TY - JOUR
T1 - Increased brain glucose uptake after 12 weeks of aerobic high-intensity interval training in young and older adults
AU - Robinson, Matthew M.
AU - Lowe, Val J.
AU - Nair, K. Sreekumaran
N1 - Funding Information:
Financial Support: Funding was provided by National Institutes of Health Grants R01AG09531 (to K.S.N.) and T32DK7352 (M.M.R.) and by the Elsie and Marvin Dekelboum Family Foundation and institutional funds (to V.J.L.). Additional support was provided by the Mayo Foundation and the Murdock-Dole Professorship (to K.S.N.). This publication was made possible by the Mayo Clinic Metabolomics Resource Core through Grant U24DK100469 from the National Institute of Diabetes and Digestive and Kidney Diseases and Mayo Clinic Clinical and Translational Sciences Award (CTSA) Grant UL1TR000135 from the National Center for Advancing Translational Sciences (NCATs).
Funding Information:
We thank the participants for their time and enthusiasm during the project. We acknowledge the skillful assistance of Kera Hoff along with the staff of the Dan Abraham Healthy Living Center and Clinical Research Unit at Mayo Clinic. Funding was provided by National Institutes of Health Grants R01AG09531 (to K.S.N.) and T32DK7352 (M.M.R.) and by the Elsie and Marvin Dekelboum Family Foundation and institutional funds (to V.J.L.). Additional support was provided by the Mayo Foundation and the Murdock-Dole Professorship (to K.S.N.). This publication was made possible by the Mayo Clinic Metabolomics Resource Core through Grant U24DK100469 from the National Institute of Diabetes and Digestive and Kidney Diseases and Mayo Clinic Clinical and Translational Sciences Award (CTSA) Grant UL1TR000135 from the National Center for Advancing Translational Sciences (NCATs).
Publisher Copyright:
Copyright © 2018 Endocrine Society.
PY - 2018
Y1 - 2018
N2 - Context: Aerobic exercise training can increase brain volume and blood flow, but the impact on brain metabolism is less known. Objective: We determined whether high-intensity interval training (HIIT) increases brain metabolism by measuring brain glucose uptake in younger and older adults. Design: Brain glucose uptake was measured before and after HIIT or a sedentary (SED) control period within a larger exercise study. Setting: Study procedures were performed at the Mayo Clinic in Rochester, MN. Participants: Participants were younger (18 to 30 years) or older (65 to 80 years) SED adults who were free of major medical conditions. Group sizes were 15 for HIIT (nine younger and six older) and 12 for SED (six younger and six older). Intervention: Participants completed 12 weeks of HIIT or SED. HIIT was 3 days per week of 4 3 4 minute intervals at over 90% of peak aerobic capacity (VO2peak) with 2 days per week of treadmill walking at 70% VO2peak. Main Outcome Measures: Resting brain glucose uptake was measured using 18F-fluorodeoxyglucose positron emission tomography scans at baseline and at week 12. Scans were performed at 96 hours after exercise. VO2peak was measured by indirect calorimetry. Results: Glucose uptake increased significantly in the parietal-temporal and caudate regions after HIIT compared with SED. The gains with HIIT were not observed in all brain regions. VO2peak was increased for all participants after HIIT and did not change with SED. Conclusion: We demonstrate that brain glucose metabolism increased after 12 weeks of HIIT in adults in regions where it is reduced in Alzheimer’s disease. (J Clin Endocrinol Metab 103: 221–227, 2018)
AB - Context: Aerobic exercise training can increase brain volume and blood flow, but the impact on brain metabolism is less known. Objective: We determined whether high-intensity interval training (HIIT) increases brain metabolism by measuring brain glucose uptake in younger and older adults. Design: Brain glucose uptake was measured before and after HIIT or a sedentary (SED) control period within a larger exercise study. Setting: Study procedures were performed at the Mayo Clinic in Rochester, MN. Participants: Participants were younger (18 to 30 years) or older (65 to 80 years) SED adults who were free of major medical conditions. Group sizes were 15 for HIIT (nine younger and six older) and 12 for SED (six younger and six older). Intervention: Participants completed 12 weeks of HIIT or SED. HIIT was 3 days per week of 4 3 4 minute intervals at over 90% of peak aerobic capacity (VO2peak) with 2 days per week of treadmill walking at 70% VO2peak. Main Outcome Measures: Resting brain glucose uptake was measured using 18F-fluorodeoxyglucose positron emission tomography scans at baseline and at week 12. Scans were performed at 96 hours after exercise. VO2peak was measured by indirect calorimetry. Results: Glucose uptake increased significantly in the parietal-temporal and caudate regions after HIIT compared with SED. The gains with HIIT were not observed in all brain regions. VO2peak was increased for all participants after HIIT and did not change with SED. Conclusion: We demonstrate that brain glucose metabolism increased after 12 weeks of HIIT in adults in regions where it is reduced in Alzheimer’s disease. (J Clin Endocrinol Metab 103: 221–227, 2018)
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U2 - 10.1210/jc.2017-01571
DO - 10.1210/jc.2017-01571
M3 - Article
C2 - 29077855
AN - SCOPUS:85045887007
VL - 103
SP - 221
EP - 227
JO - Journal of Clinical Endocrinology and Metabolism
JF - Journal of Clinical Endocrinology and Metabolism
SN - 0021-972X
IS - 1
ER -