Influence of light exposure during early life on the age of onset of bipolar disorder

Michael Bauer, Tasha Glenn, Martin Alda, Ole A. Andreassen, Elias Angelopoulos, Raffaella Ardau, Christopher Baethge, Rita Bauer, Bernhard T. Baune, Frank Bellivier, Robert H. Belmaker, Michael Berk, Thomas D. Bjella, Letizia Bossini, Yuly Bersudsky, Eric Yat Wo Cheung, Jörn Conell, Maria Del Zompo, Seetal Dodd, Bruno EtainAndrea Fagiolini, Mark A Frye, Kostas N. Fountoulakis, Jade Garneau-Fournier, Ana Gonzalez-Pinto, John F. Gottlieb, Hirohiko Harima, Stefanie Hassel, Chantal Henry, Apostolos Iacovides, Erkki T. Isometsä, Flávio Kapczinski, Sebastian Kliwicki, Barbara König, Rikke Krogh, Mauricio Kunz, Beny Lafer, Erik R. Larsen, Ute Lewitzka, Carlos Lopez-Jaramillo, Glenda MacQueen, Mirko Manchia, Wendy Marsh, Mónica Martinez-Cengotitabengoa, Ingrid Melle, Scott Monteith, Gunnar Morken, Rodrigo Munoz, Fabiano G. Nery, Claire O'Donovan, Yamima Osher, Andrea Pfennig, Danilo Quiroz, Raj Ramesar, Natalie Rasgon, Andreas Reif, Philipp Ritter, Janusz K. Rybakowski, Kemal Sagduyu, Ângela Miranda-Scippa, Emanuel Severus, Christian Simhandl, Dan J. Stein, Sergio Strejilevich, Ahmad Hatim Sulaiman, Kirsi Suominen, Hiromi Tagata, Yoshitaka Tatebayashi, Carla Torrent, Eduard Vieta, Biju Viswanath, Mihir J. Wanchoo, Mark Zetin, Peter C. Whybrow

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Background: Environmental conditions early in life may imprint the circadian system and influence response to environmental signals later in life. We previously determined that a large springtime increase in solar insolation at the onset location was associated with a younger age of onset of bipolar disorder, especially with a family history of mood disorders. This study investigated whether the hours of daylight at the birth location affected this association. Methods: Data collected previously at 36 collection sites from 23 countries were available for 3896 patients with bipolar I disorder, born between latitudes of 1.4N and 70.7N, and 1.2S and 41.3S. Hours of daylight variables for the birth location were added to a base model to assess the relation between the age of onset and solar insolation. Results: More hours of daylight at the birth location during early life was associated with an older age of onset, suggesting reduced vulnerability to the future circadian challenge of the springtime increase in solar insolation at the onset location. Addition of the minimum of the average monthly hours of daylight during the first 3 months of life improved the base model, with a significant positive relationship to age of onset. Coefficients for all other variables remained stable, significant and consistent with the base model. Conclusions: Light exposure during early life may have important consequences for those who are susceptible to bipolar disorder, especially at latitudes with little natural light in winter. This study indirectly supports the concept that early life exposure to light may affect the long term adaptability to respond to a circadian challenge later in life.

Original languageEnglish (US)
Pages (from-to)1-8
Number of pages8
JournalJournal of Psychiatric Research
Volume64
DOIs
StatePublished - May 1 2015

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Bipolar Disorder
Age of Onset
Light
Parturition
Onset
Early Life
Mood Disorders

Keywords

  • Age of onset
  • Bipolar disorder
  • Hours of daylight
  • Insolation
  • Sunlight

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry
  • Arts and Humanities (miscellaneous)

Cite this

Bauer, M., Glenn, T., Alda, M., Andreassen, O. A., Angelopoulos, E., Ardau, R., ... Whybrow, P. C. (2015). Influence of light exposure during early life on the age of onset of bipolar disorder. Journal of Psychiatric Research, 64, 1-8. https://doi.org/10.1016/j.jpsychires.2015.03.013

Influence of light exposure during early life on the age of onset of bipolar disorder. / Bauer, Michael; Glenn, Tasha; Alda, Martin; Andreassen, Ole A.; Angelopoulos, Elias; Ardau, Raffaella; Baethge, Christopher; Bauer, Rita; Baune, Bernhard T.; Bellivier, Frank; Belmaker, Robert H.; Berk, Michael; Bjella, Thomas D.; Bossini, Letizia; Bersudsky, Yuly; Wo Cheung, Eric Yat; Conell, Jörn; Del Zompo, Maria; Dodd, Seetal; Etain, Bruno; Fagiolini, Andrea; Frye, Mark A; Fountoulakis, Kostas N.; Garneau-Fournier, Jade; Gonzalez-Pinto, Ana; Gottlieb, John F.; Harima, Hirohiko; Hassel, Stefanie; Henry, Chantal; Iacovides, Apostolos; Isometsä, Erkki T.; Kapczinski, Flávio; Kliwicki, Sebastian; König, Barbara; Krogh, Rikke; Kunz, Mauricio; Lafer, Beny; Larsen, Erik R.; Lewitzka, Ute; Lopez-Jaramillo, Carlos; MacQueen, Glenda; Manchia, Mirko; Marsh, Wendy; Martinez-Cengotitabengoa, Mónica; Melle, Ingrid; Monteith, Scott; Morken, Gunnar; Munoz, Rodrigo; Nery, Fabiano G.; O'Donovan, Claire; Osher, Yamima; Pfennig, Andrea; Quiroz, Danilo; Ramesar, Raj; Rasgon, Natalie; Reif, Andreas; Ritter, Philipp; Rybakowski, Janusz K.; Sagduyu, Kemal; Miranda-Scippa, Ângela; Severus, Emanuel; Simhandl, Christian; Stein, Dan J.; Strejilevich, Sergio; Sulaiman, Ahmad Hatim; Suominen, Kirsi; Tagata, Hiromi; Tatebayashi, Yoshitaka; Torrent, Carla; Vieta, Eduard; Viswanath, Biju; Wanchoo, Mihir J.; Zetin, Mark; Whybrow, Peter C.

In: Journal of Psychiatric Research, Vol. 64, 01.05.2015, p. 1-8.

Research output: Contribution to journalArticle

Bauer, M, Glenn, T, Alda, M, Andreassen, OA, Angelopoulos, E, Ardau, R, Baethge, C, Bauer, R, Baune, BT, Bellivier, F, Belmaker, RH, Berk, M, Bjella, TD, Bossini, L, Bersudsky, Y, Wo Cheung, EY, Conell, J, Del Zompo, M, Dodd, S, Etain, B, Fagiolini, A, Frye, MA, Fountoulakis, KN, Garneau-Fournier, J, Gonzalez-Pinto, A, Gottlieb, JF, Harima, H, Hassel, S, Henry, C, Iacovides, A, Isometsä, ET, Kapczinski, F, Kliwicki, S, König, B, Krogh, R, Kunz, M, Lafer, B, Larsen, ER, Lewitzka, U, Lopez-Jaramillo, C, MacQueen, G, Manchia, M, Marsh, W, Martinez-Cengotitabengoa, M, Melle, I, Monteith, S, Morken, G, Munoz, R, Nery, FG, O'Donovan, C, Osher, Y, Pfennig, A, Quiroz, D, Ramesar, R, Rasgon, N, Reif, A, Ritter, P, Rybakowski, JK, Sagduyu, K, Miranda-Scippa, Â, Severus, E, Simhandl, C, Stein, DJ, Strejilevich, S, Sulaiman, AH, Suominen, K, Tagata, H, Tatebayashi, Y, Torrent, C, Vieta, E, Viswanath, B, Wanchoo, MJ, Zetin, M & Whybrow, PC 2015, 'Influence of light exposure during early life on the age of onset of bipolar disorder', Journal of Psychiatric Research, vol. 64, pp. 1-8. https://doi.org/10.1016/j.jpsychires.2015.03.013
Bauer, Michael ; Glenn, Tasha ; Alda, Martin ; Andreassen, Ole A. ; Angelopoulos, Elias ; Ardau, Raffaella ; Baethge, Christopher ; Bauer, Rita ; Baune, Bernhard T. ; Bellivier, Frank ; Belmaker, Robert H. ; Berk, Michael ; Bjella, Thomas D. ; Bossini, Letizia ; Bersudsky, Yuly ; Wo Cheung, Eric Yat ; Conell, Jörn ; Del Zompo, Maria ; Dodd, Seetal ; Etain, Bruno ; Fagiolini, Andrea ; Frye, Mark A ; Fountoulakis, Kostas N. ; Garneau-Fournier, Jade ; Gonzalez-Pinto, Ana ; Gottlieb, John F. ; Harima, Hirohiko ; Hassel, Stefanie ; Henry, Chantal ; Iacovides, Apostolos ; Isometsä, Erkki T. ; Kapczinski, Flávio ; Kliwicki, Sebastian ; König, Barbara ; Krogh, Rikke ; Kunz, Mauricio ; Lafer, Beny ; Larsen, Erik R. ; Lewitzka, Ute ; Lopez-Jaramillo, Carlos ; MacQueen, Glenda ; Manchia, Mirko ; Marsh, Wendy ; Martinez-Cengotitabengoa, Mónica ; Melle, Ingrid ; Monteith, Scott ; Morken, Gunnar ; Munoz, Rodrigo ; Nery, Fabiano G. ; O'Donovan, Claire ; Osher, Yamima ; Pfennig, Andrea ; Quiroz, Danilo ; Ramesar, Raj ; Rasgon, Natalie ; Reif, Andreas ; Ritter, Philipp ; Rybakowski, Janusz K. ; Sagduyu, Kemal ; Miranda-Scippa, Ângela ; Severus, Emanuel ; Simhandl, Christian ; Stein, Dan J. ; Strejilevich, Sergio ; Sulaiman, Ahmad Hatim ; Suominen, Kirsi ; Tagata, Hiromi ; Tatebayashi, Yoshitaka ; Torrent, Carla ; Vieta, Eduard ; Viswanath, Biju ; Wanchoo, Mihir J. ; Zetin, Mark ; Whybrow, Peter C. / Influence of light exposure during early life on the age of onset of bipolar disorder. In: Journal of Psychiatric Research. 2015 ; Vol. 64. pp. 1-8.
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abstract = "Background: Environmental conditions early in life may imprint the circadian system and influence response to environmental signals later in life. We previously determined that a large springtime increase in solar insolation at the onset location was associated with a younger age of onset of bipolar disorder, especially with a family history of mood disorders. This study investigated whether the hours of daylight at the birth location affected this association. Methods: Data collected previously at 36 collection sites from 23 countries were available for 3896 patients with bipolar I disorder, born between latitudes of 1.4N and 70.7N, and 1.2S and 41.3S. Hours of daylight variables for the birth location were added to a base model to assess the relation between the age of onset and solar insolation. Results: More hours of daylight at the birth location during early life was associated with an older age of onset, suggesting reduced vulnerability to the future circadian challenge of the springtime increase in solar insolation at the onset location. Addition of the minimum of the average monthly hours of daylight during the first 3 months of life improved the base model, with a significant positive relationship to age of onset. Coefficients for all other variables remained stable, significant and consistent with the base model. Conclusions: Light exposure during early life may have important consequences for those who are susceptible to bipolar disorder, especially at latitudes with little natural light in winter. This study indirectly supports the concept that early life exposure to light may affect the long term adaptability to respond to a circadian challenge later in life.",
keywords = "Age of onset, Bipolar disorder, Hours of daylight, Insolation, Sunlight",
author = "Michael Bauer and Tasha Glenn and Martin Alda and Andreassen, {Ole A.} and Elias Angelopoulos and Raffaella Ardau and Christopher Baethge and Rita Bauer and Baune, {Bernhard T.} and Frank Bellivier and Belmaker, {Robert H.} and Michael Berk and Bjella, {Thomas D.} and Letizia Bossini and Yuly Bersudsky and {Wo Cheung}, {Eric Yat} and J{\"o}rn Conell and {Del Zompo}, Maria and Seetal Dodd and Bruno Etain and Andrea Fagiolini and Frye, {Mark A} and Fountoulakis, {Kostas N.} and Jade Garneau-Fournier and Ana Gonzalez-Pinto and Gottlieb, {John F.} and Hirohiko Harima and Stefanie Hassel and Chantal Henry and Apostolos Iacovides and Isomets{\"a}, {Erkki T.} and Fl{\'a}vio Kapczinski and Sebastian Kliwicki and Barbara K{\"o}nig and Rikke Krogh and Mauricio Kunz and Beny Lafer and Larsen, {Erik R.} and Ute Lewitzka and Carlos Lopez-Jaramillo and Glenda MacQueen and Mirko Manchia and Wendy Marsh and M{\'o}nica Martinez-Cengotitabengoa and Ingrid Melle and Scott Monteith and Gunnar Morken and Rodrigo Munoz and Nery, {Fabiano G.} and Claire O'Donovan and Yamima Osher and Andrea Pfennig and Danilo Quiroz and Raj Ramesar and Natalie Rasgon and Andreas Reif and Philipp Ritter and Rybakowski, {Janusz K.} and Kemal Sagduyu and {\^A}ngela Miranda-Scippa and Emanuel Severus and Christian Simhandl and Stein, {Dan J.} and Sergio Strejilevich and Sulaiman, {Ahmad Hatim} and Kirsi Suominen and Hiromi Tagata and Yoshitaka Tatebayashi and Carla Torrent and Eduard Vieta and Biju Viswanath and Wanchoo, {Mihir J.} and Mark Zetin and Whybrow, {Peter C.}",
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T1 - Influence of light exposure during early life on the age of onset of bipolar disorder

AU - Bauer, Michael

AU - Glenn, Tasha

AU - Alda, Martin

AU - Andreassen, Ole A.

AU - Angelopoulos, Elias

AU - Ardau, Raffaella

AU - Baethge, Christopher

AU - Bauer, Rita

AU - Baune, Bernhard T.

AU - Bellivier, Frank

AU - Belmaker, Robert H.

AU - Berk, Michael

AU - Bjella, Thomas D.

AU - Bossini, Letizia

AU - Bersudsky, Yuly

AU - Wo Cheung, Eric Yat

AU - Conell, Jörn

AU - Del Zompo, Maria

AU - Dodd, Seetal

AU - Etain, Bruno

AU - Fagiolini, Andrea

AU - Frye, Mark A

AU - Fountoulakis, Kostas N.

AU - Garneau-Fournier, Jade

AU - Gonzalez-Pinto, Ana

AU - Gottlieb, John F.

AU - Harima, Hirohiko

AU - Hassel, Stefanie

AU - Henry, Chantal

AU - Iacovides, Apostolos

AU - Isometsä, Erkki T.

AU - Kapczinski, Flávio

AU - Kliwicki, Sebastian

AU - König, Barbara

AU - Krogh, Rikke

AU - Kunz, Mauricio

AU - Lafer, Beny

AU - Larsen, Erik R.

AU - Lewitzka, Ute

AU - Lopez-Jaramillo, Carlos

AU - MacQueen, Glenda

AU - Manchia, Mirko

AU - Marsh, Wendy

AU - Martinez-Cengotitabengoa, Mónica

AU - Melle, Ingrid

AU - Monteith, Scott

AU - Morken, Gunnar

AU - Munoz, Rodrigo

AU - Nery, Fabiano G.

AU - O'Donovan, Claire

AU - Osher, Yamima

AU - Pfennig, Andrea

AU - Quiroz, Danilo

AU - Ramesar, Raj

AU - Rasgon, Natalie

AU - Reif, Andreas

AU - Ritter, Philipp

AU - Rybakowski, Janusz K.

AU - Sagduyu, Kemal

AU - Miranda-Scippa, Ângela

AU - Severus, Emanuel

AU - Simhandl, Christian

AU - Stein, Dan J.

AU - Strejilevich, Sergio

AU - Sulaiman, Ahmad Hatim

AU - Suominen, Kirsi

AU - Tagata, Hiromi

AU - Tatebayashi, Yoshitaka

AU - Torrent, Carla

AU - Vieta, Eduard

AU - Viswanath, Biju

AU - Wanchoo, Mihir J.

AU - Zetin, Mark

AU - Whybrow, Peter C.

PY - 2015/5/1

Y1 - 2015/5/1

N2 - Background: Environmental conditions early in life may imprint the circadian system and influence response to environmental signals later in life. We previously determined that a large springtime increase in solar insolation at the onset location was associated with a younger age of onset of bipolar disorder, especially with a family history of mood disorders. This study investigated whether the hours of daylight at the birth location affected this association. Methods: Data collected previously at 36 collection sites from 23 countries were available for 3896 patients with bipolar I disorder, born between latitudes of 1.4N and 70.7N, and 1.2S and 41.3S. Hours of daylight variables for the birth location were added to a base model to assess the relation between the age of onset and solar insolation. Results: More hours of daylight at the birth location during early life was associated with an older age of onset, suggesting reduced vulnerability to the future circadian challenge of the springtime increase in solar insolation at the onset location. Addition of the minimum of the average monthly hours of daylight during the first 3 months of life improved the base model, with a significant positive relationship to age of onset. Coefficients for all other variables remained stable, significant and consistent with the base model. Conclusions: Light exposure during early life may have important consequences for those who are susceptible to bipolar disorder, especially at latitudes with little natural light in winter. This study indirectly supports the concept that early life exposure to light may affect the long term adaptability to respond to a circadian challenge later in life.

AB - Background: Environmental conditions early in life may imprint the circadian system and influence response to environmental signals later in life. We previously determined that a large springtime increase in solar insolation at the onset location was associated with a younger age of onset of bipolar disorder, especially with a family history of mood disorders. This study investigated whether the hours of daylight at the birth location affected this association. Methods: Data collected previously at 36 collection sites from 23 countries were available for 3896 patients with bipolar I disorder, born between latitudes of 1.4N and 70.7N, and 1.2S and 41.3S. Hours of daylight variables for the birth location were added to a base model to assess the relation between the age of onset and solar insolation. Results: More hours of daylight at the birth location during early life was associated with an older age of onset, suggesting reduced vulnerability to the future circadian challenge of the springtime increase in solar insolation at the onset location. Addition of the minimum of the average monthly hours of daylight during the first 3 months of life improved the base model, with a significant positive relationship to age of onset. Coefficients for all other variables remained stable, significant and consistent with the base model. Conclusions: Light exposure during early life may have important consequences for those who are susceptible to bipolar disorder, especially at latitudes with little natural light in winter. This study indirectly supports the concept that early life exposure to light may affect the long term adaptability to respond to a circadian challenge later in life.

KW - Age of onset

KW - Bipolar disorder

KW - Hours of daylight

KW - Insolation

KW - Sunlight

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