Impact of hypercortisolism on skeletal muscle mass and adipose tissue mass in patients with adrenal adenomas

Danae A. Delivanis, Nicole M. Iñiguez-Ariza, Muhammad H. Zeb, Michael R. Moynagh, Naoki Takahashi, Travis J. Mckenzie, Melinda A. Thomas, Charalambos Gogos, William Francis Young, Irina Bancos, Venetsana Kyriazopoulou

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Context: Abdominal visceral adiposity and central sarcopenia are markers of increased cardiovascular risk and mortality. Objective: To assess whether central sarcopenia and adiposity can serve as a marker of disease severity in patients with adrenal adenomas and glucocorticoid secretory autonomy. Design: Retrospective cohort study. Patients: Twenty-five patients with overt Cushing's syndrome (CS), 48 patients with mild autonomous cortisol excess (MACE) and 32 patients with a nonfunctioning adrenal tumour (NFAT) were included. Methods: Medical records were reviewed, and body composition measurements (visceral fat [VAT], subcutaneous fat [SAT], visceral/total fat [V/T], visceral/subcutaneous [V/S] and total abdominal muscle mass) were calculated based on abdominal computed tomography (CT). Results: In patients with overt CS, when compared to patients with NFAT, the V/T fat and the V/S ratio were increased by 0.08 (P < .001) and by 0.3 (P < .001); however, these measurements were decreased by 0.04 (P = .007) and 0.2 (P = .01), respectively, in patients with MACE. Total muscle mass was decreased by -10 cm2 (P = .02) in patients with overt CS compared to patients with NFAT. Correlation with morning serum cortisol concentrations after dexamethasone suppression testing revealed that for every 28 nmol/L cortisol increase there was a 0.008 increase in V/T (P < .001), 0.02 increase in the V/S fat ratio (P < .001) and a 1.2 cm2 decrease in mean total muscle mass (P = .002). Conclusions: The severity of hypercortisolism was correlated with lower muscle mass and higher visceral adiposity. These CT-based markers may allow for a more reliable and objective assessment of glucocorticoid-related disease severity in patients with adrenal adenomas.

Original languageEnglish (US)
JournalClinical Endocrinology
DOIs
StateAccepted/In press - Jan 1 2017

Fingerprint

Cushing Syndrome
Adenoma
Adipose Tissue
Skeletal Muscle
Intra-Abdominal Fat
Muscles
Glandular and Epithelial Neoplasms
Hydrocortisone
Subcutaneous Fat
Adiposity
Sarcopenia
Glucocorticoids
Tomography
Abdominal Muscles
Body Composition
Dexamethasone
Medical Records
Cohort Studies
Retrospective Studies

Keywords

  • Cardiovascular risk
  • Cushing's syndrome
  • Hypercortisolemia
  • Subcutaneous fat
  • Visceral fat

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism

Cite this

Delivanis, D. A., Iñiguez-Ariza, N. M., Zeb, M. H., Moynagh, M. R., Takahashi, N., Mckenzie, T. J., ... Kyriazopoulou, V. (Accepted/In press). Impact of hypercortisolism on skeletal muscle mass and adipose tissue mass in patients with adrenal adenomas. Clinical Endocrinology. https://doi.org/10.1111/cen.13512

Impact of hypercortisolism on skeletal muscle mass and adipose tissue mass in patients with adrenal adenomas. / Delivanis, Danae A.; Iñiguez-Ariza, Nicole M.; Zeb, Muhammad H.; Moynagh, Michael R.; Takahashi, Naoki; Mckenzie, Travis J.; Thomas, Melinda A.; Gogos, Charalambos; Young, William Francis; Bancos, Irina; Kyriazopoulou, Venetsana.

In: Clinical Endocrinology, 01.01.2017.

Research output: Contribution to journalArticle

Delivanis, DA, Iñiguez-Ariza, NM, Zeb, MH, Moynagh, MR, Takahashi, N, Mckenzie, TJ, Thomas, MA, Gogos, C, Young, WF, Bancos, I & Kyriazopoulou, V 2017, 'Impact of hypercortisolism on skeletal muscle mass and adipose tissue mass in patients with adrenal adenomas', Clinical Endocrinology. https://doi.org/10.1111/cen.13512
Delivanis, Danae A. ; Iñiguez-Ariza, Nicole M. ; Zeb, Muhammad H. ; Moynagh, Michael R. ; Takahashi, Naoki ; Mckenzie, Travis J. ; Thomas, Melinda A. ; Gogos, Charalambos ; Young, William Francis ; Bancos, Irina ; Kyriazopoulou, Venetsana. / Impact of hypercortisolism on skeletal muscle mass and adipose tissue mass in patients with adrenal adenomas. In: Clinical Endocrinology. 2017.
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abstract = "Context: Abdominal visceral adiposity and central sarcopenia are markers of increased cardiovascular risk and mortality. Objective: To assess whether central sarcopenia and adiposity can serve as a marker of disease severity in patients with adrenal adenomas and glucocorticoid secretory autonomy. Design: Retrospective cohort study. Patients: Twenty-five patients with overt Cushing's syndrome (CS), 48 patients with mild autonomous cortisol excess (MACE) and 32 patients with a nonfunctioning adrenal tumour (NFAT) were included. Methods: Medical records were reviewed, and body composition measurements (visceral fat [VAT], subcutaneous fat [SAT], visceral/total fat [V/T], visceral/subcutaneous [V/S] and total abdominal muscle mass) were calculated based on abdominal computed tomography (CT). Results: In patients with overt CS, when compared to patients with NFAT, the V/T fat and the V/S ratio were increased by 0.08 (P < .001) and by 0.3 (P < .001); however, these measurements were decreased by 0.04 (P = .007) and 0.2 (P = .01), respectively, in patients with MACE. Total muscle mass was decreased by -10 cm2 (P = .02) in patients with overt CS compared to patients with NFAT. Correlation with morning serum cortisol concentrations after dexamethasone suppression testing revealed that for every 28 nmol/L cortisol increase there was a 0.008 increase in V/T (P < .001), 0.02 increase in the V/S fat ratio (P < .001) and a 1.2 cm2 decrease in mean total muscle mass (P = .002). Conclusions: The severity of hypercortisolism was correlated with lower muscle mass and higher visceral adiposity. These CT-based markers may allow for a more reliable and objective assessment of glucocorticoid-related disease severity in patients with adrenal adenomas.",
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AU - Delivanis, Danae A.

AU - Iñiguez-Ariza, Nicole M.

AU - Zeb, Muhammad H.

AU - Moynagh, Michael R.

AU - Takahashi, Naoki

AU - Mckenzie, Travis J.

AU - Thomas, Melinda A.

AU - Gogos, Charalambos

AU - Young, William Francis

AU - Bancos, Irina

AU - Kyriazopoulou, Venetsana

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N2 - Context: Abdominal visceral adiposity and central sarcopenia are markers of increased cardiovascular risk and mortality. Objective: To assess whether central sarcopenia and adiposity can serve as a marker of disease severity in patients with adrenal adenomas and glucocorticoid secretory autonomy. Design: Retrospective cohort study. Patients: Twenty-five patients with overt Cushing's syndrome (CS), 48 patients with mild autonomous cortisol excess (MACE) and 32 patients with a nonfunctioning adrenal tumour (NFAT) were included. Methods: Medical records were reviewed, and body composition measurements (visceral fat [VAT], subcutaneous fat [SAT], visceral/total fat [V/T], visceral/subcutaneous [V/S] and total abdominal muscle mass) were calculated based on abdominal computed tomography (CT). Results: In patients with overt CS, when compared to patients with NFAT, the V/T fat and the V/S ratio were increased by 0.08 (P < .001) and by 0.3 (P < .001); however, these measurements were decreased by 0.04 (P = .007) and 0.2 (P = .01), respectively, in patients with MACE. Total muscle mass was decreased by -10 cm2 (P = .02) in patients with overt CS compared to patients with NFAT. Correlation with morning serum cortisol concentrations after dexamethasone suppression testing revealed that for every 28 nmol/L cortisol increase there was a 0.008 increase in V/T (P < .001), 0.02 increase in the V/S fat ratio (P < .001) and a 1.2 cm2 decrease in mean total muscle mass (P = .002). Conclusions: The severity of hypercortisolism was correlated with lower muscle mass and higher visceral adiposity. These CT-based markers may allow for a more reliable and objective assessment of glucocorticoid-related disease severity in patients with adrenal adenomas.

AB - Context: Abdominal visceral adiposity and central sarcopenia are markers of increased cardiovascular risk and mortality. Objective: To assess whether central sarcopenia and adiposity can serve as a marker of disease severity in patients with adrenal adenomas and glucocorticoid secretory autonomy. Design: Retrospective cohort study. Patients: Twenty-five patients with overt Cushing's syndrome (CS), 48 patients with mild autonomous cortisol excess (MACE) and 32 patients with a nonfunctioning adrenal tumour (NFAT) were included. Methods: Medical records were reviewed, and body composition measurements (visceral fat [VAT], subcutaneous fat [SAT], visceral/total fat [V/T], visceral/subcutaneous [V/S] and total abdominal muscle mass) were calculated based on abdominal computed tomography (CT). Results: In patients with overt CS, when compared to patients with NFAT, the V/T fat and the V/S ratio were increased by 0.08 (P < .001) and by 0.3 (P < .001); however, these measurements were decreased by 0.04 (P = .007) and 0.2 (P = .01), respectively, in patients with MACE. Total muscle mass was decreased by -10 cm2 (P = .02) in patients with overt CS compared to patients with NFAT. Correlation with morning serum cortisol concentrations after dexamethasone suppression testing revealed that for every 28 nmol/L cortisol increase there was a 0.008 increase in V/T (P < .001), 0.02 increase in the V/S fat ratio (P < .001) and a 1.2 cm2 decrease in mean total muscle mass (P = .002). Conclusions: The severity of hypercortisolism was correlated with lower muscle mass and higher visceral adiposity. These CT-based markers may allow for a more reliable and objective assessment of glucocorticoid-related disease severity in patients with adrenal adenomas.

KW - Cardiovascular risk

KW - Cushing's syndrome

KW - Hypercortisolemia

KW - Subcutaneous fat

KW - Visceral fat

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