In vitro infection of smooth muscle cells by Chlamydia pneumoniae

Erin Knoebel, Parakat Vijayagopal, Julio E. Figueroa, David H. Martin

Research output: Contribution to journalArticlepeer-review

39 Scopus citations

Abstract

Recent observations have shown that both Chlamydia pneumoniae antigens and DNA may be found within atherosclerotic lesions. In this study, we evaluated the ability of C. pneumoniae to infect cells that make up atherosclerotic lesions, including endothelial cells, smooth muscle cells, and cholesterol-loaded smooth muscle cells. The organism readily infected rabbit, bovine, and human aortic smooth muscle cells. Cholesterol-loaded smooth muscle cells were even more susceptible to C. pneumoniae infection. Chlamydia trachomatis inefficiently infected smooth muscle cells, demonstrating that this is not a characteristic of all members of the genus Chlamydia, C. pneumoniae infected bovine endothelial cells poorly. This study demonstrates that C. pneumoniae readily infects one of the important types of cells found within atherosclerotic lesions, i.e., smooth muscle cells with and without cholesterol loading.

Original languageEnglish (US)
Pages (from-to)503-506
Number of pages4
JournalInfection and Immunity
Volume65
Issue number2
DOIs
StatePublished - Feb 1997

ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Immunology
  • Infectious Diseases

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