TY - JOUR
T1 - Impact of Senescent Cell Subtypes on Tissue Dysfunction and Repair
T2 - Importance and Research Questions
AU - Tripathi, Utkarsh
AU - Misra, Avanish
AU - Tchkonia, Tamar
AU - Kirkland, James L.
N1 - Publisher Copyright:
© 2021 The Authors
PY - 2021/9
Y1 - 2021/9
N2 - Cellular senescence, first observed and defined through cell culture studies, is a cell fate associated with essentially permanent cell cycle arrest and that can be triggered by a variety of inducers. Emerging evidence suggests senescence is a dynamic process with diverse functional characteristics. Depending on the tissue, type of inducer, and time since induction, senescent cells can promote tissue repair and re-modeling, prevent tumor development, or contribute to age-related disorders and chronic diseases, including cancers. Senescent cell characteristics appear to depend on multiple factors and be influenced by the milieu and other senescent cells locally and at a distance. We review diverse phenotypes of senescent cells originating from different cell types, senescence inducers over time since induction of senescence, and across conditions and diseases. This background is essential to inform further understanding about senescent cell subtypes and will point towards rational senescence-modulating strategies for achieving therapeutic benefit.
AB - Cellular senescence, first observed and defined through cell culture studies, is a cell fate associated with essentially permanent cell cycle arrest and that can be triggered by a variety of inducers. Emerging evidence suggests senescence is a dynamic process with diverse functional characteristics. Depending on the tissue, type of inducer, and time since induction, senescent cells can promote tissue repair and re-modeling, prevent tumor development, or contribute to age-related disorders and chronic diseases, including cancers. Senescent cell characteristics appear to depend on multiple factors and be influenced by the milieu and other senescent cells locally and at a distance. We review diverse phenotypes of senescent cells originating from different cell types, senescence inducers over time since induction of senescence, and across conditions and diseases. This background is essential to inform further understanding about senescent cell subtypes and will point towards rational senescence-modulating strategies for achieving therapeutic benefit.
KW - Cellular senescence
KW - Deleterious senescent cell subtype
KW - Helper senescent cell subtype
KW - Senolytics
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U2 - 10.1016/j.mad.2021.111548
DO - 10.1016/j.mad.2021.111548
M3 - Article
C2 - 34352325
AN - SCOPUS:85111681164
SN - 0047-6374
VL - 198
JO - Mechanisms of Ageing and Development
JF - Mechanisms of Ageing and Development
M1 - 111548
ER -