In vitro activity of tedizolid against staphylococci isolated from prosthetic joint infections

Suzannah M. Schmidt-Malan, Kerryl E. Greenwood Quaintance, Melissa J. Karau, Robin Patel

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

We determined the MIC and minimum biofilm bactericidal concentration (MBBC) of tedizolid and vancomycin against 97 isolates of Staphylococcus aureus and 74 isolates of Staphylococcus epidermidis associated with prosthetic joint infection. All isolates were vancomycin susceptible in the planktonic state; all staphylococci studied had a tedizolid MIC ≤0.5 μg/mL. The MBBC90 was >32 and >128 μg/mL for tedizolid and vancomycin, respectively.

Original languageEnglish (US)
JournalDiagnostic Microbiology and Infectious Disease
DOIs
StateAccepted/In press - Nov 25 2015

Keywords

  • Biofilm
  • Staph aureus
  • Tedizolid

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

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