TY - JOUR
T1 - Increasing incidence and mortality of primary intrahepatic cholangiocarcinoma in the United States
AU - Patel, Tushar
N1 - Funding Information:
Abbreviations: ICD-9-CM, International Classification of Diseases, 9th Revision, Clinical Modification; SEER, Surveillance, Epidemiology, and End Results; EAPC, estimated annual percent change; PSC, primary sclerosing cholangitis. From the Division of Gastroenterology, Scott and White Clinic, Texas A&M University System Health Science Center, College of Medicine, Temple, TX. Received December 14, 2000; accepted March 26, 2001. Supported in part by the Scott Sherwood and Brindley Foundation, and grant DK02678 from the National Institutes of Health. Address reprint requests to: Tushar Patel, M.D., Division of Gastroenterology, Scott and White Clinic, 2401 South 31st Street, Temple, TX 76508. E-mail: tpatel@medicine. tamu.edu; fax: 254-742-7180. Copyright © 2001 by the American Association for the Study of Liver Diseases. 0270-9139/01/3306-0003$35.00/0 doi:10.1053/jhep.2001.25087
PY - 2001
Y1 - 2001
N2 - Clinical observations suggest a recent increase in intrahepatic biliary tract malignancies. Thus, our aim was to determine recent trends in the epidemiology of intrahepatic cholangiocarcinoma in the United States. Reported data from the Surveillance, Epidemiology, and End Results (SEER) program and the United States Vital Statistics databases were analyzed to determine the incidence, mortality, and survival rates of primary intrahepatic cholangiocarcinoma. Between 1973 and 1997, the incidence and mortality rates from intrahepatic cholangiocarcinoma markedly increased, with an estimated annual percent change (EAPC) of 9.11% (95% CI, 7.46 to 10.78) and 9.44% (95%, CI 8.46 to 10.41), respectively. The age-adjusted mortality rate per 100,000 persons for whites increased from 0.14 for the period 1975-1979 to 0.65 for the period 1993-1997, and that for blacks increased from 0.15 to 0.58 over the same period. The increase in mortality was similar across all age groups above age 45. The relative 1- and 2-year survival rates following diagnosis from 1989 to 1996 were 24.5% and 12.8%, respectively. In conclusion, there has been a marked increase in the incidence and mortality from intrahepatic cholangiocarcinoma in the United States in recent years. This tumor continues to be associated with a poor prognosis.
AB - Clinical observations suggest a recent increase in intrahepatic biliary tract malignancies. Thus, our aim was to determine recent trends in the epidemiology of intrahepatic cholangiocarcinoma in the United States. Reported data from the Surveillance, Epidemiology, and End Results (SEER) program and the United States Vital Statistics databases were analyzed to determine the incidence, mortality, and survival rates of primary intrahepatic cholangiocarcinoma. Between 1973 and 1997, the incidence and mortality rates from intrahepatic cholangiocarcinoma markedly increased, with an estimated annual percent change (EAPC) of 9.11% (95% CI, 7.46 to 10.78) and 9.44% (95%, CI 8.46 to 10.41), respectively. The age-adjusted mortality rate per 100,000 persons for whites increased from 0.14 for the period 1975-1979 to 0.65 for the period 1993-1997, and that for blacks increased from 0.15 to 0.58 over the same period. The increase in mortality was similar across all age groups above age 45. The relative 1- and 2-year survival rates following diagnosis from 1989 to 1996 were 24.5% and 12.8%, respectively. In conclusion, there has been a marked increase in the incidence and mortality from intrahepatic cholangiocarcinoma in the United States in recent years. This tumor continues to be associated with a poor prognosis.
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U2 - 10.1053/jhep.2001.25087
DO - 10.1053/jhep.2001.25087
M3 - Article
C2 - 11391522
AN - SCOPUS:0034982536
SN - 0270-9139
VL - 33
SP - 1353
EP - 1357
JO - Hepatology
JF - Hepatology
IS - 6
ER -