In-111-labeled leukocyte sctintigraphy in suspected orthopedic prosthesis infection: Comparison with other imaging modalities

J. E. Magnuson, M. L. Brown, M. F. Hauser, T. H. Berquist, R. H. Fitzgerald, G. G. Klee

Research output: Contribution to journalArticle

94 Citations (Scopus)

Abstract

When infection of prosthetic orthopedic implants is suspected, optimal management requires accurate confirmation or exclusion of infection. The authors retrospectively studied 98 patients with possible infection who underwent scanning with indium-111-labeled white blood cells (WBCs) and subsequent underwent surgery within 14 days. At surgery, 50 patients had infections, as determined by means of culture or histologic results. The diagnostic accuracy of In-111 scanning was compared with that of plain radiography, arthrography, three-phase bone scanning, and various clinical and laboratory findings classically associated with infection. Positive findings on In-111 WBC scans and elevated erythrocyte sedimentation rates were found to be the most predictive variables in the diagnosis of septic prostheses (P ≤ .001 and P ≤ .002, respectively). Likelihood ratio analysis more clearly demonstrated the superiority of In-111 WBC scanning, with positive and negative scans yielding likelihood ratios of 5.0 and 0.16, respectively.

Original languageEnglish (US)
Pages (from-to)235-239
Number of pages5
JournalRadiology
Volume168
Issue number1
StatePublished - 1988

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Prostheses and Implants
Orthopedics
Leukocytes
Infection
Arthrography
Indium
Blood Sedimentation
Radiography
Bone and Bones

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology

Cite this

Magnuson, J. E., Brown, M. L., Hauser, M. F., Berquist, T. H., Fitzgerald, R. H., & Klee, G. G. (1988). In-111-labeled leukocyte sctintigraphy in suspected orthopedic prosthesis infection: Comparison with other imaging modalities. Radiology, 168(1), 235-239.

In-111-labeled leukocyte sctintigraphy in suspected orthopedic prosthesis infection : Comparison with other imaging modalities. / Magnuson, J. E.; Brown, M. L.; Hauser, M. F.; Berquist, T. H.; Fitzgerald, R. H.; Klee, G. G.

In: Radiology, Vol. 168, No. 1, 1988, p. 235-239.

Research output: Contribution to journalArticle

Magnuson, JE, Brown, ML, Hauser, MF, Berquist, TH, Fitzgerald, RH & Klee, GG 1988, 'In-111-labeled leukocyte sctintigraphy in suspected orthopedic prosthesis infection: Comparison with other imaging modalities', Radiology, vol. 168, no. 1, pp. 235-239.
Magnuson JE, Brown ML, Hauser MF, Berquist TH, Fitzgerald RH, Klee GG. In-111-labeled leukocyte sctintigraphy in suspected orthopedic prosthesis infection: Comparison with other imaging modalities. Radiology. 1988;168(1):235-239.
Magnuson, J. E. ; Brown, M. L. ; Hauser, M. F. ; Berquist, T. H. ; Fitzgerald, R. H. ; Klee, G. G. / In-111-labeled leukocyte sctintigraphy in suspected orthopedic prosthesis infection : Comparison with other imaging modalities. In: Radiology. 1988 ; Vol. 168, No. 1. pp. 235-239.
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