Impact of the Radiation Dose and Completion of Palliative Radiotherapy on Survival in Patients Treated for Locally Advanced Lung Cancer

Stefan Janssen, Lukas Kaesmann, Steven E. Schild, Dirk Rades

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

AIM: To compare three total radiation dose levels for their impact on survival in patients receiving palliative radiotherapy (RT) for locally advanced lung cancer.

PATIENTS AND METHODS: Radiation dose (equivalent dose in 2 Gy fractions=EQD2: 31-40 Gy vs. 41-46 Gy vs. 47-52 Gy), completion of RT as planned, plus nine factors were analyzed for survival in 125 patients.

RESULTS: On multivariate analysis, EQD2 47-52 Gy (p=0.018), completion of planned RT (p=0.002), lower T-category (p=0.027) and lower N-category (p=0.008) were positively associated with survival. Thirty-six patients (29%) could not receive the complete planned RT dose, 19% in the 31-40 Gy group, 36% in the 41-46 Gy group and 31% in the 47-52 Gy group, respectively. Six-month survival rates of these patients were 0%, 18% and 18%, respectively.

CONCLUSION: Higher RT doses resulted in significantly better survival than lower doses. The favorable results were impaired when the planned treatment could not be completed.

Original languageEnglish (US)
Pages (from-to)1825-1828
Number of pages4
JournalAnticancer Research
Volume36
Issue number4
StatePublished - Apr 1 2016

Keywords

  • Advanced lung cancer
  • completion of treatment
  • palliative radiation therapy
  • radiation dose
  • survival

ASJC Scopus subject areas

  • Medicine(all)
  • Oncology
  • Cancer Research

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