TY - JOUR
T1 - Incidence of Presentation of Common Functional Gastrointestinal Disorders in Children From Birth to 5 Years
T2 - A Cohort Study
AU - Chitkara, Denesh K.
AU - Talley, Nicholas J.
AU - Weaver, Amy L.
AU - Katusic, Slavica K.
AU - De Schepper, Heiko
AU - Rucker, Mary Jo
AU - Locke, G. Richard
N1 - Funding Information:
Supported in part by a research grant from Novartis Pharmaceuticals and the Mayo Family Endowment in Gastroenterology at Children’s Hospital, Boston. Nicholas J. Talley has served as a Consultant to Altana, AstraZeneca, Axcan, Chugai, EB Med, Giaconda, GlaxoSmithKline, Kosan, KV Pharmaceuticals, Medscape, ProEd Communications, Renovis, Inc., Solvay, Strategic Consultants International, Takeda Pharmaceuticals, Inc., TAP Pharmaceuticals, Inc., Therapeutic Gastrointestinal Group, Theravance, and Yamanouchi, and he has received research support from Merck, Novartis, TAP Pharmaceuticals, Axcan, Bohringer-Ingleheim, and Forest. G. Richard Locke III is a Consultant to Bohringer-Ingleheim and was a Consultant to Novartis and Solvay. He receives research support from Novartis and previously from AstraZeneca, Forest Laboratories, GlaxoSmithKline, and Janssen Pharmaceutica.
PY - 2007/2
Y1 - 2007/2
N2 - Background & Aims: Gastroesophageal reflux disease (GERD), abdominal pain of unknown origin, and constipation are thought to be causes for frequent medical visits during childhood. The aim of this study was to estimate the incidences, repeat presentation, clinical symptoms, and sociodemographic risk factors in children who medically presented for GERD, abdominal pain of unknown origin, and constipation from birth to 5 years. Methods: This was a population-based, retrospective birth cohort study of all children born to mothers residing in Rochester, Minnesota who remained in the area until at least age 5 (n = 5718). The medical records of all individuals were searched for relevant diagnostic billing codes for GERD, abdominal pain of unknown origin, and constipation, without another underlying diagnosis, and manually reviewed. Parental sociodemographic factors collected from birth certificate records on patients and matched controls were compared. Results: The incidence for childhood (age, <5 y) presentation of GERD, abdominal pain of unknown origin, and constipation was .9/1000 person-years, 4.5/1000 person-years, and 6.8/1000 person-years, respectively; there were no significant differences between boys and girls. Three or more medical visits by age 5 occurred in 11%, 19%, and 24% of children who were seen for abdominal pain of unknown origin, constipation, and GERD, respectively. Single parentage, maternal age (<18 y), and maternal education (
AB - Background & Aims: Gastroesophageal reflux disease (GERD), abdominal pain of unknown origin, and constipation are thought to be causes for frequent medical visits during childhood. The aim of this study was to estimate the incidences, repeat presentation, clinical symptoms, and sociodemographic risk factors in children who medically presented for GERD, abdominal pain of unknown origin, and constipation from birth to 5 years. Methods: This was a population-based, retrospective birth cohort study of all children born to mothers residing in Rochester, Minnesota who remained in the area until at least age 5 (n = 5718). The medical records of all individuals were searched for relevant diagnostic billing codes for GERD, abdominal pain of unknown origin, and constipation, without another underlying diagnosis, and manually reviewed. Parental sociodemographic factors collected from birth certificate records on patients and matched controls were compared. Results: The incidence for childhood (age, <5 y) presentation of GERD, abdominal pain of unknown origin, and constipation was .9/1000 person-years, 4.5/1000 person-years, and 6.8/1000 person-years, respectively; there were no significant differences between boys and girls. Three or more medical visits by age 5 occurred in 11%, 19%, and 24% of children who were seen for abdominal pain of unknown origin, constipation, and GERD, respectively. Single parentage, maternal age (<18 y), and maternal education (
UR - http://www.scopus.com/inward/record.url?scp=33846798131&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33846798131&partnerID=8YFLogxK
U2 - 10.1016/j.cgh.2006.06.012
DO - 10.1016/j.cgh.2006.06.012
M3 - Article
C2 - 16901769
AN - SCOPUS:33846798131
SN - 1542-3565
VL - 5
SP - 186
EP - 191
JO - Clinical Gastroenterology and Hepatology
JF - Clinical Gastroenterology and Hepatology
IS - 2
ER -