Infections in transplant recipients

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Introduction Infections are the most common complication of organ and tissue transplantation. While the focus of antimicrobial prevention after transplantation has been on reducing the incidence of opportunistic infections, transplant recipients remain at risk of virtually any bacterial, fungal, viral, and parasitic pathogen. These pathogens cause clinical disease with increased severity in a transplant recipient. Several factors inherent to the transplant recipient or related to the donor, the environment, and the circumstances surrounding the transplant procedure (such as surgical techniques and immunosuppressive drugs) increase the risk of infectious complications. Generally, the overall infection risk after transplantation is determined by (1) epidemiologic exposures of the donor and the recipient and (2) the overall net state of immunosuppression. Epidemiologic exposures The major sources of pathogens are (1) the transplant recipient who may harbor latent, active, or subclinical infection prior to transplantation; (2) the donor who may harbor latent, active, or subclinical infection that could be transmitted through the allograft (donor-derived infections); and (3) the environment (hospital and community). Table 89.1 lists some risk factors for acquiring infection after solid organ transplantation. THE TRANSPLANT RECIPIENT The epidemiologic exposures of potential transplant recipients should be assessed to determine the risk of infection and guide preventive measures. Table 89.2 lists the recommended screening tests in the evaluation of potential recipients (and their donors) prior to transplantation. Some candidates will be found to have active infection; these infections do not generally preclude transplantation, but they should be adequately controlled and treated prior to and after the transplant procedure. THE TRANSPLANT DONOR The epidemiologic exposures of transplant donors should be determined so that the potential for donor-derived infections is reduced.

Original languageEnglish (US)
Title of host publicationClinical Infectious Disease, Second Edition
PublisherCambridge University Press
Pages573-584
Number of pages12
ISBN (Print)9781139855952, 9781107038912
DOIs
StatePublished - Jan 1 2015

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Tissue Donors
Infection
Transplantation
Asymptomatic Infections
Organ Transplantation
Transplants
Tissue Transplantation
Transplant Recipients
Opportunistic Infections
Immunosuppressive Agents
Immunosuppression
Allografts
Incidence
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Razonable, R. R. (2015). Infections in transplant recipients. In Clinical Infectious Disease, Second Edition (pp. 573-584). Cambridge University Press. https://doi.org/10.1017/CBO9781139855952.101

Infections in transplant recipients. / Razonable, Raymund R.

Clinical Infectious Disease, Second Edition. Cambridge University Press, 2015. p. 573-584.

Research output: Chapter in Book/Report/Conference proceedingChapter

Razonable, RR 2015, Infections in transplant recipients. in Clinical Infectious Disease, Second Edition. Cambridge University Press, pp. 573-584. https://doi.org/10.1017/CBO9781139855952.101
Razonable RR. Infections in transplant recipients. In Clinical Infectious Disease, Second Edition. Cambridge University Press. 2015. p. 573-584 https://doi.org/10.1017/CBO9781139855952.101
Razonable, Raymund R. / Infections in transplant recipients. Clinical Infectious Disease, Second Edition. Cambridge University Press, 2015. pp. 573-584
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