Impact of tricuspid valve regurgitation on intermediate outcomes of degenerative mitral valve surgery

Irsa S. Hasan, Mohammad Qrareya, Juan A. Crestanello, Richard C Daly, Joseph Dearani, Brian D. Lahr, Alex T. Lee, John M. Stulak, Kevin L. Greason, Hartzell V. Schaff

Research output: Contribution to journalArticlepeer-review


Background: In patients undergoing mitral valve surgery, optimal management of less-than-severe concomitant tricuspid valve regurgitation (TR) is unclear, as there are few long-term data. This study examines progression of TR, patient survival, and reoperations in patients undergoing mitral valve surgery. Methods: There were 1588 patients who underwent degenerative mitral valve surgery and had pre- and postoperative echocardiograms for assessment of TR severity and tricuspid annulus diameter. Analysis used repeated-measures ordinal regression to model the longitudinal trends in TR grade and proportional hazards regression for long-term survival and reoperation outcomes. Results: Concomitant tricuspid valve (TV) surgery was performed in 235 (14.8%) patients. In response to surgery, TR grades improved more in patients with concomitant TV intervention regardless of the severity of preoperative TR, and these early trends were sustained over long-term follow-up. Risk of progression to severe TR was not influenced by tricuspid annulus diameter (P =.226). After we adjusted for underlying health characteristics, survival following mitral valve surgery was similar in patients with and without TV intervention. Late TV reoperation was observed in 22 patients (5-year cumulative risk 1.5%), but among these, only 6 patients had severe TR as the primary indication for reoperation; preoperative TR grade and initial concomitant TV surgery were not associated with incidence of reoperation. Conclusions: Concomitant TV surgery for moderate TR reduces progression of TR but did not influence survival or incidence of reoperation. Among patients with less-than-severe preoperative TR, tricuspid annular diameter was not associated with progression to severe TR.

Original languageEnglish (US)
JournalJournal of Thoracic and Cardiovascular Surgery
StateAccepted/In press - 2022


  • degenerative mitral valve disease
  • echocardiography
  • mitral valve
  • tricuspid regurgitation
  • tricuspid valve

ASJC Scopus subject areas

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine


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