Impaired autophagy in motor neurons: A final common mechanism of injury and death

Maria A.Gonzalez Porras, Gary C. Sieck, Carlos B. Mantilla

Research output: Contribution to journalReview article

4 Scopus citations

Abstract

Autophagy is a cellular digestion process that contributes to cellular homeostasis and adaptation by the elimination of proteins and damaged organelles. Evidence suggests that dysregulation of autophagy plays a role in neurodegenerative diseases, including motor neuron disorders. Herein, we review emerging evidence indicating the roles of autophagy in physiological motor neuron processes and its function in specific compartments. Moreover, we discuss the involvement of autophagy in the pathogenesis of motor neuron diseases, including spinal cord injury and aging, and recent developments that offer promising therapeutic approaches to mitigate effects of dysregulated autophagy in health and disease.

Original languageEnglish (US)
Pages (from-to)211-224
Number of pages14
JournalPhysiology
Volume33
Issue number3
DOIs
StatePublished - May 2018

ASJC Scopus subject areas

  • Physiology

Fingerprint Dive into the research topics of 'Impaired autophagy in motor neurons: A final common mechanism of injury and death'. Together they form a unique fingerprint.

  • Cite this