Impact of Personality on Cognitive Aging: A Prospective Cohort Study

Richard John Caselli, Amylou Dueck, Dona E Locke, Bruce R. Henslin, Travis A. Johnson, Bryan K Woodruff, Charlene Hoffman-Snyder, Yonas Endale Geda

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

Objectives: The aim of this study was to assess the association between personality factors and age-related longitudinal cognitive performance, and explore interactions of stress-proneness with apolipoprotein E (APOE) ϵ4, a prevalent risk factor for Alzheimer's disease (AD). Methods: A total of 510 neuropsychiatrically healthy residents of Maricopa County recruited through media ads (mean age 57.6±10.6 years; 70% women; mean education 15.8±2.4 years; 213 APOE ϵ4 carriers) had neuropsychological testing every 2 years (mean duration follow-up 9.1±4.4 years), and the complete Neuroticism Extraversion Openness Personality Inventory-Revised. Several tests were administered within each of the following cognitive domains: memory, executive skills, language, visuospatial skills, and general cognition. Primary effects on cognitive trajectories and APOE ϵ4 interactions were ascertained with quadratic models. Results: With personality factors treated as continuous variables, Neuroticism was associated with greater decline, and Conscientiousness associated with reduced decline consistently across tests in memory and executive domains. With personality factors trichotomized, the associations of Neuroticism and Conscientiousness were again highly consistent across tests within memory and to a lesser degree executive domains. While age-related memory decline was greater in APOE ϵ4 carriers as a group than ϵ4 noncarriers, verbal memory decline was mitigated in ϵ4 carriers with higher Conscientiousness, and visuospatial perception and memory decline was mitigated in ϵ4 carriers with higher Openness. Conclusions: Neuroticism and Conscientiousness were associated with changes in longitudinal performances on tests sensitive to memory and executive skills. APOE interactions were less consistent. Our findings are consistent with previous studies that have suggested that personality factors, particularly Neuroticism and Conscientiousness are associated with cognitive aging patterns.

Original languageEnglish (US)
Pages (from-to)765-776
Number of pages12
JournalJournal of the International Neuropsychological Society
Volume22
Issue number7
DOIs
StatePublished - Aug 1 2016

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Keywords

  • Aging
  • Alzheimer disease
  • Apolipoprotein E
  • Memory
  • Mild cognitive impairment
  • Psychological stress

ASJC Scopus subject areas

  • Neuroscience(all)
  • Language and Linguistics
  • Clinical Psychology
  • Linguistics and Language
  • Clinical Neurology
  • Psychiatry and Mental health

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