Induction of myasthenia gravis in HLA transgenic mice by immunization with human acetylcholine receptors

Huan Yang, Elzbieta Goluszko, Chella David, David K. Okita, Bianca Conti-Fine, Teh Sheng Chan, Mathilde A. Poussin, Premkumar Christadoss

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

We utilized HLA transgenic mice to identify the dominant epitopes on the human (H)-AChR α subunit. The cytoplasmic H-AChR peptide α320-337 was the dominant T cell epitope for DQ8, DR3, and DQ8XDQ6 F1 mice. The H-AChR-immunized HLA-DQ8, DR3, DQ8XDR3 F1 and DQ8XDQ6 F1 mice developed clinical EAMG, whereas HLA-DQ6 mice were less susceptible.

Original languageEnglish (US)
Pages (from-to)375-378
Number of pages4
JournalAnnals of the New York Academy of Sciences
Volume998
DOIs
StatePublished - 2003

Keywords

  • AChR
  • Experimental autoimmune myasthenia gravis (EAMG)
  • HLA transgenic mice
  • Myasthenia gravis (MG)

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science

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