Impact of sentinel node status and other risk factors on the clinical outcome of head and neck melanoma patients

Stanley P L Leong, Neil A. Accortt, Richard Essner, Merrick Ross, Jeffrey E. Gershenwald, Barbara A Pockaj, Harald J. Hoekstra, Carlos Garberoglio, Richard L. White, David Chu, Merrill Biel, Kim Charney, Harold Wanebo, Eli Avisar, John Vetto, Seng Jaw Soong

Research output: Contribution to journalArticle

73 Citations (Scopus)

Abstract

Objective: To determine the impact of sentinel lymph node (SLN) status and other risk factorsonrecurrence and overall survival in head and neck melanoma patients. Design: The SLN Working Group, based in San Francisco, Calif, with its 11 member centers, the John Wayne Cancer Institute, and The University of Texas M. D. Anderson Cancer Center pooled data on 629 primary head and neck melanoma patients who had selective sentinel lymphadenectomy. A total of 614 subjects were analyzable. All centers obtained internal review board approval and adhered to the Health Insurance Portability and Accountability Act of 1996 regulations. A Cox proportional hazards model was used to identify factors associated with overall and disease-free survival. Setting: Tertiary care medical centers. Main Outcome Measure: Clinical outcome of head and neck melanoma patients undergoing selective sentinel lymphadenectomy. Results: Overall, 10.1% (n=62) of the subjects had at least 1 positive node. Subjects with positive SLN status had significantly thicker tumors (mean thickness, 2.8 vs 2.1 mm; P<.001), and were more likely to have ulcerated tumors (P=.004). During the median follow-up of 3.3 years, the overall mortality from head and neck melanoma was 10%, with more than20%experiencing at least 1 recurrence. Multivariate analysis showed that tumor site was an independent predictor of mortality; location on the scalp had a more than 3-fold (P<.001) greater mortality than tumors on the face. Tumor thickness was also an independent predictor of overall survival, and SLN status was the most important predictor of disease-free survival in the multivariate model (P<.001). Tumors on the scalp had the highest rate of recurrence, while those on the neck had the lowest. Tumor ulceration was the significant predictor of time to recurrence or disease-free survival (P<.001). Conclusion: In this multicenter study, SLN status and other risk factors have an effect on recurrence and/or overall survival.

Original languageEnglish (US)
Pages (from-to)370-373
Number of pages4
JournalArchives of Otolaryngology - Head and Neck Surgery
Volume132
Issue number4
DOIs
StatePublished - Apr 2006

Fingerprint

Melanoma
Neck
Head
Neoplasms
Disease-Free Survival
Recurrence
Lymph Node Excision
Scalp
Survival
Mortality
Health Insurance Portability and Accountability Act
cyhalothrin
San Francisco
Proportional Hazards Models
Tertiary Care Centers
Multicenter Studies
Multivariate Analysis
Outcome Assessment (Health Care)
Sentinel Lymph Node

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

Impact of sentinel node status and other risk factors on the clinical outcome of head and neck melanoma patients. / Leong, Stanley P L; Accortt, Neil A.; Essner, Richard; Ross, Merrick; Gershenwald, Jeffrey E.; Pockaj, Barbara A; Hoekstra, Harald J.; Garberoglio, Carlos; White, Richard L.; Chu, David; Biel, Merrill; Charney, Kim; Wanebo, Harold; Avisar, Eli; Vetto, John; Soong, Seng Jaw.

In: Archives of Otolaryngology - Head and Neck Surgery, Vol. 132, No. 4, 04.2006, p. 370-373.

Research output: Contribution to journalArticle

Leong, SPL, Accortt, NA, Essner, R, Ross, M, Gershenwald, JE, Pockaj, BA, Hoekstra, HJ, Garberoglio, C, White, RL, Chu, D, Biel, M, Charney, K, Wanebo, H, Avisar, E, Vetto, J & Soong, SJ 2006, 'Impact of sentinel node status and other risk factors on the clinical outcome of head and neck melanoma patients', Archives of Otolaryngology - Head and Neck Surgery, vol. 132, no. 4, pp. 370-373. https://doi.org/10.1001/archotol.132.4.370
Leong, Stanley P L ; Accortt, Neil A. ; Essner, Richard ; Ross, Merrick ; Gershenwald, Jeffrey E. ; Pockaj, Barbara A ; Hoekstra, Harald J. ; Garberoglio, Carlos ; White, Richard L. ; Chu, David ; Biel, Merrill ; Charney, Kim ; Wanebo, Harold ; Avisar, Eli ; Vetto, John ; Soong, Seng Jaw. / Impact of sentinel node status and other risk factors on the clinical outcome of head and neck melanoma patients. In: Archives of Otolaryngology - Head and Neck Surgery. 2006 ; Vol. 132, No. 4. pp. 370-373.
@article{9395ceafac7f4cccaa2dcfdb95c5c5ee,
title = "Impact of sentinel node status and other risk factors on the clinical outcome of head and neck melanoma patients",
abstract = "Objective: To determine the impact of sentinel lymph node (SLN) status and other risk factorsonrecurrence and overall survival in head and neck melanoma patients. Design: The SLN Working Group, based in San Francisco, Calif, with its 11 member centers, the John Wayne Cancer Institute, and The University of Texas M. D. Anderson Cancer Center pooled data on 629 primary head and neck melanoma patients who had selective sentinel lymphadenectomy. A total of 614 subjects were analyzable. All centers obtained internal review board approval and adhered to the Health Insurance Portability and Accountability Act of 1996 regulations. A Cox proportional hazards model was used to identify factors associated with overall and disease-free survival. Setting: Tertiary care medical centers. Main Outcome Measure: Clinical outcome of head and neck melanoma patients undergoing selective sentinel lymphadenectomy. Results: Overall, 10.1{\%} (n=62) of the subjects had at least 1 positive node. Subjects with positive SLN status had significantly thicker tumors (mean thickness, 2.8 vs 2.1 mm; P<.001), and were more likely to have ulcerated tumors (P=.004). During the median follow-up of 3.3 years, the overall mortality from head and neck melanoma was 10{\%}, with more than20{\%}experiencing at least 1 recurrence. Multivariate analysis showed that tumor site was an independent predictor of mortality; location on the scalp had a more than 3-fold (P<.001) greater mortality than tumors on the face. Tumor thickness was also an independent predictor of overall survival, and SLN status was the most important predictor of disease-free survival in the multivariate model (P<.001). Tumors on the scalp had the highest rate of recurrence, while those on the neck had the lowest. Tumor ulceration was the significant predictor of time to recurrence or disease-free survival (P<.001). Conclusion: In this multicenter study, SLN status and other risk factors have an effect on recurrence and/or overall survival.",
author = "Leong, {Stanley P L} and Accortt, {Neil A.} and Richard Essner and Merrick Ross and Gershenwald, {Jeffrey E.} and Pockaj, {Barbara A} and Hoekstra, {Harald J.} and Carlos Garberoglio and White, {Richard L.} and David Chu and Merrill Biel and Kim Charney and Harold Wanebo and Eli Avisar and John Vetto and Soong, {Seng Jaw}",
year = "2006",
month = "4",
doi = "10.1001/archotol.132.4.370",
language = "English (US)",
volume = "132",
pages = "370--373",
journal = "JAMA Otolaryngology - Head and Neck Surgery",
issn = "2168-6181",
publisher = "American Medical Association",
number = "4",

}

TY - JOUR

T1 - Impact of sentinel node status and other risk factors on the clinical outcome of head and neck melanoma patients

AU - Leong, Stanley P L

AU - Accortt, Neil A.

AU - Essner, Richard

AU - Ross, Merrick

AU - Gershenwald, Jeffrey E.

AU - Pockaj, Barbara A

AU - Hoekstra, Harald J.

AU - Garberoglio, Carlos

AU - White, Richard L.

AU - Chu, David

AU - Biel, Merrill

AU - Charney, Kim

AU - Wanebo, Harold

AU - Avisar, Eli

AU - Vetto, John

AU - Soong, Seng Jaw

PY - 2006/4

Y1 - 2006/4

N2 - Objective: To determine the impact of sentinel lymph node (SLN) status and other risk factorsonrecurrence and overall survival in head and neck melanoma patients. Design: The SLN Working Group, based in San Francisco, Calif, with its 11 member centers, the John Wayne Cancer Institute, and The University of Texas M. D. Anderson Cancer Center pooled data on 629 primary head and neck melanoma patients who had selective sentinel lymphadenectomy. A total of 614 subjects were analyzable. All centers obtained internal review board approval and adhered to the Health Insurance Portability and Accountability Act of 1996 regulations. A Cox proportional hazards model was used to identify factors associated with overall and disease-free survival. Setting: Tertiary care medical centers. Main Outcome Measure: Clinical outcome of head and neck melanoma patients undergoing selective sentinel lymphadenectomy. Results: Overall, 10.1% (n=62) of the subjects had at least 1 positive node. Subjects with positive SLN status had significantly thicker tumors (mean thickness, 2.8 vs 2.1 mm; P<.001), and were more likely to have ulcerated tumors (P=.004). During the median follow-up of 3.3 years, the overall mortality from head and neck melanoma was 10%, with more than20%experiencing at least 1 recurrence. Multivariate analysis showed that tumor site was an independent predictor of mortality; location on the scalp had a more than 3-fold (P<.001) greater mortality than tumors on the face. Tumor thickness was also an independent predictor of overall survival, and SLN status was the most important predictor of disease-free survival in the multivariate model (P<.001). Tumors on the scalp had the highest rate of recurrence, while those on the neck had the lowest. Tumor ulceration was the significant predictor of time to recurrence or disease-free survival (P<.001). Conclusion: In this multicenter study, SLN status and other risk factors have an effect on recurrence and/or overall survival.

AB - Objective: To determine the impact of sentinel lymph node (SLN) status and other risk factorsonrecurrence and overall survival in head and neck melanoma patients. Design: The SLN Working Group, based in San Francisco, Calif, with its 11 member centers, the John Wayne Cancer Institute, and The University of Texas M. D. Anderson Cancer Center pooled data on 629 primary head and neck melanoma patients who had selective sentinel lymphadenectomy. A total of 614 subjects were analyzable. All centers obtained internal review board approval and adhered to the Health Insurance Portability and Accountability Act of 1996 regulations. A Cox proportional hazards model was used to identify factors associated with overall and disease-free survival. Setting: Tertiary care medical centers. Main Outcome Measure: Clinical outcome of head and neck melanoma patients undergoing selective sentinel lymphadenectomy. Results: Overall, 10.1% (n=62) of the subjects had at least 1 positive node. Subjects with positive SLN status had significantly thicker tumors (mean thickness, 2.8 vs 2.1 mm; P<.001), and were more likely to have ulcerated tumors (P=.004). During the median follow-up of 3.3 years, the overall mortality from head and neck melanoma was 10%, with more than20%experiencing at least 1 recurrence. Multivariate analysis showed that tumor site was an independent predictor of mortality; location on the scalp had a more than 3-fold (P<.001) greater mortality than tumors on the face. Tumor thickness was also an independent predictor of overall survival, and SLN status was the most important predictor of disease-free survival in the multivariate model (P<.001). Tumors on the scalp had the highest rate of recurrence, while those on the neck had the lowest. Tumor ulceration was the significant predictor of time to recurrence or disease-free survival (P<.001). Conclusion: In this multicenter study, SLN status and other risk factors have an effect on recurrence and/or overall survival.

UR - http://www.scopus.com/inward/record.url?scp=33645839864&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33645839864&partnerID=8YFLogxK

U2 - 10.1001/archotol.132.4.370

DO - 10.1001/archotol.132.4.370

M3 - Article

VL - 132

SP - 370

EP - 373

JO - JAMA Otolaryngology - Head and Neck Surgery

JF - JAMA Otolaryngology - Head and Neck Surgery

SN - 2168-6181

IS - 4

ER -