Impaired autophagy in motor neurons

A final common mechanism of injury and death

Maria A.Gonzalez Porras, Gary C Sieck, Carlos Bernardo Mantilla

Research output: Contribution to journalReview article

3 Citations (Scopus)

Abstract

Autophagy is a cellular digestion process that contributes to cellular homeostasis and adaptation by the elimination of proteins and damaged organelles. Evidence suggests that dysregulation of autophagy plays a role in neurodegenerative diseases, including motor neuron disorders. Herein, we review emerging evidence indicating the roles of autophagy in physiological motor neuron processes and its function in specific compartments. Moreover, we discuss the involvement of autophagy in the pathogenesis of motor neuron diseases, including spinal cord injury and aging, and recent developments that offer promising therapeutic approaches to mitigate effects of dysregulated autophagy in health and disease.

Original languageEnglish (US)
Pages (from-to)211-224
Number of pages14
JournalPhysiology
Volume33
Issue number3
DOIs
StatePublished - May 1 2018

Fingerprint

Autophagy
Motor Neurons
Wounds and Injuries
Motor Neuron Disease
Spinal Cord Injuries
Neurodegenerative Diseases
Organelles
Digestion
Homeostasis
Health
Proteins

ASJC Scopus subject areas

  • Physiology

Cite this

Impaired autophagy in motor neurons : A final common mechanism of injury and death. / Porras, Maria A.Gonzalez; Sieck, Gary C; Mantilla, Carlos Bernardo.

In: Physiology, Vol. 33, No. 3, 01.05.2018, p. 211-224.

Research output: Contribution to journalReview article

Porras, Maria A.Gonzalez ; Sieck, Gary C ; Mantilla, Carlos Bernardo. / Impaired autophagy in motor neurons : A final common mechanism of injury and death. In: Physiology. 2018 ; Vol. 33, No. 3. pp. 211-224.
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