Incorporation of pharmacogenomics into routine clinical practice: The clinical pharmacogenetics implementation consortium (CPIC) guideline development process

Kelly E. Caudle; Teri E. Klein; James M. Hoffman; Daniel J. Müller; Michelle Whirl-Carrillo; Li Gong; Ellen M. McDonagh; Katrin Sangkuhl; Caroline F. Thorn; Matthias Schwab; José A.G. Agúndez; Robert R. Freimuth; Vojtech Huser; Ming Ta Michael Lee; Otito F. Iwuchukwu; Kristine R. Crews; Stuart A. Scott; Mia Wadelius; Jesse J. Swen; Rachel F. Tyndale; C. Michael Stein; Dan Roden; Mary V. Relling; Marc S. Williams; Samuel G. Johnson

doi:10.2174/1389200215666140130124910

Incorporation of pharmacogenomics into routine clinical practice: The clinical pharmacogenetics implementation consortium (CPIC) guideline development process

Kelly E. Caudle, Teri E. Klein, James M. Hoffman, Daniel J. Müller, Michelle Whirl-Carrillo, Li Gong, Ellen M. McDonagh, Katrin Sangkuhl, Caroline F. Thorn, Matthias Schwab, José A.G. Agúndez, Robert R. Freimuth, Vojtech Huser, Ming Ta Michael Lee, Otito F. Iwuchukwu, Kristine R. Crews, Stuart A. Scott, Mia Wadelius, Jesse J. Swen, Rachel F. TyndaleC. Michael Stein, Dan Roden, Mary V. Relling, Marc S. Williams, Samuel G. Johnson

Quantitative Health Sciences

Research output: Contribution to journal › Review article › peer-review

220 Scopus citations

Abstract

The Clinical Pharmacogenetics Implementation Consortium (CPIC) publishes genotype-based drug guidelines to help clinicians understand how available genetic test results could be used to optimize drug therapy. CPIC has focused initially on well-known examples of pharmacogenomic associations that have been implemented in selected clinical settings, publishing nine to date. Each CPIC guideline adheres to a standardized format and includes a standard system for grading levels of evidence linking genotypes to phenotypes and assigning a level of strength to each prescribing recommendation. CPIC guidelines contain the necessary information to help clinicians translate patient-specific diplotypes for each gene into clinical phenotypes or drug dosing groups. This paper reviews the development process of the CPIC guidelines and compares this process to the Institute of Medicine's Standards for Developing Trustworthy Clinical Practice Guidelines.

Original language	English (US)
Pages (from-to)	209-217
Number of pages	9
Journal	Current Drug Metabolism
Volume	15
Issue number	2
DOIs	https://doi.org/10.2174/1389200215666140130124910
State	Published - Feb 2014

Keywords

Clinical practice guideline
Guideline
Pharmacogenetics
Pharmacogenomics

ASJC Scopus subject areas

General Medicine

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10.2174/1389200215666140130124910

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Caudle, K. E., Klein, T. E., Hoffman, J. M., Müller, D. J., Whirl-Carrillo, M., Gong, L., McDonagh, E. M., Sangkuhl, K., Thorn, C. F., Schwab, M., Agúndez, J. A. G., Freimuth, R. R., Huser, V., Lee, M. T. M., Iwuchukwu, O. F., Crews, K. R., Scott, S. A., Wadelius, M., Swen, J. J., ... Johnson, S. G. (2014). Incorporation of pharmacogenomics into routine clinical practice: The clinical pharmacogenetics implementation consortium (CPIC) guideline development process. Current Drug Metabolism, 15(2), 209-217. https://doi.org/10.2174/1389200215666140130124910

Caudle, KE, Klein, TE, Hoffman, JM, Müller, DJ, Whirl-Carrillo, M, Gong, L, McDonagh, EM, Sangkuhl, K, Thorn, CF, Schwab, M, Agúndez, JAG, Freimuth, RR, Huser, V, Lee, MTM, Iwuchukwu, OF, Crews, KR, Scott, SA, Wadelius, M, Swen, JJ, Tyndale, RF, Stein, CM, Roden, D, Relling, MV, Williams, MS & Johnson, SG 2014, 'Incorporation of pharmacogenomics into routine clinical practice: The clinical pharmacogenetics implementation consortium (CPIC) guideline development process', Current Drug Metabolism, vol. 15, no. 2, pp. 209-217. https://doi.org/10.2174/1389200215666140130124910

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abstract = "The Clinical Pharmacogenetics Implementation Consortium (CPIC) publishes genotype-based drug guidelines to help clinicians understand how available genetic test results could be used to optimize drug therapy. CPIC has focused initially on well-known examples of pharmacogenomic associations that have been implemented in selected clinical settings, publishing nine to date. Each CPIC guideline adheres to a standardized format and includes a standard system for grading levels of evidence linking genotypes to phenotypes and assigning a level of strength to each prescribing recommendation. CPIC guidelines contain the necessary information to help clinicians translate patient-specific diplotypes for each gene into clinical phenotypes or drug dosing groups. This paper reviews the development process of the CPIC guidelines and compares this process to the Institute of Medicine's Standards for Developing Trustworthy Clinical Practice Guidelines.",

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AU - Scott, Stuart A.

AU - Wadelius, Mia

AU - Swen, Jesse J.

AU - Tyndale, Rachel F.

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Incorporation of pharmacogenomics into routine clinical practice: The clinical pharmacogenetics implementation consortium (CPIC) guideline development process

Abstract

Keywords

ASJC Scopus subject areas

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