Incidence and distribution of parkinsonism in Olmsted County, Minnesota, 1976-1990

James Howard Bower, Demetrius M. Maraganore, Shannon K. McDonnell, Walter A Rocca

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Abstract

Objective: Limited information is available on the frequency and distribution of parkinsonism as a syndrome. We studied the incidence of parkinsonism and its specific types among residents of Olmsted County, MN, for the period from 1976 through 1990. Methods: We used the medical records linkage-system of the Rochester Epidemiology Project to identify all individuals whose records contained documentation of any form of parkinsonism, related, neurodegenerative diseases, or tremor of any type. A nurse abstractor screened the records, and, when applicable, a neurologist reviewed them to determine the presence of parkinsonism using specified diagnostic criteria and to define the year of onset. Results: We found 364 incident cases of parkinsonism: 154 with PD (42%), 72 with drug-induced parkinsonism (20%), 61 unspecified (17%), 51 with parkinsonism in dementia (14%), and 26 with other causes (7%). The average annual incidence rate of parkinsonism (per 100,000 person-years) in the age group 50 to 99 years was 114.7; incidence increased steeply with age from 0.8 in the age group 0 to 29 years to 304.8 in the age group 80 to 99 years. The cumulative incidence of parkinsonism assuming no competing causes of death was 7.5% to age 90 years. PD was the most common type of parkinsonism, followed by parkinsonism in dementia in men and drug-induced parkinsonism in women. Men had higher incidence than women at all ages for all types of parkinsonism except drug- induced. Conclusions: Parkinsonism is a common disease among the elderly; its incidence increases steeply with advancing age and is consistently higher in men. The distribution by type changes with age and gender.

Original languageEnglish (US)
Pages (from-to)1214-1220
Number of pages7
JournalNeurology
Volume52
Issue number6
StatePublished - Apr 12 1999

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Parkinsonian Disorders
Incidence
Age Groups
Dementia
Medical Record Linkage
Pharmaceutical Preparations
Tremor
Neurodegenerative Diseases
Documentation
Cause of Death
Epidemiology

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Incidence and distribution of parkinsonism in Olmsted County, Minnesota, 1976-1990. / Bower, James Howard; Maraganore, Demetrius M.; McDonnell, Shannon K.; Rocca, Walter A.

In: Neurology, Vol. 52, No. 6, 12.04.1999, p. 1214-1220.

Research output: Contribution to journalArticle

Bower, James Howard ; Maraganore, Demetrius M. ; McDonnell, Shannon K. ; Rocca, Walter A. / Incidence and distribution of parkinsonism in Olmsted County, Minnesota, 1976-1990. In: Neurology. 1999 ; Vol. 52, No. 6. pp. 1214-1220.
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