Inflammatory and nutritional serum markers as predictors of peri-operative morbidity and survival in ovarian cancer

Amanika Kumar, Michelle L. Torres, William Arthur Cliby, Kimberly R. Kalli, Giorgio Bogani, Giovanni Aletti, Caroline C. Nitschmann, Francesco Multinu, Amy L. Weaver, Matthew S Block, Andrea Mariani

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Aim: To identify preoperative nutritional and inflammatory markers that predict perioperative outcomes in patients with ovarian cancer (OC). Patients and Methods: Fifty patients who underwent primary debulking for advanced (stage III/IV) OC were selected from a cohort of patients who underwent surgery between 2002 and 2009. We analyzed C-reactive protein (CRP), interleukin-6 (IL6) and albumin and their impact on mortality and surgical outcomeS. Results: Two patients were excluded since they did not have adequate measurements of CRP and IL6. Among the remaining patients, 25 (52%) were 70 years old. Nine (19%), 12 (25%) and 12 (25%) patients had low serum albumin (<3.0 g/dl), elevated CRP (70 mg/l) and elevated IL6 (24 pg/ml), respectively. Age was a significant predictor of non-home discharge (p=0.01). Low serum albumin (<3.0 g/dl) was a predictor of death within 6 month (p=0.03). Elevated CRP (70 mg/l) was a predictor of nonhome discharge (p=0.02), death within 6 months (p=0.02), death within 12 months (p=0.04), and longer hospital stay (p=0.01). Elevated IL6 (24 pg/ml) was a predictor of nonhome discharge (p=0.002) and surgical complications (p=0.02), and also associated with longer hospital stay (p=0.03). Conclusion: Poor nutrition and high inflammatory status negatively influence surgical and oncological outcomes of patients with OC. These preoperative markers can be used for selection of patients for neoadjuvant chemotherapy at high risk of short survival, non-home discharge and long hospital stay.

Original languageEnglish (US)
Pages (from-to)3673-3677
Number of pages5
JournalAnticancer Research
Volume37
Issue number7
DOIs
StatePublished - Jul 1 2017

Fingerprint

Ovarian Neoplasms
Biomarkers
Morbidity
Survival
C-Reactive Protein
Interleukin-6
Length of Stay
Serum Albumin
Patient Selection
Albumins
Drug Therapy
Mortality

Keywords

  • Albumin
  • CRP
  • Frailty
  • IL6
  • Malnutrition
  • Ovarian cancer

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Inflammatory and nutritional serum markers as predictors of peri-operative morbidity and survival in ovarian cancer. / Kumar, Amanika; Torres, Michelle L.; Cliby, William Arthur; Kalli, Kimberly R.; Bogani, Giorgio; Aletti, Giovanni; Nitschmann, Caroline C.; Multinu, Francesco; Weaver, Amy L.; Block, Matthew S; Mariani, Andrea.

In: Anticancer Research, Vol. 37, No. 7, 01.07.2017, p. 3673-3677.

Research output: Contribution to journalArticle

Kumar, A, Torres, ML, Cliby, WA, Kalli, KR, Bogani, G, Aletti, G, Nitschmann, CC, Multinu, F, Weaver, AL, Block, MS & Mariani, A 2017, 'Inflammatory and nutritional serum markers as predictors of peri-operative morbidity and survival in ovarian cancer', Anticancer Research, vol. 37, no. 7, pp. 3673-3677. https://doi.org/10.21873/anticanreS.11738
Kumar, Amanika ; Torres, Michelle L. ; Cliby, William Arthur ; Kalli, Kimberly R. ; Bogani, Giorgio ; Aletti, Giovanni ; Nitschmann, Caroline C. ; Multinu, Francesco ; Weaver, Amy L. ; Block, Matthew S ; Mariani, Andrea. / Inflammatory and nutritional serum markers as predictors of peri-operative morbidity and survival in ovarian cancer. In: Anticancer Research. 2017 ; Vol. 37, No. 7. pp. 3673-3677.
@article{2978dfb33abf4b57a44bb28df8f71bfb,
title = "Inflammatory and nutritional serum markers as predictors of peri-operative morbidity and survival in ovarian cancer",
abstract = "Aim: To identify preoperative nutritional and inflammatory markers that predict perioperative outcomes in patients with ovarian cancer (OC). Patients and Methods: Fifty patients who underwent primary debulking for advanced (stage III/IV) OC were selected from a cohort of patients who underwent surgery between 2002 and 2009. We analyzed C-reactive protein (CRP), interleukin-6 (IL6) and albumin and their impact on mortality and surgical outcomeS. Results: Two patients were excluded since they did not have adequate measurements of CRP and IL6. Among the remaining patients, 25 (52{\%}) were 70 years old. Nine (19{\%}), 12 (25{\%}) and 12 (25{\%}) patients had low serum albumin (<3.0 g/dl), elevated CRP (70 mg/l) and elevated IL6 (24 pg/ml), respectively. Age was a significant predictor of non-home discharge (p=0.01). Low serum albumin (<3.0 g/dl) was a predictor of death within 6 month (p=0.03). Elevated CRP (70 mg/l) was a predictor of nonhome discharge (p=0.02), death within 6 months (p=0.02), death within 12 months (p=0.04), and longer hospital stay (p=0.01). Elevated IL6 (24 pg/ml) was a predictor of nonhome discharge (p=0.002) and surgical complications (p=0.02), and also associated with longer hospital stay (p=0.03). Conclusion: Poor nutrition and high inflammatory status negatively influence surgical and oncological outcomes of patients with OC. These preoperative markers can be used for selection of patients for neoadjuvant chemotherapy at high risk of short survival, non-home discharge and long hospital stay.",
keywords = "Albumin, CRP, Frailty, IL6, Malnutrition, Ovarian cancer",
author = "Amanika Kumar and Torres, {Michelle L.} and Cliby, {William Arthur} and Kalli, {Kimberly R.} and Giorgio Bogani and Giovanni Aletti and Nitschmann, {Caroline C.} and Francesco Multinu and Weaver, {Amy L.} and Block, {Matthew S} and Andrea Mariani",
year = "2017",
month = "7",
day = "1",
doi = "10.21873/anticanreS.11738",
language = "English (US)",
volume = "37",
pages = "3673--3677",
journal = "Anticancer Research",
issn = "0250-7005",
publisher = "International Institute of Anticancer Research",
number = "7",

}

TY - JOUR

T1 - Inflammatory and nutritional serum markers as predictors of peri-operative morbidity and survival in ovarian cancer

AU - Kumar, Amanika

AU - Torres, Michelle L.

AU - Cliby, William Arthur

AU - Kalli, Kimberly R.

AU - Bogani, Giorgio

AU - Aletti, Giovanni

AU - Nitschmann, Caroline C.

AU - Multinu, Francesco

AU - Weaver, Amy L.

AU - Block, Matthew S

AU - Mariani, Andrea

PY - 2017/7/1

Y1 - 2017/7/1

N2 - Aim: To identify preoperative nutritional and inflammatory markers that predict perioperative outcomes in patients with ovarian cancer (OC). Patients and Methods: Fifty patients who underwent primary debulking for advanced (stage III/IV) OC were selected from a cohort of patients who underwent surgery between 2002 and 2009. We analyzed C-reactive protein (CRP), interleukin-6 (IL6) and albumin and their impact on mortality and surgical outcomeS. Results: Two patients were excluded since they did not have adequate measurements of CRP and IL6. Among the remaining patients, 25 (52%) were 70 years old. Nine (19%), 12 (25%) and 12 (25%) patients had low serum albumin (<3.0 g/dl), elevated CRP (70 mg/l) and elevated IL6 (24 pg/ml), respectively. Age was a significant predictor of non-home discharge (p=0.01). Low serum albumin (<3.0 g/dl) was a predictor of death within 6 month (p=0.03). Elevated CRP (70 mg/l) was a predictor of nonhome discharge (p=0.02), death within 6 months (p=0.02), death within 12 months (p=0.04), and longer hospital stay (p=0.01). Elevated IL6 (24 pg/ml) was a predictor of nonhome discharge (p=0.002) and surgical complications (p=0.02), and also associated with longer hospital stay (p=0.03). Conclusion: Poor nutrition and high inflammatory status negatively influence surgical and oncological outcomes of patients with OC. These preoperative markers can be used for selection of patients for neoadjuvant chemotherapy at high risk of short survival, non-home discharge and long hospital stay.

AB - Aim: To identify preoperative nutritional and inflammatory markers that predict perioperative outcomes in patients with ovarian cancer (OC). Patients and Methods: Fifty patients who underwent primary debulking for advanced (stage III/IV) OC were selected from a cohort of patients who underwent surgery between 2002 and 2009. We analyzed C-reactive protein (CRP), interleukin-6 (IL6) and albumin and their impact on mortality and surgical outcomeS. Results: Two patients were excluded since they did not have adequate measurements of CRP and IL6. Among the remaining patients, 25 (52%) were 70 years old. Nine (19%), 12 (25%) and 12 (25%) patients had low serum albumin (<3.0 g/dl), elevated CRP (70 mg/l) and elevated IL6 (24 pg/ml), respectively. Age was a significant predictor of non-home discharge (p=0.01). Low serum albumin (<3.0 g/dl) was a predictor of death within 6 month (p=0.03). Elevated CRP (70 mg/l) was a predictor of nonhome discharge (p=0.02), death within 6 months (p=0.02), death within 12 months (p=0.04), and longer hospital stay (p=0.01). Elevated IL6 (24 pg/ml) was a predictor of nonhome discharge (p=0.002) and surgical complications (p=0.02), and also associated with longer hospital stay (p=0.03). Conclusion: Poor nutrition and high inflammatory status negatively influence surgical and oncological outcomes of patients with OC. These preoperative markers can be used for selection of patients for neoadjuvant chemotherapy at high risk of short survival, non-home discharge and long hospital stay.

KW - Albumin

KW - CRP

KW - Frailty

KW - IL6

KW - Malnutrition

KW - Ovarian cancer

UR - http://www.scopus.com/inward/record.url?scp=85021832525&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85021832525&partnerID=8YFLogxK

U2 - 10.21873/anticanreS.11738

DO - 10.21873/anticanreS.11738

M3 - Article

VL - 37

SP - 3673

EP - 3677

JO - Anticancer Research

JF - Anticancer Research

SN - 0250-7005

IS - 7

ER -