In vitro migration and proliferation of human osteoblasts in injectable in situ crosslinkable poly(caprolactone fumarate) scaffolds

Esmaiel Jabbari; Theresa E. Hefferan; Lichun Lu; Larry G. Pedersen; Bradford L. Currier; Michael J. Yaszemski

In vitro migration and proliferation of human osteoblasts in injectable in situ crosslinkable poly(caprolactone fumarate) scaffolds

Esmaiel Jabbari, Theresa E. Hefferan, Lichun Lu, Larry G. Pedersen, Bradford L. Currier, Michael J. Yaszemski

Orthopedic Surgery

Research output: Contribution to conference › Paper › peer-review

Abstract

The in vitro proliferation and migration of human osteoblasts in porous poly(caprolactone fumarate) (PCLF) scaffolds were investigated. PCLF was synthesized by condensation polymerization of PCL with fumaryl chloride in methylene chloride with triethylamine as the catalyst. Scaffolds were fabricated from the PCLF copolymer with salt as the porogen, and dimethyltoluidine (DMT) as the accelerator. NMR and FTIR were used to confirm the presence of the fumarate group in the PCLF macromers. The results from cell migration study with confocal microscopy show that PCLF, as an injectable and in-situ crosslinkable scaffold, supports osteoblast attachment, migration, and proliferation in vitro.

Original language	English (US)
Pages	1129-1131
Number of pages	3
State	Published - 2004
Event	2004 AIChE Annual Meeting - Austin, TX, United States Duration: Nov 7 2004 → Nov 12 2004

Other

Other	2004 AIChE Annual Meeting
Country/Territory	United States
City	Austin, TX
Period	11/7/04 → 11/12/04

ASJC Scopus subject areas

General Engineering

Cite this

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title = "In vitro migration and proliferation of human osteoblasts in injectable in situ crosslinkable poly(caprolactone fumarate) scaffolds",

abstract = "The in vitro proliferation and migration of human osteoblasts in porous poly(caprolactone fumarate) (PCLF) scaffolds were investigated. PCLF was synthesized by condensation polymerization of PCL with fumaryl chloride in methylene chloride with triethylamine as the catalyst. Scaffolds were fabricated from the PCLF copolymer with salt as the porogen, and dimethyltoluidine (DMT) as the accelerator. NMR and FTIR were used to confirm the presence of the fumarate group in the PCLF macromers. The results from cell migration study with confocal microscopy show that PCLF, as an injectable and in-situ crosslinkable scaffold, supports osteoblast attachment, migration, and proliferation in vitro.",

author = "Esmaiel Jabbari and Hefferan, {Theresa E.} and Lichun Lu and Pedersen, {Larry G.} and Currier, {Bradford L.} and Yaszemski, {Michael J.}",

year = "2004",

language = "English (US)",

pages = "1129--1131",

note = "2004 AIChE Annual Meeting ; Conference date: 07-11-2004 Through 12-11-2004",

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TY - CONF

T1 - In vitro migration and proliferation of human osteoblasts in injectable in situ crosslinkable poly(caprolactone fumarate) scaffolds

AU - Jabbari, Esmaiel

AU - Hefferan, Theresa E.

AU - Lu, Lichun

AU - Pedersen, Larry G.

AU - Currier, Bradford L.

AU - Yaszemski, Michael J.

PY - 2004

Y1 - 2004

N2 - The in vitro proliferation and migration of human osteoblasts in porous poly(caprolactone fumarate) (PCLF) scaffolds were investigated. PCLF was synthesized by condensation polymerization of PCL with fumaryl chloride in methylene chloride with triethylamine as the catalyst. Scaffolds were fabricated from the PCLF copolymer with salt as the porogen, and dimethyltoluidine (DMT) as the accelerator. NMR and FTIR were used to confirm the presence of the fumarate group in the PCLF macromers. The results from cell migration study with confocal microscopy show that PCLF, as an injectable and in-situ crosslinkable scaffold, supports osteoblast attachment, migration, and proliferation in vitro.

AB - The in vitro proliferation and migration of human osteoblasts in porous poly(caprolactone fumarate) (PCLF) scaffolds were investigated. PCLF was synthesized by condensation polymerization of PCL with fumaryl chloride in methylene chloride with triethylamine as the catalyst. Scaffolds were fabricated from the PCLF copolymer with salt as the porogen, and dimethyltoluidine (DMT) as the accelerator. NMR and FTIR were used to confirm the presence of the fumarate group in the PCLF macromers. The results from cell migration study with confocal microscopy show that PCLF, as an injectable and in-situ crosslinkable scaffold, supports osteoblast attachment, migration, and proliferation in vitro.

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UR - http://www.scopus.com/inward/citedby.url?scp=22544440003&partnerID=8YFLogxK

M3 - Paper

AN - SCOPUS:22544440003

SP - 1129

EP - 1131

T2 - 2004 AIChE Annual Meeting

Y2 - 7 November 2004 through 12 November 2004

ER -

In vitro migration and proliferation of human osteoblasts in injectable in situ crosslinkable poly(caprolactone fumarate) scaffolds

Abstract

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ASJC Scopus subject areas

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