Individualized Ablation of Hepatocellular Carcinoma: Tailored Approaches across the Phenotype Spectrum

Zlatko Devcic, Mohamed Elboraey, Lucas Vidal, Kabir Mody, Denise Harnois, Tushar Patel, Beau B. Toskich

Research output: Contribution to journalArticle

Abstract

Ablation is now recommended by international guidelines for the definitive treatment of hepatocellular carcinoma (HCC). Extensive clinical studies have demonstrated outcomes comparable to surgical resection with shorter hospital stays, decreased costs, and improved quality of life. Successful ablation requires complete treatment of both tumor and margin while preserving critical adjacent structures. HCC exhibits highly variable presentations in both anatomic involvement and biology which have significant implications on choice of ablative therapy. There are now abundant ablation modalities and adjunctive techniques which can be used to individualize ablation and maximize curative results. This article provides a patient-centered summary of approaches to HCC ablation in the context of patient performance, hepatic reserve, tumor phenotype and biology, intra- A nd extrahepatic anatomy, and ablation technology.

Original languageEnglish (US)
Pages (from-to)287-297
Number of pages11
JournalSeminars in Interventional Radiology
Volume36
Issue number4
DOIs
StatePublished - Jan 1 2019

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Hepatocellular Carcinoma
Phenotype
Length of Stay
Neoplasms
Anatomy
Therapeutics
Quality of Life
Guidelines
Technology
Costs and Cost Analysis
Liver
Clinical Studies

Keywords

  • ablation
  • hepatocellular carcinoma
  • locoregional therapy

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

Cite this

Individualized Ablation of Hepatocellular Carcinoma : Tailored Approaches across the Phenotype Spectrum. / Devcic, Zlatko; Elboraey, Mohamed; Vidal, Lucas; Mody, Kabir; Harnois, Denise; Patel, Tushar; Toskich, Beau B.

In: Seminars in Interventional Radiology, Vol. 36, No. 4, 01.01.2019, p. 287-297.

Research output: Contribution to journalArticle

Devcic, Zlatko ; Elboraey, Mohamed ; Vidal, Lucas ; Mody, Kabir ; Harnois, Denise ; Patel, Tushar ; Toskich, Beau B. / Individualized Ablation of Hepatocellular Carcinoma : Tailored Approaches across the Phenotype Spectrum. In: Seminars in Interventional Radiology. 2019 ; Vol. 36, No. 4. pp. 287-297.
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