I-A or I-C subregion

AU - Schwartz, R. H.

AU - David, C. S.

AU - Dorf, M. E.

AU - Benacerraf, B.

AU - Paul, W. E.

PY - 1978

Y1 - 1978

N2 - Previous studies have demonstrated that both the antibody and T-lymphocyte proliferative immune responses to poly(Glu 53Lys 36Phe 11)(n) (GLΦ) are under the control of two major histocompatibility-linked immune response (Ir) genes. One gene, termed Ir-GLΦ-α, has been mapped to the I-C or I-E subregion of the major histocompatibility complex, while the other, termed Ir-CLΦ-β, has been mapped to the I-A subregion. In this paper we examine the effect of anti-I-region-associated (Ia) antisera on the T-lymphocyte proliferative response to GLΦ. Antibodies directed against Ia antigens coded for by genes in either the I-A or I-C subregion were found to inhibit the proliferative response to GLΦ. These results suggest that a function mediated by two Ir gene products can be blocked by anti-Ia antisera directed against either one, and thus, that both products are expressed on the cell surface.

AB - Previous studies have demonstrated that both the antibody and T-lymphocyte proliferative immune responses to poly(Glu 53Lys 36Phe 11)(n) (GLΦ) are under the control of two major histocompatibility-linked immune response (Ir) genes. One gene, termed Ir-GLΦ-α, has been mapped to the I-C or I-E subregion of the major histocompatibility complex, while the other, termed Ir-CLΦ-β, has been mapped to the I-A subregion. In this paper we examine the effect of anti-I-region-associated (Ia) antisera on the T-lymphocyte proliferative response to GLΦ. Antibodies directed against Ia antigens coded for by genes in either the I-A or I-C subregion were found to inhibit the proliferative response to GLΦ. These results suggest that a function mediated by two Ir gene products can be blocked by anti-Ia antisera directed against either one, and thus, that both products are expressed on the cell surface.

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