Incidence and mortality of obstructive lung disease in rheumatoid arthritis: A population-based study

Carlotta Nannini, Yimy F. Medina-Velasquez, Sara J. Achenbach, Cynthia Crowson, Jay H Ryu, Robert Vassallo, Sherine E. Gabriel, Eric Lawrence Matteson, Tim Bongartz

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

Objective Pulmonary disease represents an important extraarticular manifestation of rheumatoid arthritis (RA). While the association of RA and interstitial lung disease is widely acknowledged, obstructive lung disease (OLD) in RA is less well understood. We therefore aimed to assess the incidence, risk factors, and mortality of OLD in patients with RA. Methods We examined a population-based incident cohort of patients with RA and a comparison cohort of individuals without RA. OLD was defined using a strict composite criterion. Cox proportional hazards models were used to compare OLD incidence between the RA and comparator cohorts to investigate risk factors and to explore the impact of OLD on patient survival. Results A total of 594 patients with RA and 596 subjects without RA were followed for a mean of 16.3 and 19.4 years, respectively. The lifetime risk of developing OLD was 9.6% for RA patients and 6.2% for subjects without RA (hazard ratio [HR] 1.54, 95% confidence interval [95% CI] 1.01-2.34). The risk of developing OLD was higher among male patients, among current or former smokers, and for individuals with more severe RA. Survival of RA patients diagnosed with OLD was worse compared to those without OLD (HR 2.09, 95% CI 1.47-2.97). Conclusion Patients with RA are at higher risk of developing OLD, which is significantly associated with premature mortality. Effective diagnostic and therapeutic strategies to detect and manage OLD in patients with RA may help to improve survival in these patients.

Original languageEnglish (US)
Pages (from-to)1243-1250
Number of pages8
JournalArthritis Care and Research
Volume65
Issue number8
DOIs
StatePublished - Aug 2013

Fingerprint

Obstructive Lung Diseases
Rheumatoid Arthritis
Mortality
Incidence
Population
Survival
Confidence Intervals
Premature Mortality
Interstitial Lung Diseases

ASJC Scopus subject areas

  • Rheumatology

Cite this

Incidence and mortality of obstructive lung disease in rheumatoid arthritis : A population-based study. / Nannini, Carlotta; Medina-Velasquez, Yimy F.; Achenbach, Sara J.; Crowson, Cynthia; Ryu, Jay H; Vassallo, Robert; Gabriel, Sherine E.; Matteson, Eric Lawrence; Bongartz, Tim.

In: Arthritis Care and Research, Vol. 65, No. 8, 08.2013, p. 1243-1250.

Research output: Contribution to journalArticle

Nannini, Carlotta ; Medina-Velasquez, Yimy F. ; Achenbach, Sara J. ; Crowson, Cynthia ; Ryu, Jay H ; Vassallo, Robert ; Gabriel, Sherine E. ; Matteson, Eric Lawrence ; Bongartz, Tim. / Incidence and mortality of obstructive lung disease in rheumatoid arthritis : A population-based study. In: Arthritis Care and Research. 2013 ; Vol. 65, No. 8. pp. 1243-1250.
@article{5fa59c1847e149149e7541f3aab280a8,
title = "Incidence and mortality of obstructive lung disease in rheumatoid arthritis: A population-based study",
abstract = "Objective Pulmonary disease represents an important extraarticular manifestation of rheumatoid arthritis (RA). While the association of RA and interstitial lung disease is widely acknowledged, obstructive lung disease (OLD) in RA is less well understood. We therefore aimed to assess the incidence, risk factors, and mortality of OLD in patients with RA. Methods We examined a population-based incident cohort of patients with RA and a comparison cohort of individuals without RA. OLD was defined using a strict composite criterion. Cox proportional hazards models were used to compare OLD incidence between the RA and comparator cohorts to investigate risk factors and to explore the impact of OLD on patient survival. Results A total of 594 patients with RA and 596 subjects without RA were followed for a mean of 16.3 and 19.4 years, respectively. The lifetime risk of developing OLD was 9.6{\%} for RA patients and 6.2{\%} for subjects without RA (hazard ratio [HR] 1.54, 95{\%} confidence interval [95{\%} CI] 1.01-2.34). The risk of developing OLD was higher among male patients, among current or former smokers, and for individuals with more severe RA. Survival of RA patients diagnosed with OLD was worse compared to those without OLD (HR 2.09, 95{\%} CI 1.47-2.97). Conclusion Patients with RA are at higher risk of developing OLD, which is significantly associated with premature mortality. Effective diagnostic and therapeutic strategies to detect and manage OLD in patients with RA may help to improve survival in these patients.",
author = "Carlotta Nannini and Medina-Velasquez, {Yimy F.} and Achenbach, {Sara J.} and Cynthia Crowson and Ryu, {Jay H} and Robert Vassallo and Gabriel, {Sherine E.} and Matteson, {Eric Lawrence} and Tim Bongartz",
year = "2013",
month = "8",
doi = "10.1002/acr.21986",
language = "English (US)",
volume = "65",
pages = "1243--1250",
journal = "Arthritis and Rheumatology",
issn = "2326-5191",
publisher = "John Wiley and Sons Ltd",
number = "8",

}

TY - JOUR

T1 - Incidence and mortality of obstructive lung disease in rheumatoid arthritis

T2 - A population-based study

AU - Nannini, Carlotta

AU - Medina-Velasquez, Yimy F.

AU - Achenbach, Sara J.

AU - Crowson, Cynthia

AU - Ryu, Jay H

AU - Vassallo, Robert

AU - Gabriel, Sherine E.

AU - Matteson, Eric Lawrence

AU - Bongartz, Tim

PY - 2013/8

Y1 - 2013/8

N2 - Objective Pulmonary disease represents an important extraarticular manifestation of rheumatoid arthritis (RA). While the association of RA and interstitial lung disease is widely acknowledged, obstructive lung disease (OLD) in RA is less well understood. We therefore aimed to assess the incidence, risk factors, and mortality of OLD in patients with RA. Methods We examined a population-based incident cohort of patients with RA and a comparison cohort of individuals without RA. OLD was defined using a strict composite criterion. Cox proportional hazards models were used to compare OLD incidence between the RA and comparator cohorts to investigate risk factors and to explore the impact of OLD on patient survival. Results A total of 594 patients with RA and 596 subjects without RA were followed for a mean of 16.3 and 19.4 years, respectively. The lifetime risk of developing OLD was 9.6% for RA patients and 6.2% for subjects without RA (hazard ratio [HR] 1.54, 95% confidence interval [95% CI] 1.01-2.34). The risk of developing OLD was higher among male patients, among current or former smokers, and for individuals with more severe RA. Survival of RA patients diagnosed with OLD was worse compared to those without OLD (HR 2.09, 95% CI 1.47-2.97). Conclusion Patients with RA are at higher risk of developing OLD, which is significantly associated with premature mortality. Effective diagnostic and therapeutic strategies to detect and manage OLD in patients with RA may help to improve survival in these patients.

AB - Objective Pulmonary disease represents an important extraarticular manifestation of rheumatoid arthritis (RA). While the association of RA and interstitial lung disease is widely acknowledged, obstructive lung disease (OLD) in RA is less well understood. We therefore aimed to assess the incidence, risk factors, and mortality of OLD in patients with RA. Methods We examined a population-based incident cohort of patients with RA and a comparison cohort of individuals without RA. OLD was defined using a strict composite criterion. Cox proportional hazards models were used to compare OLD incidence between the RA and comparator cohorts to investigate risk factors and to explore the impact of OLD on patient survival. Results A total of 594 patients with RA and 596 subjects without RA were followed for a mean of 16.3 and 19.4 years, respectively. The lifetime risk of developing OLD was 9.6% for RA patients and 6.2% for subjects without RA (hazard ratio [HR] 1.54, 95% confidence interval [95% CI] 1.01-2.34). The risk of developing OLD was higher among male patients, among current or former smokers, and for individuals with more severe RA. Survival of RA patients diagnosed with OLD was worse compared to those without OLD (HR 2.09, 95% CI 1.47-2.97). Conclusion Patients with RA are at higher risk of developing OLD, which is significantly associated with premature mortality. Effective diagnostic and therapeutic strategies to detect and manage OLD in patients with RA may help to improve survival in these patients.

UR - http://www.scopus.com/inward/record.url?scp=84881363540&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84881363540&partnerID=8YFLogxK

U2 - 10.1002/acr.21986

DO - 10.1002/acr.21986

M3 - Article

C2 - 23436637

AN - SCOPUS:84881363540

VL - 65

SP - 1243

EP - 1250

JO - Arthritis and Rheumatology

JF - Arthritis and Rheumatology

SN - 2326-5191

IS - 8

ER -