Inflammatory myofibroblastic tumor involving the central nervous system

W. Robert Bell, Ignacio Jusué-Torres, Alfredo Quiñones-Hinojosa, Fausto J. Rodriguez

Research output: Contribution to journalArticle

Abstract

Inflammatory myofibroblastic tumor (IMT) is a distinct mesenchymal neoplasm that arises in the lung, soft tissues and a variety of organs. In the past, morphologic and conceptual overlap with inflammatory pseudotumor, a presumed inflammatory lesion, has been described in the literature. However, demonstration of ALK gene rearrangements in a subset of cases supports the concept of a distinct neoplastic entity. In rare instances, it may involve the central nervous system, and present as a dural based mass mimicking meningioma. IMT has variable clinical behavior but may also behave in a malignant fashion in a proportion of cases. Interestingly, multicentricity has also been described with IMT. We discuss the case of a 30-year old woman who developed a well circumscribed intracranial mass interpreted preoperatively as a meningioma. Histologic examination demonstrated IMT containing an ALK rearrangement. The neoplasm was morphologically similar to a lung neoplasm resected 31 months previously. We use this case study as an opportunity to discuss the differential diagnosis of IMT with a focus on intrancranial locations and useful ancillary techniques in approaching the pathologic diagnosis.

Original languageEnglish (US)
Pages (from-to)257-261
Number of pages5
JournalPathology Case Reviews
Volume18
Issue number6
DOIs
StatePublished - Dec 1 2013

Keywords

  • ALK
  • Inflammatory myofibroblastic tumor
  • Inflammatory pseudotumor
  • Meningioma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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