TY - JOUR
T1 - In-111-labeled leukocyte sctintigraphy in suspected orthopedic prosthesis infection
T2 - Comparison with other imaging modalities
AU - Magnuson, J. E.
AU - Brown, M. L.
AU - Hauser, M. F.
AU - Berquist, T. H.
AU - Fitzgerald, R. H.
AU - Klee, G. G.
PY - 1988
Y1 - 1988
N2 - When infection of prosthetic orthopedic implants is suspected, optimal management requires accurate confirmation or exclusion of infection. The authors retrospectively studied 98 patients with possible infection who underwent scanning with indium-111-labeled white blood cells (WBCs) and subsequent underwent surgery within 14 days. At surgery, 50 patients had infections, as determined by means of culture or histologic results. The diagnostic accuracy of In-111 scanning was compared with that of plain radiography, arthrography, three-phase bone scanning, and various clinical and laboratory findings classically associated with infection. Positive findings on In-111 WBC scans and elevated erythrocyte sedimentation rates were found to be the most predictive variables in the diagnosis of septic prostheses (P ≤ .001 and P ≤ .002, respectively). Likelihood ratio analysis more clearly demonstrated the superiority of In-111 WBC scanning, with positive and negative scans yielding likelihood ratios of 5.0 and 0.16, respectively.
AB - When infection of prosthetic orthopedic implants is suspected, optimal management requires accurate confirmation or exclusion of infection. The authors retrospectively studied 98 patients with possible infection who underwent scanning with indium-111-labeled white blood cells (WBCs) and subsequent underwent surgery within 14 days. At surgery, 50 patients had infections, as determined by means of culture or histologic results. The diagnostic accuracy of In-111 scanning was compared with that of plain radiography, arthrography, three-phase bone scanning, and various clinical and laboratory findings classically associated with infection. Positive findings on In-111 WBC scans and elevated erythrocyte sedimentation rates were found to be the most predictive variables in the diagnosis of septic prostheses (P ≤ .001 and P ≤ .002, respectively). Likelihood ratio analysis more clearly demonstrated the superiority of In-111 WBC scanning, with positive and negative scans yielding likelihood ratios of 5.0 and 0.16, respectively.
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U2 - 10.1148/radiology.168.1.3380966
DO - 10.1148/radiology.168.1.3380966
M3 - Article
C2 - 3380966
AN - SCOPUS:0023916313
SN - 0033-8419
VL - 168
SP - 235
EP - 239
JO - Radiology
JF - Radiology
IS - 1
ER -