Influence of body fatness distribution and total lean mass on aortic stiffness in nonobese individuals

Peter Wohlfahrt, Virend Somers, Ondrej Sochor, Iftikhar Jan Kullo, Nathalie Jean, Francisco Lopez-Jimenez

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

BACKGROUND: Subjects with normal body mass index but high body fat percentage have higher cardiovascular risk than subjects with normal weight and low fat mass. However, the association of fat distribution and lean mass with carotid-femoral pulse wave velocity (cfPWV) among nonobese apparently healthy individuals has never been assessed.

METHODS: In 136 nonobese volunteers (mean age = 45±9 years; 57% women) without manifest cardiovascular disease, cfPWV was measured by applanation tonometry. Fat and lean mass were measured by dual-energy x-ray absorptiometry.

RESULTS: In univariate analysis, total fat (r = 0.17; P <0.01), trunk fat (r = 0.27; P <0.01), and trunk/total fat ratio (r = 0.32; P <0.01) were correlated with cfPWV. After adjustment for age and mean arterial pressure, only central fat distribution (trunk/total fat ratio) was significantly associated with cfPWV. In the fully adjustment model, there was a significant interaction between fat distribution and lean mass. When the study sample was grouped by fat distribution and total lean mass medians, subjects with central fat distribution and low lean mass (group 4) had higher log-transformed cfPWV than the noncentral fat/low lean mass group (group 2) (0.89, 95% confidence interval (CI) = 0.86-0.92 vs. 0.85, 95% CI = 0.83-0.87; P <0.01) or the noncentral fat/high lean mass group (group 1) (0.89, 95% CI = 0.86-0.92 vs. 0.84, 95% CI = 0.81-0.87; P <0.01) after adjustments. Aortic stiffness increased from group 1 to group 4 (P for linear trend <0.001).

CONCLUSIONS: Among normal weight individuals without manifest cardiovascular disease, the combination of central fat distribution and low lean mass is associated with higher cfPWV. These factors are more closely related to cfPWV than total fat mass.

Original languageEnglish (US)
Pages (from-to)401-408
Number of pages8
JournalAmerican Journal of Hypertension
Volume28
Issue number3
DOIs
StatePublished - Mar 1 2015

Fingerprint

Vascular Stiffness
Fats
Pulse Wave Analysis
Thigh
Confidence Intervals
Cardiovascular Diseases
Weights and Measures
Manometry

Keywords

  • adiponectin
  • arterial stiffness
  • blood pressure
  • central obesity
  • DEXA
  • hypertension
  • lean mass
  • normal weight obesity
  • pulse wave velocity.

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Influence of body fatness distribution and total lean mass on aortic stiffness in nonobese individuals. / Wohlfahrt, Peter; Somers, Virend; Sochor, Ondrej; Kullo, Iftikhar Jan; Jean, Nathalie; Lopez-Jimenez, Francisco.

In: American Journal of Hypertension, Vol. 28, No. 3, 01.03.2015, p. 401-408.

Research output: Contribution to journalArticle

@article{4102f932b30247aa9c77066262673b5d,
title = "Influence of body fatness distribution and total lean mass on aortic stiffness in nonobese individuals",
abstract = "BACKGROUND: Subjects with normal body mass index but high body fat percentage have higher cardiovascular risk than subjects with normal weight and low fat mass. However, the association of fat distribution and lean mass with carotid-femoral pulse wave velocity (cfPWV) among nonobese apparently healthy individuals has never been assessed.METHODS: In 136 nonobese volunteers (mean age = 45±9 years; 57{\%} women) without manifest cardiovascular disease, cfPWV was measured by applanation tonometry. Fat and lean mass were measured by dual-energy x-ray absorptiometry.RESULTS: In univariate analysis, total fat (r = 0.17; P <0.01), trunk fat (r = 0.27; P <0.01), and trunk/total fat ratio (r = 0.32; P <0.01) were correlated with cfPWV. After adjustment for age and mean arterial pressure, only central fat distribution (trunk/total fat ratio) was significantly associated with cfPWV. In the fully adjustment model, there was a significant interaction between fat distribution and lean mass. When the study sample was grouped by fat distribution and total lean mass medians, subjects with central fat distribution and low lean mass (group 4) had higher log-transformed cfPWV than the noncentral fat/low lean mass group (group 2) (0.89, 95{\%} confidence interval (CI) = 0.86-0.92 vs. 0.85, 95{\%} CI = 0.83-0.87; P <0.01) or the noncentral fat/high lean mass group (group 1) (0.89, 95{\%} CI = 0.86-0.92 vs. 0.84, 95{\%} CI = 0.81-0.87; P <0.01) after adjustments. Aortic stiffness increased from group 1 to group 4 (P for linear trend <0.001).CONCLUSIONS: Among normal weight individuals without manifest cardiovascular disease, the combination of central fat distribution and low lean mass is associated with higher cfPWV. These factors are more closely related to cfPWV than total fat mass.",
keywords = "adiponectin, arterial stiffness, blood pressure, central obesity, DEXA, hypertension, lean mass, normal weight obesity, pulse wave velocity.",
author = "Peter Wohlfahrt and Virend Somers and Ondrej Sochor and Kullo, {Iftikhar Jan} and Nathalie Jean and Francisco Lopez-Jimenez",
year = "2015",
month = "3",
day = "1",
doi = "10.1093/ajh/hpu153",
language = "English (US)",
volume = "28",
pages = "401--408",
journal = "American Journal of Hypertension",
issn = "0895-7061",
publisher = "Oxford University Press",
number = "3",

}

TY - JOUR

T1 - Influence of body fatness distribution and total lean mass on aortic stiffness in nonobese individuals

AU - Wohlfahrt, Peter

AU - Somers, Virend

AU - Sochor, Ondrej

AU - Kullo, Iftikhar Jan

AU - Jean, Nathalie

AU - Lopez-Jimenez, Francisco

PY - 2015/3/1

Y1 - 2015/3/1

N2 - BACKGROUND: Subjects with normal body mass index but high body fat percentage have higher cardiovascular risk than subjects with normal weight and low fat mass. However, the association of fat distribution and lean mass with carotid-femoral pulse wave velocity (cfPWV) among nonobese apparently healthy individuals has never been assessed.METHODS: In 136 nonobese volunteers (mean age = 45±9 years; 57% women) without manifest cardiovascular disease, cfPWV was measured by applanation tonometry. Fat and lean mass were measured by dual-energy x-ray absorptiometry.RESULTS: In univariate analysis, total fat (r = 0.17; P <0.01), trunk fat (r = 0.27; P <0.01), and trunk/total fat ratio (r = 0.32; P <0.01) were correlated with cfPWV. After adjustment for age and mean arterial pressure, only central fat distribution (trunk/total fat ratio) was significantly associated with cfPWV. In the fully adjustment model, there was a significant interaction between fat distribution and lean mass. When the study sample was grouped by fat distribution and total lean mass medians, subjects with central fat distribution and low lean mass (group 4) had higher log-transformed cfPWV than the noncentral fat/low lean mass group (group 2) (0.89, 95% confidence interval (CI) = 0.86-0.92 vs. 0.85, 95% CI = 0.83-0.87; P <0.01) or the noncentral fat/high lean mass group (group 1) (0.89, 95% CI = 0.86-0.92 vs. 0.84, 95% CI = 0.81-0.87; P <0.01) after adjustments. Aortic stiffness increased from group 1 to group 4 (P for linear trend <0.001).CONCLUSIONS: Among normal weight individuals without manifest cardiovascular disease, the combination of central fat distribution and low lean mass is associated with higher cfPWV. These factors are more closely related to cfPWV than total fat mass.

AB - BACKGROUND: Subjects with normal body mass index but high body fat percentage have higher cardiovascular risk than subjects with normal weight and low fat mass. However, the association of fat distribution and lean mass with carotid-femoral pulse wave velocity (cfPWV) among nonobese apparently healthy individuals has never been assessed.METHODS: In 136 nonobese volunteers (mean age = 45±9 years; 57% women) without manifest cardiovascular disease, cfPWV was measured by applanation tonometry. Fat and lean mass were measured by dual-energy x-ray absorptiometry.RESULTS: In univariate analysis, total fat (r = 0.17; P <0.01), trunk fat (r = 0.27; P <0.01), and trunk/total fat ratio (r = 0.32; P <0.01) were correlated with cfPWV. After adjustment for age and mean arterial pressure, only central fat distribution (trunk/total fat ratio) was significantly associated with cfPWV. In the fully adjustment model, there was a significant interaction between fat distribution and lean mass. When the study sample was grouped by fat distribution and total lean mass medians, subjects with central fat distribution and low lean mass (group 4) had higher log-transformed cfPWV than the noncentral fat/low lean mass group (group 2) (0.89, 95% confidence interval (CI) = 0.86-0.92 vs. 0.85, 95% CI = 0.83-0.87; P <0.01) or the noncentral fat/high lean mass group (group 1) (0.89, 95% CI = 0.86-0.92 vs. 0.84, 95% CI = 0.81-0.87; P <0.01) after adjustments. Aortic stiffness increased from group 1 to group 4 (P for linear trend <0.001).CONCLUSIONS: Among normal weight individuals without manifest cardiovascular disease, the combination of central fat distribution and low lean mass is associated with higher cfPWV. These factors are more closely related to cfPWV than total fat mass.

KW - adiponectin

KW - arterial stiffness

KW - blood pressure

KW - central obesity

KW - DEXA

KW - hypertension

KW - lean mass

KW - normal weight obesity

KW - pulse wave velocity.

UR - http://www.scopus.com/inward/record.url?scp=84927590311&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84927590311&partnerID=8YFLogxK

U2 - 10.1093/ajh/hpu153

DO - 10.1093/ajh/hpu153

M3 - Article

C2 - 25189869

AN - SCOPUS:84927590311

VL - 28

SP - 401

EP - 408

JO - American Journal of Hypertension

JF - American Journal of Hypertension

SN - 0895-7061

IS - 3

ER -