Inflammatory changes in the central nervous system are associated with behavioral impairment in Plasmodium berghei (strain ANKA)-infected mice

Norinne Lacerda-Queiroz, David Henrique Rodrigues, Márcia Carvalho Vilela, Aline Silva de Miranda, Débora Cristina Guerra Amaral, Elizabeth Ribeiro da Silva Camargos, Leonardo José de Moura Carvalho, Charles L. Howe, Mauro Martins Teixeira, Antônio Lúcio Teixeira

Research output: Contribution to journalArticle

33 Scopus citations

Abstract

Experimental cerebral malaria is a neuroinflammatory condition that results from the host immune response to the parasite. Using intravital microscopy, we investigated leukocyte recruitment in the brain microcirculation and the temporal relationship of this process to the behavioral changes observed in Plasmodium berghei (strain ANKA)-infected C57Bl/6 mice. We found that leukocyte recruitment was increased from day 5 post-infection (p.i.) onwards. Histopathological changes and increased levels of inflammatory cytokines in the brain were also observed. Behavioral performance evaluated by the SHIRPA protocol showed functional impairment from day 6 p.i. onwards. Thus, early leukocyte migration into the brain and associated inflammatory changes may be involved in neurological impairment in parasite-infected C57Bl/6 mice.

Original languageEnglish (US)
Pages (from-to)271-278
Number of pages8
JournalExperimental Parasitology
Volume125
Issue number3
DOIs
StatePublished - Jul 2010

Keywords

  • Behavior
  • Cerebral malaria
  • Cytokines
  • Intravital microscopy
  • Leukocyte recruitment

ASJC Scopus subject areas

  • Parasitology
  • Immunology
  • Infectious Diseases

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    Lacerda-Queiroz, N., Rodrigues, D. H., Vilela, M. C., Miranda, A. S. D., Amaral, D. C. G., Camargos, E. R. D. S., Carvalho, L. J. D. M., Howe, C. L., Teixeira, M. M., & Teixeira, A. L. (2010). Inflammatory changes in the central nervous system are associated with behavioral impairment in Plasmodium berghei (strain ANKA)-infected mice. Experimental Parasitology, 125(3), 271-278. https://doi.org/10.1016/j.exppara.2010.02.002