Impact of Personality on Cognitive Aging

A Prospective Cohort Study

Richard John Caselli, Amylou Dueck, Dona E Locke, Bruce R. Henslin, Travis A. Johnson, Bryan K Woodruff, Charlene Hoffman-Snyder, Yonas Endale Geda

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Objectives: The aim of this study was to assess the association between personality factors and age-related longitudinal cognitive performance, and explore interactions of stress-proneness with apolipoprotein E (APOE) ϵ4, a prevalent risk factor for Alzheimer's disease (AD). Methods: A total of 510 neuropsychiatrically healthy residents of Maricopa County recruited through media ads (mean age 57.6±10.6 years; 70% women; mean education 15.8±2.4 years; 213 APOE ϵ4 carriers) had neuropsychological testing every 2 years (mean duration follow-up 9.1±4.4 years), and the complete Neuroticism Extraversion Openness Personality Inventory-Revised. Several tests were administered within each of the following cognitive domains: memory, executive skills, language, visuospatial skills, and general cognition. Primary effects on cognitive trajectories and APOE ϵ4 interactions were ascertained with quadratic models. Results: With personality factors treated as continuous variables, Neuroticism was associated with greater decline, and Conscientiousness associated with reduced decline consistently across tests in memory and executive domains. With personality factors trichotomized, the associations of Neuroticism and Conscientiousness were again highly consistent across tests within memory and to a lesser degree executive domains. While age-related memory decline was greater in APOE ϵ4 carriers as a group than ϵ4 noncarriers, verbal memory decline was mitigated in ϵ4 carriers with higher Conscientiousness, and visuospatial perception and memory decline was mitigated in ϵ4 carriers with higher Openness. Conclusions: Neuroticism and Conscientiousness were associated with changes in longitudinal performances on tests sensitive to memory and executive skills. APOE interactions were less consistent. Our findings are consistent with previous studies that have suggested that personality factors, particularly Neuroticism and Conscientiousness are associated with cognitive aging patterns.

Original languageEnglish (US)
Pages (from-to)765-776
Number of pages12
JournalJournal of the International Neuropsychological Society
Volume22
Issue number7
DOIs
StatePublished - Aug 1 2016

Fingerprint

Personality
neuroticism
personality
Cohort Studies
Apolipoprotein E4
Prospective Studies
personality traits
interaction
Personality Inventory
Age Factors
Apolipoproteins E
Cognitive Aging
Cohort
dementia
Cognition
performance
cognition
Neuroticism
Conscientiousness
Alzheimer Disease

Keywords

  • Aging
  • Alzheimer disease
  • Apolipoprotein E
  • Memory
  • Mild cognitive impairment
  • Psychological stress

ASJC Scopus subject areas

  • Neuroscience(all)
  • Language and Linguistics
  • Clinical Psychology
  • Linguistics and Language
  • Clinical Neurology
  • Psychiatry and Mental health

Cite this

Impact of Personality on Cognitive Aging : A Prospective Cohort Study. / Caselli, Richard John; Dueck, Amylou; Locke, Dona E; Henslin, Bruce R.; Johnson, Travis A.; Woodruff, Bryan K; Hoffman-Snyder, Charlene; Geda, Yonas Endale.

In: Journal of the International Neuropsychological Society, Vol. 22, No. 7, 01.08.2016, p. 765-776.

Research output: Contribution to journalArticle

@article{265c99dd045649eaaaa5941238276e15,
title = "Impact of Personality on Cognitive Aging: A Prospective Cohort Study",
abstract = "Objectives: The aim of this study was to assess the association between personality factors and age-related longitudinal cognitive performance, and explore interactions of stress-proneness with apolipoprotein E (APOE) ϵ4, a prevalent risk factor for Alzheimer's disease (AD). Methods: A total of 510 neuropsychiatrically healthy residents of Maricopa County recruited through media ads (mean age 57.6±10.6 years; 70{\%} women; mean education 15.8±2.4 years; 213 APOE ϵ4 carriers) had neuropsychological testing every 2 years (mean duration follow-up 9.1±4.4 years), and the complete Neuroticism Extraversion Openness Personality Inventory-Revised. Several tests were administered within each of the following cognitive domains: memory, executive skills, language, visuospatial skills, and general cognition. Primary effects on cognitive trajectories and APOE ϵ4 interactions were ascertained with quadratic models. Results: With personality factors treated as continuous variables, Neuroticism was associated with greater decline, and Conscientiousness associated with reduced decline consistently across tests in memory and executive domains. With personality factors trichotomized, the associations of Neuroticism and Conscientiousness were again highly consistent across tests within memory and to a lesser degree executive domains. While age-related memory decline was greater in APOE ϵ4 carriers as a group than ϵ4 noncarriers, verbal memory decline was mitigated in ϵ4 carriers with higher Conscientiousness, and visuospatial perception and memory decline was mitigated in ϵ4 carriers with higher Openness. Conclusions: Neuroticism and Conscientiousness were associated with changes in longitudinal performances on tests sensitive to memory and executive skills. APOE interactions were less consistent. Our findings are consistent with previous studies that have suggested that personality factors, particularly Neuroticism and Conscientiousness are associated with cognitive aging patterns.",
keywords = "Aging, Alzheimer disease, Apolipoprotein E, Memory, Mild cognitive impairment, Psychological stress",
author = "Caselli, {Richard John} and Amylou Dueck and Locke, {Dona E} and Henslin, {Bruce R.} and Johnson, {Travis A.} and Woodruff, {Bryan K} and Charlene Hoffman-Snyder and Geda, {Yonas Endale}",
year = "2016",
month = "8",
day = "1",
doi = "10.1017/S1355617716000527",
language = "English (US)",
volume = "22",
pages = "765--776",
journal = "Journal of the International Neuropsychological Society",
issn = "1355-6177",
publisher = "Cambridge University Press",
number = "7",

}

TY - JOUR

T1 - Impact of Personality on Cognitive Aging

T2 - A Prospective Cohort Study

AU - Caselli, Richard John

AU - Dueck, Amylou

AU - Locke, Dona E

AU - Henslin, Bruce R.

AU - Johnson, Travis A.

AU - Woodruff, Bryan K

AU - Hoffman-Snyder, Charlene

AU - Geda, Yonas Endale

PY - 2016/8/1

Y1 - 2016/8/1

N2 - Objectives: The aim of this study was to assess the association between personality factors and age-related longitudinal cognitive performance, and explore interactions of stress-proneness with apolipoprotein E (APOE) ϵ4, a prevalent risk factor for Alzheimer's disease (AD). Methods: A total of 510 neuropsychiatrically healthy residents of Maricopa County recruited through media ads (mean age 57.6±10.6 years; 70% women; mean education 15.8±2.4 years; 213 APOE ϵ4 carriers) had neuropsychological testing every 2 years (mean duration follow-up 9.1±4.4 years), and the complete Neuroticism Extraversion Openness Personality Inventory-Revised. Several tests were administered within each of the following cognitive domains: memory, executive skills, language, visuospatial skills, and general cognition. Primary effects on cognitive trajectories and APOE ϵ4 interactions were ascertained with quadratic models. Results: With personality factors treated as continuous variables, Neuroticism was associated with greater decline, and Conscientiousness associated with reduced decline consistently across tests in memory and executive domains. With personality factors trichotomized, the associations of Neuroticism and Conscientiousness were again highly consistent across tests within memory and to a lesser degree executive domains. While age-related memory decline was greater in APOE ϵ4 carriers as a group than ϵ4 noncarriers, verbal memory decline was mitigated in ϵ4 carriers with higher Conscientiousness, and visuospatial perception and memory decline was mitigated in ϵ4 carriers with higher Openness. Conclusions: Neuroticism and Conscientiousness were associated with changes in longitudinal performances on tests sensitive to memory and executive skills. APOE interactions were less consistent. Our findings are consistent with previous studies that have suggested that personality factors, particularly Neuroticism and Conscientiousness are associated with cognitive aging patterns.

AB - Objectives: The aim of this study was to assess the association between personality factors and age-related longitudinal cognitive performance, and explore interactions of stress-proneness with apolipoprotein E (APOE) ϵ4, a prevalent risk factor for Alzheimer's disease (AD). Methods: A total of 510 neuropsychiatrically healthy residents of Maricopa County recruited through media ads (mean age 57.6±10.6 years; 70% women; mean education 15.8±2.4 years; 213 APOE ϵ4 carriers) had neuropsychological testing every 2 years (mean duration follow-up 9.1±4.4 years), and the complete Neuroticism Extraversion Openness Personality Inventory-Revised. Several tests were administered within each of the following cognitive domains: memory, executive skills, language, visuospatial skills, and general cognition. Primary effects on cognitive trajectories and APOE ϵ4 interactions were ascertained with quadratic models. Results: With personality factors treated as continuous variables, Neuroticism was associated with greater decline, and Conscientiousness associated with reduced decline consistently across tests in memory and executive domains. With personality factors trichotomized, the associations of Neuroticism and Conscientiousness were again highly consistent across tests within memory and to a lesser degree executive domains. While age-related memory decline was greater in APOE ϵ4 carriers as a group than ϵ4 noncarriers, verbal memory decline was mitigated in ϵ4 carriers with higher Conscientiousness, and visuospatial perception and memory decline was mitigated in ϵ4 carriers with higher Openness. Conclusions: Neuroticism and Conscientiousness were associated with changes in longitudinal performances on tests sensitive to memory and executive skills. APOE interactions were less consistent. Our findings are consistent with previous studies that have suggested that personality factors, particularly Neuroticism and Conscientiousness are associated with cognitive aging patterns.

KW - Aging

KW - Alzheimer disease

KW - Apolipoprotein E

KW - Memory

KW - Mild cognitive impairment

KW - Psychological stress

UR - http://www.scopus.com/inward/record.url?scp=84976315233&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84976315233&partnerID=8YFLogxK

U2 - 10.1017/S1355617716000527

DO - 10.1017/S1355617716000527

M3 - Article

VL - 22

SP - 765

EP - 776

JO - Journal of the International Neuropsychological Society

JF - Journal of the International Neuropsychological Society

SN - 1355-6177

IS - 7

ER -