TY - JOUR
T1 - Infantile, childhood, and adolescent epilepsies
AU - Wirrell, Elaine
N1 - Publisher Copyright:
Copyright © American Academy of Neurology.
PY - 2016/2/1
Y1 - 2016/2/1
N2 - Purpose of Review: Infantile, childhood, and adolescent epilepsies comprise a diverse group of entities. Careful characterization of epilepsy into a specific electroclinical syndrome or etiology assists greatly in understanding both the natural history of the seizure disorder (pharmacoresistant versus pharmacoresponsive and self-limited versus lifelong) and the best therapeutic options for the child. Recent Findings: Tremendous growth has been seen in the understanding of both genetic factors predisposing to epilepsy and neuroimaging techniques. Additionally, a number of studies have focused on the efficacy of certain therapies in specific syndromes or etiologies. Summary: This article reviews both common epilepsy syndromes (including benign focal epilepsy of childhood, absence epilepsy, and juvenile myoclonic epilepsy) and the rarer syndromes with associated management implications (eg, Dravet syndrome, progressive myoclonic epilepsy, and mitochondrial disorders) and addresses genetic and metabolic investigations.
AB - Purpose of Review: Infantile, childhood, and adolescent epilepsies comprise a diverse group of entities. Careful characterization of epilepsy into a specific electroclinical syndrome or etiology assists greatly in understanding both the natural history of the seizure disorder (pharmacoresistant versus pharmacoresponsive and self-limited versus lifelong) and the best therapeutic options for the child. Recent Findings: Tremendous growth has been seen in the understanding of both genetic factors predisposing to epilepsy and neuroimaging techniques. Additionally, a number of studies have focused on the efficacy of certain therapies in specific syndromes or etiologies. Summary: This article reviews both common epilepsy syndromes (including benign focal epilepsy of childhood, absence epilepsy, and juvenile myoclonic epilepsy) and the rarer syndromes with associated management implications (eg, Dravet syndrome, progressive myoclonic epilepsy, and mitochondrial disorders) and addresses genetic and metabolic investigations.
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U2 - 10.1212/CON.0000000000000269
DO - 10.1212/CON.0000000000000269
M3 - Review article
C2 - 26844731
AN - SCOPUS:84957703756
SN - 1080-2371
VL - 22
SP - 60
EP - 93
JO - CONTINUUM Lifelong Learning in Neurology
JF - CONTINUUM Lifelong Learning in Neurology
ER -