TY - JOUR
T1 - Increased risk of serious pneumococcal disease in patients with atopic conditions other than asthma
AU - Jung, Ji A.
AU - Kita, Hirohito
AU - Yawn, Barbara P.
AU - Boyce, Thomas G.
AU - Yoo, Kwang H.
AU - McGree, Michaela E.
AU - Weaver, Amy L.
AU - Wollan, Peter
AU - Jacobson, Robert M.
AU - Juhn, Young J.
N1 - Funding Information:
Disclosure of potential conflict of interest: B. P. Yawn is a speaker and consultant for Prime Med and PCE and has received research support from the National Institutes of Health, the Centers for Disease Control and Prevention, the Agency for Healthcare Research and Quality, and GlaxoSmithKline. P. Wollan has received research support from Merck, the Centers for Disease Control and Prevention, and the Agency for Healthcare Research and Quality. R. M. Jacobson has received research support from Wyeth Pharmaceuticals. The rest of the authors have declared that they have no conflict of interest.
Funding Information:
Supported by an NIH grant ( R01 AI 56133 ) from the National Institute of Allergy and Infectious Diseases and made possible by the Rochester Epidemiology Project ( R01-AR30582 ) from the National Institute of Arthritis and Musculoskeletal and Skin Diseases .
PY - 2010/1
Y1 - 2010/1
N2 - Background: We reported an increased risk of serious pneumococcal disease (SPD) among patients with asthma. It is not known whether this is true for patients with other atopic conditions. Objective: To determine the relationship between atopic conditions other than asthma and SPD. Methods: The study subjects were residents of Rochester, Minn, who developed SPD between 1964 and 1983 and their 2 sex-matched and age-matched controls. We used a population-based computer-linked medical diagnosis system to identify all individuals with potential SPD. All records were reviewed by using explicit predetermined criteria for SPD. All individuals with atopic conditions were identified by the physician diagnoses including atopic dermatitis or eczema, allergic rhinitis, and hay fever documented in medical records. The associations between these atopic conditions and SPD were assessed by using conditional logistic regression. Results: A total of 3941 records were reviewed, and we identified 174 SPD cases. Of these 174 cases, 50.6% were male, and 94.3% were Caucasian. Twenty-six (14.9%) of the SPD cases and 29 (8.3%) of the controls had atopy. Atopic conditions other than asthma were associated with an increased risk of SPD (odds ratio, 2.13; 95% CI, 1.04-4.35; P = .04) after adjusting for smoking status, previous high-risk conditions for SPD, educational status, and ethnicity. Conclusion: Like asthma, other atopic conditions, particularly atopic dermatitis, are associated with an increased risk of SPD. There may be a common immunogenetic mechanism underlying increased risk of SPD among individuals with either asthma or other atopic conditions. Our study findings need to be studied further.
AB - Background: We reported an increased risk of serious pneumococcal disease (SPD) among patients with asthma. It is not known whether this is true for patients with other atopic conditions. Objective: To determine the relationship between atopic conditions other than asthma and SPD. Methods: The study subjects were residents of Rochester, Minn, who developed SPD between 1964 and 1983 and their 2 sex-matched and age-matched controls. We used a population-based computer-linked medical diagnosis system to identify all individuals with potential SPD. All records were reviewed by using explicit predetermined criteria for SPD. All individuals with atopic conditions were identified by the physician diagnoses including atopic dermatitis or eczema, allergic rhinitis, and hay fever documented in medical records. The associations between these atopic conditions and SPD were assessed by using conditional logistic regression. Results: A total of 3941 records were reviewed, and we identified 174 SPD cases. Of these 174 cases, 50.6% were male, and 94.3% were Caucasian. Twenty-six (14.9%) of the SPD cases and 29 (8.3%) of the controls had atopy. Atopic conditions other than asthma were associated with an increased risk of SPD (odds ratio, 2.13; 95% CI, 1.04-4.35; P = .04) after adjusting for smoking status, previous high-risk conditions for SPD, educational status, and ethnicity. Conclusion: Like asthma, other atopic conditions, particularly atopic dermatitis, are associated with an increased risk of SPD. There may be a common immunogenetic mechanism underlying increased risk of SPD among individuals with either asthma or other atopic conditions. Our study findings need to be studied further.
UR - http://www.scopus.com/inward/record.url?scp=73149115320&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=73149115320&partnerID=8YFLogxK
U2 - 10.1016/j.jaci.2009.10.045
DO - 10.1016/j.jaci.2009.10.045
M3 - Article
C2 - 20109748
AN - SCOPUS:73149115320
SN - 0091-6749
VL - 125
SP - 217
EP - 221
JO - Journal of Allergy and Clinical Immunology
JF - Journal of Allergy and Clinical Immunology
IS - 1-3
ER -