Impact of smoking on complication and pseudarthrosis rates after single- and 2-level posterolateral fusion of the lumbar spine

Mohamad Bydon, Rafael De La Garza-Ramos, Nicholas B. Abt, Ziya L. Gokaslan, Jean Paul Wolinsky, Daniel M. Sciubba, Ali Bydon, Timothy F. Witham

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

STUDY DESIGN.: Retrospective study. OBJECTIVE.: To study the impact of smoking status on postoperative complications and pseudarthrosis in adult patients undergoing posterolateral fusion (PLF) of the lumbar spine. SUMMARY OF BACKGROUND DATA.: Results of studies analyzing the impact of smoking on complication and pseudarthrosis rates after spine surgery are conflicting. METHODS.: A retrospective medical record review was performed to identify all adult patients who underwent single- and 2-level instrumented PLF without interbody devices for degenerative spine disease in a 21-year period at a single institution. Patients were divided into smokers and nonsmokers. The main outcome variables were development of at least one postoperative complication and development of pseudarthrosis. RESULTS.: A total of 281 patients underwent single- or 2-level PLF in the 21-year period. Of these, 231 (82.21%) patients were nonsmokers and 50 (17.9%) were smokers. For patients undergoing single-level PLF, complication rates in nonsmokers (3.57%) versus smokers (7.69%) were not significantly different (P = 0.353); pseudarthrosis in nonsmokers occurred in 9.82% of cases compared with 7.69% in the smokers group (P = 0.738). Nonsmokers undergoing 2-level PLF had complication rates of 6.72%, compared with 4.17% in smokers (P = 0.638), but pseudarthrosis rates were significantly higher in the smokers group than in the nonsmokers group (29.17% vs. 10.92%; P = 0.019). Patients were followed up for an average of 53.5 months. CONCLUSION.: The findings in this study suggest that smoking has a significant impact on pseudarthrosis rates after 2-level PLF of the lumbar spine, but not necessarily on single-level PLF.Level of Evidence: 4.

Original languageEnglish (US)
Pages (from-to)1765-1770
Number of pages6
JournalSpine
Volume39
Issue number21
DOIs
StatePublished - Oct 1 2014
Externally publishedYes

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Pseudarthrosis
Spine
Smoking
Medical Records
Retrospective Studies
Equipment and Supplies

Keywords

  • complications
  • fusion
  • lumbar
  • outcomes
  • posterolateral fusion
  • pseudarthrosis
  • smoking
  • spine
  • surgery

ASJC Scopus subject areas

  • Clinical Neurology
  • Orthopedics and Sports Medicine
  • Medicine(all)

Cite this

Bydon, M., De La Garza-Ramos, R., Abt, N. B., Gokaslan, Z. L., Wolinsky, J. P., Sciubba, D. M., ... Witham, T. F. (2014). Impact of smoking on complication and pseudarthrosis rates after single- and 2-level posterolateral fusion of the lumbar spine. Spine, 39(21), 1765-1770. https://doi.org/10.1097/BRS.0000000000000527

Impact of smoking on complication and pseudarthrosis rates after single- and 2-level posterolateral fusion of the lumbar spine. / Bydon, Mohamad; De La Garza-Ramos, Rafael; Abt, Nicholas B.; Gokaslan, Ziya L.; Wolinsky, Jean Paul; Sciubba, Daniel M.; Bydon, Ali; Witham, Timothy F.

In: Spine, Vol. 39, No. 21, 01.10.2014, p. 1765-1770.

Research output: Contribution to journalArticle

Bydon, M, De La Garza-Ramos, R, Abt, NB, Gokaslan, ZL, Wolinsky, JP, Sciubba, DM, Bydon, A & Witham, TF 2014, 'Impact of smoking on complication and pseudarthrosis rates after single- and 2-level posterolateral fusion of the lumbar spine', Spine, vol. 39, no. 21, pp. 1765-1770. https://doi.org/10.1097/BRS.0000000000000527
Bydon, Mohamad ; De La Garza-Ramos, Rafael ; Abt, Nicholas B. ; Gokaslan, Ziya L. ; Wolinsky, Jean Paul ; Sciubba, Daniel M. ; Bydon, Ali ; Witham, Timothy F. / Impact of smoking on complication and pseudarthrosis rates after single- and 2-level posterolateral fusion of the lumbar spine. In: Spine. 2014 ; Vol. 39, No. 21. pp. 1765-1770.
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abstract = "STUDY DESIGN.: Retrospective study. OBJECTIVE.: To study the impact of smoking status on postoperative complications and pseudarthrosis in adult patients undergoing posterolateral fusion (PLF) of the lumbar spine. SUMMARY OF BACKGROUND DATA.: Results of studies analyzing the impact of smoking on complication and pseudarthrosis rates after spine surgery are conflicting. METHODS.: A retrospective medical record review was performed to identify all adult patients who underwent single- and 2-level instrumented PLF without interbody devices for degenerative spine disease in a 21-year period at a single institution. Patients were divided into smokers and nonsmokers. The main outcome variables were development of at least one postoperative complication and development of pseudarthrosis. RESULTS.: A total of 281 patients underwent single- or 2-level PLF in the 21-year period. Of these, 231 (82.21{\%}) patients were nonsmokers and 50 (17.9{\%}) were smokers. For patients undergoing single-level PLF, complication rates in nonsmokers (3.57{\%}) versus smokers (7.69{\%}) were not significantly different (P = 0.353); pseudarthrosis in nonsmokers occurred in 9.82{\%} of cases compared with 7.69{\%} in the smokers group (P = 0.738). Nonsmokers undergoing 2-level PLF had complication rates of 6.72{\%}, compared with 4.17{\%} in smokers (P = 0.638), but pseudarthrosis rates were significantly higher in the smokers group than in the nonsmokers group (29.17{\%} vs. 10.92{\%}; P = 0.019). Patients were followed up for an average of 53.5 months. CONCLUSION.: The findings in this study suggest that smoking has a significant impact on pseudarthrosis rates after 2-level PLF of the lumbar spine, but not necessarily on single-level PLF.Level of Evidence: 4.",
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T1 - Impact of smoking on complication and pseudarthrosis rates after single- and 2-level posterolateral fusion of the lumbar spine

AU - Bydon, Mohamad

AU - De La Garza-Ramos, Rafael

AU - Abt, Nicholas B.

AU - Gokaslan, Ziya L.

AU - Wolinsky, Jean Paul

AU - Sciubba, Daniel M.

AU - Bydon, Ali

AU - Witham, Timothy F.

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N2 - STUDY DESIGN.: Retrospective study. OBJECTIVE.: To study the impact of smoking status on postoperative complications and pseudarthrosis in adult patients undergoing posterolateral fusion (PLF) of the lumbar spine. SUMMARY OF BACKGROUND DATA.: Results of studies analyzing the impact of smoking on complication and pseudarthrosis rates after spine surgery are conflicting. METHODS.: A retrospective medical record review was performed to identify all adult patients who underwent single- and 2-level instrumented PLF without interbody devices for degenerative spine disease in a 21-year period at a single institution. Patients were divided into smokers and nonsmokers. The main outcome variables were development of at least one postoperative complication and development of pseudarthrosis. RESULTS.: A total of 281 patients underwent single- or 2-level PLF in the 21-year period. Of these, 231 (82.21%) patients were nonsmokers and 50 (17.9%) were smokers. For patients undergoing single-level PLF, complication rates in nonsmokers (3.57%) versus smokers (7.69%) were not significantly different (P = 0.353); pseudarthrosis in nonsmokers occurred in 9.82% of cases compared with 7.69% in the smokers group (P = 0.738). Nonsmokers undergoing 2-level PLF had complication rates of 6.72%, compared with 4.17% in smokers (P = 0.638), but pseudarthrosis rates were significantly higher in the smokers group than in the nonsmokers group (29.17% vs. 10.92%; P = 0.019). Patients were followed up for an average of 53.5 months. CONCLUSION.: The findings in this study suggest that smoking has a significant impact on pseudarthrosis rates after 2-level PLF of the lumbar spine, but not necessarily on single-level PLF.Level of Evidence: 4.

AB - STUDY DESIGN.: Retrospective study. OBJECTIVE.: To study the impact of smoking status on postoperative complications and pseudarthrosis in adult patients undergoing posterolateral fusion (PLF) of the lumbar spine. SUMMARY OF BACKGROUND DATA.: Results of studies analyzing the impact of smoking on complication and pseudarthrosis rates after spine surgery are conflicting. METHODS.: A retrospective medical record review was performed to identify all adult patients who underwent single- and 2-level instrumented PLF without interbody devices for degenerative spine disease in a 21-year period at a single institution. Patients were divided into smokers and nonsmokers. The main outcome variables were development of at least one postoperative complication and development of pseudarthrosis. RESULTS.: A total of 281 patients underwent single- or 2-level PLF in the 21-year period. Of these, 231 (82.21%) patients were nonsmokers and 50 (17.9%) were smokers. For patients undergoing single-level PLF, complication rates in nonsmokers (3.57%) versus smokers (7.69%) were not significantly different (P = 0.353); pseudarthrosis in nonsmokers occurred in 9.82% of cases compared with 7.69% in the smokers group (P = 0.738). Nonsmokers undergoing 2-level PLF had complication rates of 6.72%, compared with 4.17% in smokers (P = 0.638), but pseudarthrosis rates were significantly higher in the smokers group than in the nonsmokers group (29.17% vs. 10.92%; P = 0.019). Patients were followed up for an average of 53.5 months. CONCLUSION.: The findings in this study suggest that smoking has a significant impact on pseudarthrosis rates after 2-level PLF of the lumbar spine, but not necessarily on single-level PLF.Level of Evidence: 4.

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KW - outcomes

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KW - pseudarthrosis

KW - smoking

KW - spine

KW - surgery

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