In vitro migration and proliferation of human osteoblasts in injectable in situ crosslinkable poly(caprolactone fumarate) scaffolds

Esmaiel Jabbari, Theresa E. Hefferan, Lichun Lu, Larry G. Pedersen, Bradford L. Currier, Michael J. Yaszemski

Research output: Contribution to conferencePaper

Abstract

The in vitro proliferation and migration of human osteoblasts in porous poly(caprolactone fumarate) (PCLF) scaffolds were investigated. PCLF was synthesized by condensation polymerization of PCL with fumaryl chloride in methylene chloride with triethylamine as the catalyst. Scaffolds were fabricated from the PCLF copolymer with salt as the porogen, and dimethyltoluidine (DMT) as the accelerator. NMR and FTIR were used to confirm the presence of the fumarate group in the PCLF macromers. The results from cell migration study with confocal microscopy show that PCLF, as an injectable and in-situ crosslinkable scaffold, supports osteoblast attachment, migration, and proliferation in vitro.

Original languageEnglish (US)
Pages1129-1131
Number of pages3
StatePublished - Dec 1 2004
Event2004 AIChE Annual Meeting - Austin, TX, United States
Duration: Nov 7 2004Nov 12 2004

Other

Other2004 AIChE Annual Meeting
CountryUnited States
CityAustin, TX
Period11/7/0411/12/04

ASJC Scopus subject areas

  • Engineering(all)

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    Jabbari, E., Hefferan, T. E., Lu, L., Pedersen, L. G., Currier, B. L., & Yaszemski, M. J. (2004). In vitro migration and proliferation of human osteoblasts in injectable in situ crosslinkable poly(caprolactone fumarate) scaffolds. 1129-1131. Paper presented at 2004 AIChE Annual Meeting, Austin, TX, United States.