Incidence and predictors of myocardial infarction after transient ischemic attack: A population-based study

Joseph D. Burns, Alejandro Rabinstein, Veronique Lee Roger, Latha G. Stead, Teresa J H Christianson, Jill M. Killian, Robert D Jr. Brown

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Background and Purpose- Coronary artery disease is the leading cause of death after TIA. Reliable estimates of the risk of MI after TIA, however, are lacking. Methods- Our purpose was to determine the incidence of and risk factors for MI after TIA. We cross-referenced preexisting incidence cohorts from the Rochester Epidemiology Project for TIA (1985-1994) and MI (1979-2006) to identify all community residents with incident MI after incident TIA. Incidence of MI after TIA was determined using Kaplan-Meier life-table methods. This was compared to the age-, sex-, and period-specific MI incidences in the general population. Proportional hazards regression analysis was used to examine associations between clinical variables and the occurrence of MI after TIA. Results- Average annual incidence of MI after TIA was 0.95%. Relative risk for incident MI in the TIA cohort compared to the general population was 2.09 (95% CI, 1.52-2.81). This was highest in patients younger than 60 years old (relative risk, 15.1; 95% CI, 4.11-38.6). Increasing age (hazard ratio, 1.51 per 10 years; 95% CI, 1.14-2.01), male sex (hazard ratio, 2.19; 95% CI, 1.18-4.06), and the use of lipid-lowering therapy at the time of TIA (hazard ratio, 3.10; 95% CI, 1.20-8.00) were independent risk factors for MI after TIA. Conclusions- Average annual incidence of MI after TIA is 1%, approximately double that of the general population. The relative risk increase is especially high in patients younger than 60 years old. These data are useful for identifying subgroups of patients with TIA at highest risk for subsequent MI.

Original languageEnglish (US)
Pages (from-to)935-940
Number of pages6
JournalStroke
Volume42
Issue number4
DOIs
StatePublished - Apr 2011

Fingerprint

Transient Ischemic Attack
Myocardial Infarction
Incidence
Population
Life Tables
Sex Ratio
Coronary Artery Disease
Cause of Death
Epidemiology
Regression Analysis
Lipids

Keywords

  • incidence
  • mortality
  • myocardial infarction
  • risk factors
  • transient ischemic attack

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Clinical Neurology
  • Advanced and Specialized Nursing

Cite this

Incidence and predictors of myocardial infarction after transient ischemic attack : A population-based study. / Burns, Joseph D.; Rabinstein, Alejandro; Roger, Veronique Lee; Stead, Latha G.; Christianson, Teresa J H; Killian, Jill M.; Brown, Robert D Jr.

In: Stroke, Vol. 42, No. 4, 04.2011, p. 935-940.

Research output: Contribution to journalArticle

Burns, Joseph D. ; Rabinstein, Alejandro ; Roger, Veronique Lee ; Stead, Latha G. ; Christianson, Teresa J H ; Killian, Jill M. ; Brown, Robert D Jr. / Incidence and predictors of myocardial infarction after transient ischemic attack : A population-based study. In: Stroke. 2011 ; Vol. 42, No. 4. pp. 935-940.
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abstract = "Background and Purpose- Coronary artery disease is the leading cause of death after TIA. Reliable estimates of the risk of MI after TIA, however, are lacking. Methods- Our purpose was to determine the incidence of and risk factors for MI after TIA. We cross-referenced preexisting incidence cohorts from the Rochester Epidemiology Project for TIA (1985-1994) and MI (1979-2006) to identify all community residents with incident MI after incident TIA. Incidence of MI after TIA was determined using Kaplan-Meier life-table methods. This was compared to the age-, sex-, and period-specific MI incidences in the general population. Proportional hazards regression analysis was used to examine associations between clinical variables and the occurrence of MI after TIA. Results- Average annual incidence of MI after TIA was 0.95{\%}. Relative risk for incident MI in the TIA cohort compared to the general population was 2.09 (95{\%} CI, 1.52-2.81). This was highest in patients younger than 60 years old (relative risk, 15.1; 95{\%} CI, 4.11-38.6). Increasing age (hazard ratio, 1.51 per 10 years; 95{\%} CI, 1.14-2.01), male sex (hazard ratio, 2.19; 95{\%} CI, 1.18-4.06), and the use of lipid-lowering therapy at the time of TIA (hazard ratio, 3.10; 95{\%} CI, 1.20-8.00) were independent risk factors for MI after TIA. Conclusions- Average annual incidence of MI after TIA is 1{\%}, approximately double that of the general population. The relative risk increase is especially high in patients younger than 60 years old. These data are useful for identifying subgroups of patients with TIA at highest risk for subsequent MI.",
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T1 - Incidence and predictors of myocardial infarction after transient ischemic attack

T2 - A population-based study

AU - Burns, Joseph D.

AU - Rabinstein, Alejandro

AU - Roger, Veronique Lee

AU - Stead, Latha G.

AU - Christianson, Teresa J H

AU - Killian, Jill M.

AU - Brown, Robert D Jr.

PY - 2011/4

Y1 - 2011/4

N2 - Background and Purpose- Coronary artery disease is the leading cause of death after TIA. Reliable estimates of the risk of MI after TIA, however, are lacking. Methods- Our purpose was to determine the incidence of and risk factors for MI after TIA. We cross-referenced preexisting incidence cohorts from the Rochester Epidemiology Project for TIA (1985-1994) and MI (1979-2006) to identify all community residents with incident MI after incident TIA. Incidence of MI after TIA was determined using Kaplan-Meier life-table methods. This was compared to the age-, sex-, and period-specific MI incidences in the general population. Proportional hazards regression analysis was used to examine associations between clinical variables and the occurrence of MI after TIA. Results- Average annual incidence of MI after TIA was 0.95%. Relative risk for incident MI in the TIA cohort compared to the general population was 2.09 (95% CI, 1.52-2.81). This was highest in patients younger than 60 years old (relative risk, 15.1; 95% CI, 4.11-38.6). Increasing age (hazard ratio, 1.51 per 10 years; 95% CI, 1.14-2.01), male sex (hazard ratio, 2.19; 95% CI, 1.18-4.06), and the use of lipid-lowering therapy at the time of TIA (hazard ratio, 3.10; 95% CI, 1.20-8.00) were independent risk factors for MI after TIA. Conclusions- Average annual incidence of MI after TIA is 1%, approximately double that of the general population. The relative risk increase is especially high in patients younger than 60 years old. These data are useful for identifying subgroups of patients with TIA at highest risk for subsequent MI.

AB - Background and Purpose- Coronary artery disease is the leading cause of death after TIA. Reliable estimates of the risk of MI after TIA, however, are lacking. Methods- Our purpose was to determine the incidence of and risk factors for MI after TIA. We cross-referenced preexisting incidence cohorts from the Rochester Epidemiology Project for TIA (1985-1994) and MI (1979-2006) to identify all community residents with incident MI after incident TIA. Incidence of MI after TIA was determined using Kaplan-Meier life-table methods. This was compared to the age-, sex-, and period-specific MI incidences in the general population. Proportional hazards regression analysis was used to examine associations between clinical variables and the occurrence of MI after TIA. Results- Average annual incidence of MI after TIA was 0.95%. Relative risk for incident MI in the TIA cohort compared to the general population was 2.09 (95% CI, 1.52-2.81). This was highest in patients younger than 60 years old (relative risk, 15.1; 95% CI, 4.11-38.6). Increasing age (hazard ratio, 1.51 per 10 years; 95% CI, 1.14-2.01), male sex (hazard ratio, 2.19; 95% CI, 1.18-4.06), and the use of lipid-lowering therapy at the time of TIA (hazard ratio, 3.10; 95% CI, 1.20-8.00) were independent risk factors for MI after TIA. Conclusions- Average annual incidence of MI after TIA is 1%, approximately double that of the general population. The relative risk increase is especially high in patients younger than 60 years old. These data are useful for identifying subgroups of patients with TIA at highest risk for subsequent MI.

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KW - mortality

KW - myocardial infarction

KW - risk factors

KW - transient ischemic attack

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