In vitro activity of tedizolid against staphylococci isolated from prosthetic joint infections

Suzannah M. Schmidt-Malan; Kerryl E. Greenwood Quaintance; Melissa J. Karau; Robin Patel

doi:10.1016/j.diagmicrobio.2016.01.008

In vitro activity of tedizolid against staphylococci isolated from prosthetic joint infections

Suzannah M. Schmidt-Malan, Kerryl E. Greenwood Quaintance, Melissa J. Karau, Robin Patel

Laboratory Medicine and Pathology

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

We determined the MIC and minimum biofilm bactericidal concentration (MBBC) of tedizolid and vancomycin against 97 isolates of Staphylococcus aureus and 74 isolates of Staphylococcus epidermidis associated with prosthetic joint infection. All isolates were vancomycin susceptible in the planktonic state; all staphylococci studied had a tedizolid MIC ≤0.5 μg/mL. The MBBC₉₀ was >32 and >128 μg/mL for tedizolid and vancomycin, respectively.

Original language	English (US)
Pages (from-to)	77-79
Number of pages	3
Journal	Diagnostic Microbiology and Infectious Disease
Volume	85
Issue number	1
DOIs	https://doi.org/10.1016/j.diagmicrobio.2016.01.008
State	Published - May 1 2016

Keywords

Biofilm
Staph aureus
Tedizolid

ASJC Scopus subject areas

Microbiology (medical)
Infectious Diseases

Access to Document

10.1016/j.diagmicrobio.2016.01.008

Cite this

@article{54c02f77877b4201aaa8d4facc915de6,

title = "In vitro activity of tedizolid against staphylococci isolated from prosthetic joint infections",

abstract = "We determined the MIC and minimum biofilm bactericidal concentration (MBBC) of tedizolid and vancomycin against 97 isolates of Staphylococcus aureus and 74 isolates of Staphylococcus epidermidis associated with prosthetic joint infection. All isolates were vancomycin susceptible in the planktonic state; all staphylococci studied had a tedizolid MIC ≤0.5 μg/mL. The MBBC90 was >32 and >128 μg/mL for tedizolid and vancomycin, respectively.",

keywords = "Biofilm, Staph aureus, Tedizolid",

author = "Schmidt-Malan, {Suzannah M.} and {Greenwood Quaintance}, {Kerryl E.} and Karau, {Melissa J.} and Robin Patel",

note = "Publisher Copyright: {\textcopyright} 2016 Elsevier Inc.",

year = "2016",

month = may,

day = "1",

doi = "10.1016/j.diagmicrobio.2016.01.008",

language = "English (US)",

volume = "85",

pages = "77--79",

journal = "Diagnostic Microbiology and Infectious Disease",

issn = "0732-8893",

publisher = "Elsevier Inc.",

number = "1",

}

TY - JOUR

T1 - In vitro activity of tedizolid against staphylococci isolated from prosthetic joint infections

AU - Schmidt-Malan, Suzannah M.

AU - Greenwood Quaintance, Kerryl E.

AU - Karau, Melissa J.

AU - Patel, Robin

PY - 2016/5/1

Y1 - 2016/5/1

N2 - We determined the MIC and minimum biofilm bactericidal concentration (MBBC) of tedizolid and vancomycin against 97 isolates of Staphylococcus aureus and 74 isolates of Staphylococcus epidermidis associated with prosthetic joint infection. All isolates were vancomycin susceptible in the planktonic state; all staphylococci studied had a tedizolid MIC ≤0.5 μg/mL. The MBBC90 was >32 and >128 μg/mL for tedizolid and vancomycin, respectively.

AB - We determined the MIC and minimum biofilm bactericidal concentration (MBBC) of tedizolid and vancomycin against 97 isolates of Staphylococcus aureus and 74 isolates of Staphylococcus epidermidis associated with prosthetic joint infection. All isolates were vancomycin susceptible in the planktonic state; all staphylococci studied had a tedizolid MIC ≤0.5 μg/mL. The MBBC90 was >32 and >128 μg/mL for tedizolid and vancomycin, respectively.

KW - Biofilm

KW - Staph aureus

KW - Tedizolid

UR - http://www.scopus.com/inward/record.url?scp=84959043962&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84959043962&partnerID=8YFLogxK

U2 - 10.1016/j.diagmicrobio.2016.01.008

DO - 10.1016/j.diagmicrobio.2016.01.008

M3 - Article

C2 - 26906190

AN - SCOPUS:84959043962

SN - 0732-8893

VL - 85

SP - 77

EP - 79

JO - Diagnostic Microbiology and Infectious Disease

JF - Diagnostic Microbiology and Infectious Disease

IS - 1

ER -

In vitro activity of tedizolid against staphylococci isolated from prosthetic joint infections

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this