TY - JOUR
T1 - Improved assessment of control in intermittent exotropia using multiple measures
AU - Hatt, Sarah R.
AU - Liebermann, Laura
AU - Leske, David A.
AU - Mohney, Brian G.
AU - Holmes, Jonathan M.
N1 - Funding Information:
Publication of this article was supported by National Institutes of Health , Bethesda, Maryland (Grants EY015799 and EY018810 [J.M.H.]); Research to Prevent Blindness, New York, New York (J.M.H. as Olga Keith Weiss Scholar and an unrestricted grant to the Department of Ophthalmology, Mayo Clinic); and Mayo Foundation, Rochester, Minnesota. All authors have completed and submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest and none were reported. Involved in design and conduct of the study (S.R.H., L.L., D.A.L., B.G.M., J.M.H.); collection of data (S.R.H., L.L., J.M.H.); management, analysis, and interpretation of the data (S.R.H., D.A.L., L.L., J.M.H., B.G.M.); and preparation, review, and approval of the manuscript (S.R.H., D.A.L., L.L., B.G.M., J.M.H.). Institutional Review Board/Ethics Committee approval was obtained for this study from Mayo Clinic, Rochester, Minnesota. All experiments and data collection were conducted in a manner compliant with the Health Insurance Portability and Accountability Act. Informed consent was obtained from all participants and informed assent for participants aged 8 to 12 years old. All research procedures adhered to the tenets of the Declaration of Helsinki.
PY - 2011/11
Y1 - 2011/11
N2 - Purpose: To develop and validate an improved measure of control in intermittent exotropia (XT). Design: Prospective, noninterventional case series. Methods: Twelve children with intermittent XT were evaluated during 4 sessions (2 hours apart) over a day, on 2 separate days (8 sessions per child). Control was standardized using a scoring system and quantified 3 times during each examination. Overall control for a day was calculated as the mean of all 12 measures. Single measures of control and the mean of 2 (double) and 3 (triple) measures over the examination were compared with the respective day mean, and first-day measures were compared to the second-day mean. Results: At distance, 17% (49/287, 95% confidence interval [CI] 13% to 22%) of single measures differed from the day mean, whereas only 8% (16/191, 95 CI 5% to 13%) of double measures and 5% (5/95, 95% CI 2% to 12%) of triple measures differed. Comparing day 1 measures to overall mean for day 2, 17% (24/143, 95% CI 11% to 24%) of single measures and 17% (22/130, 95% CI 11% to 24%) of double measures differed by more than 1 level, whereas 11% (5/47, 95% CI 4% to 23%) of triple measures differed. Conclusions: The mean of 3 assessments of control during a clinic examination better represents overall control than a single measure.
AB - Purpose: To develop and validate an improved measure of control in intermittent exotropia (XT). Design: Prospective, noninterventional case series. Methods: Twelve children with intermittent XT were evaluated during 4 sessions (2 hours apart) over a day, on 2 separate days (8 sessions per child). Control was standardized using a scoring system and quantified 3 times during each examination. Overall control for a day was calculated as the mean of all 12 measures. Single measures of control and the mean of 2 (double) and 3 (triple) measures over the examination were compared with the respective day mean, and first-day measures were compared to the second-day mean. Results: At distance, 17% (49/287, 95% confidence interval [CI] 13% to 22%) of single measures differed from the day mean, whereas only 8% (16/191, 95 CI 5% to 13%) of double measures and 5% (5/95, 95% CI 2% to 12%) of triple measures differed. Comparing day 1 measures to overall mean for day 2, 17% (24/143, 95% CI 11% to 24%) of single measures and 17% (22/130, 95% CI 11% to 24%) of double measures differed by more than 1 level, whereas 11% (5/47, 95% CI 4% to 23%) of triple measures differed. Conclusions: The mean of 3 assessments of control during a clinic examination better represents overall control than a single measure.
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U2 - 10.1016/j.ajo.2011.05.007
DO - 10.1016/j.ajo.2011.05.007
M3 - Article
C2 - 21843874
AN - SCOPUS:80054986463
SN - 0002-9394
VL - 152
SP - 872
EP - 876
JO - American journal of ophthalmology
JF - American journal of ophthalmology
IS - 5
ER -