In vitro migration and proliferation of human osteoblasts in injectable in situ crosslinkable poly(caprolactone fumarate) scaffolds

Esmaiel Jabbari, Theresa E. Hefferan, Lichun Lu, Larry G. Pedersen, Bradford L. Currier, Michael J Yaszemski

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The in vitro proliferation and migration of human osteoblasts in porous poly(caprolactone fumarate) (PCLF) scaffolds were investigated. PCLF was synthesized by condensation polymerization of PCL with fumaryl chloride in methylene chloride with triethylamine as the catalyst. Scaffolds were fabricated from the PCLF copolymer with salt as the porogen, and dimethyltoluidine (DMT) as the accelerator. NMR and FTIR were used to confirm the presence of the fumarate group in the PCLF macromers. The results from cell migration study with confocal microscopy show that PCLF, as an injectable and in-situ crosslinkable scaffold, supports osteoblast attachment, migration, and proliferation in vitro.

Original languageEnglish (US)
Title of host publicationAIChE Annual Meeting, Conference Proceedings
Pages1129-1131
Number of pages3
StatePublished - 2004
Event2004 AIChE Annual Meeting - Austin, TX, United States
Duration: Nov 7 2004Nov 12 2004

Other

Other2004 AIChE Annual Meeting
CountryUnited States
CityAustin, TX
Period11/7/0411/12/04

Fingerprint

Osteoblasts
Scaffolds
Confocal microscopy
Dichloromethane
Polycondensation
Particle accelerators
Copolymers
Nuclear magnetic resonance
Salts
Catalysts

ASJC Scopus subject areas

  • Engineering(all)

Cite this

Jabbari, E., Hefferan, T. E., Lu, L., Pedersen, L. G., Currier, B. L., & Yaszemski, M. J. (2004). In vitro migration and proliferation of human osteoblasts in injectable in situ crosslinkable poly(caprolactone fumarate) scaffolds. In AIChE Annual Meeting, Conference Proceedings (pp. 1129-1131). [68b]

In vitro migration and proliferation of human osteoblasts in injectable in situ crosslinkable poly(caprolactone fumarate) scaffolds. / Jabbari, Esmaiel; Hefferan, Theresa E.; Lu, Lichun; Pedersen, Larry G.; Currier, Bradford L.; Yaszemski, Michael J.

AIChE Annual Meeting, Conference Proceedings. 2004. p. 1129-1131 68b.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Jabbari, E, Hefferan, TE, Lu, L, Pedersen, LG, Currier, BL & Yaszemski, MJ 2004, In vitro migration and proliferation of human osteoblasts in injectable in situ crosslinkable poly(caprolactone fumarate) scaffolds. in AIChE Annual Meeting, Conference Proceedings., 68b, pp. 1129-1131, 2004 AIChE Annual Meeting, Austin, TX, United States, 11/7/04.
Jabbari E, Hefferan TE, Lu L, Pedersen LG, Currier BL, Yaszemski MJ. In vitro migration and proliferation of human osteoblasts in injectable in situ crosslinkable poly(caprolactone fumarate) scaffolds. In AIChE Annual Meeting, Conference Proceedings. 2004. p. 1129-1131. 68b
Jabbari, Esmaiel ; Hefferan, Theresa E. ; Lu, Lichun ; Pedersen, Larry G. ; Currier, Bradford L. ; Yaszemski, Michael J. / In vitro migration and proliferation of human osteoblasts in injectable in situ crosslinkable poly(caprolactone fumarate) scaffolds. AIChE Annual Meeting, Conference Proceedings. 2004. pp. 1129-1131
@inproceedings{66347254fb924845a78a9c64f5805ebd,
title = "In vitro migration and proliferation of human osteoblasts in injectable in situ crosslinkable poly(caprolactone fumarate) scaffolds",
abstract = "The in vitro proliferation and migration of human osteoblasts in porous poly(caprolactone fumarate) (PCLF) scaffolds were investigated. PCLF was synthesized by condensation polymerization of PCL with fumaryl chloride in methylene chloride with triethylamine as the catalyst. Scaffolds were fabricated from the PCLF copolymer with salt as the porogen, and dimethyltoluidine (DMT) as the accelerator. NMR and FTIR were used to confirm the presence of the fumarate group in the PCLF macromers. The results from cell migration study with confocal microscopy show that PCLF, as an injectable and in-situ crosslinkable scaffold, supports osteoblast attachment, migration, and proliferation in vitro.",
author = "Esmaiel Jabbari and Hefferan, {Theresa E.} and Lichun Lu and Pedersen, {Larry G.} and Currier, {Bradford L.} and Yaszemski, {Michael J}",
year = "2004",
language = "English (US)",
pages = "1129--1131",
booktitle = "AIChE Annual Meeting, Conference Proceedings",

}

TY - GEN

T1 - In vitro migration and proliferation of human osteoblasts in injectable in situ crosslinkable poly(caprolactone fumarate) scaffolds

AU - Jabbari, Esmaiel

AU - Hefferan, Theresa E.

AU - Lu, Lichun

AU - Pedersen, Larry G.

AU - Currier, Bradford L.

AU - Yaszemski, Michael J

PY - 2004

Y1 - 2004

N2 - The in vitro proliferation and migration of human osteoblasts in porous poly(caprolactone fumarate) (PCLF) scaffolds were investigated. PCLF was synthesized by condensation polymerization of PCL with fumaryl chloride in methylene chloride with triethylamine as the catalyst. Scaffolds were fabricated from the PCLF copolymer with salt as the porogen, and dimethyltoluidine (DMT) as the accelerator. NMR and FTIR were used to confirm the presence of the fumarate group in the PCLF macromers. The results from cell migration study with confocal microscopy show that PCLF, as an injectable and in-situ crosslinkable scaffold, supports osteoblast attachment, migration, and proliferation in vitro.

AB - The in vitro proliferation and migration of human osteoblasts in porous poly(caprolactone fumarate) (PCLF) scaffolds were investigated. PCLF was synthesized by condensation polymerization of PCL with fumaryl chloride in methylene chloride with triethylamine as the catalyst. Scaffolds were fabricated from the PCLF copolymer with salt as the porogen, and dimethyltoluidine (DMT) as the accelerator. NMR and FTIR were used to confirm the presence of the fumarate group in the PCLF macromers. The results from cell migration study with confocal microscopy show that PCLF, as an injectable and in-situ crosslinkable scaffold, supports osteoblast attachment, migration, and proliferation in vitro.

UR - http://www.scopus.com/inward/record.url?scp=22544440003&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=22544440003&partnerID=8YFLogxK

M3 - Conference contribution

AN - SCOPUS:22544440003

SP - 1129

EP - 1131

BT - AIChE Annual Meeting, Conference Proceedings

ER -