Kiechle et al. present two transgenic mouse models that allow direct quantitative and spatial detection of α-synuclein (α-syn) oligomers in vivo. They demonstrate α-syn aggregation at the synapse, age-dependent accumulation of 8–16-mer α-syn oligomer species, and trans-cellular oligomer spreading from forebrain to hindbrain neurons.
- Parkinson's disease
- progressive phenotype
- protein-fragment complementation
- synaptic oligomers
- transgenic mouse model
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)