In vivo CART cell imaging: Paving the way for success in CART cell therapy

Reona Sakemura, Ismail Can, Elizabeth L. Siegler, Saad S. Kenderian

Research output: Contribution to journalReview articlepeer-review

Abstract

Chimeric antigen receptor T (CART) cells are a promising immunotherapy that has induced dramatic anti-tumor responses in certain B cell malignancies. However, CART cell expansion and trafficking are often insufficient to yield long-term remissions, and serious toxicities can arise after CART cell administration. Visualizing CART cell expansion and trafficking in patients can detect an inadequate CART cell response or serve as an early warning for toxicity development, allowing CART cell treatment to be tailored accordingly to maximize therapeutic benefits. To this end, various imaging platforms are being developed to track CART cells in vivo, including nonspecific strategies to image activated T cells and reporter systems to specifically detect engineered T cells. Many of these platforms are clinically applicable and hold promise to provide valuable information and guide improved CART cell treatment.

Original languageEnglish (US)
Pages (from-to)625-633
Number of pages9
JournalMolecular Therapy - Oncolytics
Volume20
DOIs
StatePublished - Mar 26 2021

ASJC Scopus subject areas

  • Molecular Medicine
  • Oncology
  • Cancer Research
  • Pharmacology (medical)

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