Improved scoring system to assess adult donors for cadaver renal transplantation

Scott Nyberg, Arthur J. Matas, Walter K Kremers, Jeffrey D. Thostenson, Timothy S. Larson, Mikel Prieto, Michael B. Ishitani, Sylvester Sterioff, Mark D Stegall

Research output: Contribution to journalArticle

137 Citations (Scopus)

Abstract

We previously proposed a quantitative approach to assess donor organs for cadaver renal transplantation. To improve on our original scoring system, we studied 34324 patients who received cadaver renal transplants from adult donors between 1994 and 1999 and were reported to the UNOS Scientific Renal Transplant Registry. A scoring system was developed from five donor variables (age, 0-25 points; history of hypertension, 0-4; creatinine clearance before procurement, 0-4; cause of death, 0-3; HLA mismatch, 0-3) that showed a significant correlation with renal function and long-term graft survival. Cadaver kidneys were stratified by cumulative donor score: grade A, 0-9 points; grade B, 10-19; grade C, 20-29; and grade D, 30-39. The influence of donor score on renal function and graft survival was most severe above 20 points, designated 'marginal' kidneys. In summary, a donor scoring system developed from a large population database was useful in predicting outcome after cadaver renal transplantation. The improved system provides a quantitative approach to evaluation of marginal kidneys and may improve allocation of these organs in cadaver renal transplantation.

Original languageEnglish (US)
Pages (from-to)715-721
Number of pages7
JournalAmerican Journal of Transplantation
Volume3
Issue number6
DOIs
StatePublished - Jun 2003

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Cadaver
Kidney Transplantation
Tissue Donors
Kidney
Graft Survival
Transplants
Registries
Cause of Death
Creatinine
Databases
Hypertension
Population

Keywords

  • Graft survival
  • Marginal donor
  • Organ allocation
  • Renal function

ASJC Scopus subject areas

  • Immunology

Cite this

Improved scoring system to assess adult donors for cadaver renal transplantation. / Nyberg, Scott; Matas, Arthur J.; Kremers, Walter K; Thostenson, Jeffrey D.; Larson, Timothy S.; Prieto, Mikel; Ishitani, Michael B.; Sterioff, Sylvester; Stegall, Mark D.

In: American Journal of Transplantation, Vol. 3, No. 6, 06.2003, p. 715-721.

Research output: Contribution to journalArticle

Nyberg, Scott ; Matas, Arthur J. ; Kremers, Walter K ; Thostenson, Jeffrey D. ; Larson, Timothy S. ; Prieto, Mikel ; Ishitani, Michael B. ; Sterioff, Sylvester ; Stegall, Mark D. / Improved scoring system to assess adult donors for cadaver renal transplantation. In: American Journal of Transplantation. 2003 ; Vol. 3, No. 6. pp. 715-721.
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