Impact of molecular adsorbent recirculating system therapy on tacrolimus elimination: A case report

H. A. Personett, S. L. Larson, E. N. Frazee, S. L. Nyberg, N. Leung, Z. M. El-Zoghby

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Background We report a unique case which quantifies the effect of molecular adsorbent recirculating system (MARS [Gambro, Sweden]) therapy on blood concentrations of tacrolimus in a patient treated for refractory pruritus associated with recurrent hepatitis C of the liver allograft. Tacrolimus is a low-molecular-weight, highly protein-bound drug with the potential to be removed during MARS therapy.

Case Report Results of therapeutic drug monitoring revealed extracorporeal tacrolimus elimination accounted for only 0.3% of total drug removal during the session.

Conclusions Although no explanation can be offered as to why MARS contributed so little to overall tacrolimus elimination, the data clearly show minimal impact of MARS on tacrolimus blood level.

Original languageEnglish (US)
Pages (from-to)2440-2442
Number of pages3
JournalTransplantation proceedings
Volume46
Issue number7
DOIs
StatePublished - Sep 1 2014

ASJC Scopus subject areas

  • Surgery
  • Transplantation

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