Impact of extracardiac vascular disease on vein graft failure and outcomes after coronary artery bypass surgery

Ralf E. Harskamp, John H. Alexander, Phillip Schulte, W. Schuyler Jones, Judson B. Williams, Michael J. Mack, Eric D. Peterson, C. Michael Gibson, Robert M. Califf, Nicholas T. Kouchoukos, T. Bruce Ferguson, Robbert J. De Winter, Renato D. Lopes

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Background While extracardiac vascular disease (ECVD), defined as a history of peripheral vascular disease (PVD) or cerebrovascular disease (CBVD), is common in patients undergoing coronary artery bypass graft (CABG) surgery, there are limited data available on the association between ECVD, vein graft failure (VGF), and clinical outcomes. Methods Using data from the Project of Ex-vivo Vein Graft Engineering via Transfection IV (PREVENTIV) trial (n = 3,014), 1-year angiographic follow-up and 5-year clinical outcomes (death, myocardial infarction, and revascularization) were determined in patients with and without ECVD. Logistic regression was used to assess risk of VGF. Generalized estimating equations methods were used to account for correlations in a graft-level analysis. Kaplan-Meier estimates and Cox hazards regression were used to compare clinical outcomes. We similarly explored the association of the individual components CBVD and PVD with both VGF and clinical outcomes in an additive model. Results Patients with ECVD (n = 634, 21%) were older, more commonly female, and had more comorbidities, lower use of internal thoracic artery grafting, and overall worse graft quality than patients without ECVD. VGF rates tended to be higher (patient-level: odds ratio [OR]: 1.23, 95% confidence interval [CI] 0.96 to 1.58, p = 0.099; graft-level: OR: 1.23, 95% CI: 1.00 to 1.53, p = 0.053) in patients with ECVD. VGF rates were significantly higher among CBVD patients (OR: 1.42, 95% CI: 1.03 to 1.97, p = 0.035; graft-level: OR: 1.40, 95% CI: 1.06 to 1.85, p = 0.019). Patients with ECVD had a higher risk of death, myocardial infarction, or revascularization 5 years after CABG surgery (hazard ratio [HR]: 2.96, 95% CI: 2.02 to 4.35, p < 0.001). This relationship was driven by the subset of patients with PVD (HR = 3.32, 95% CI: 2.16 to 5.09, p < 0.001) and not by those with CBVD (HR = 1.10, 95% CI: 0.88 to 1.37, p = 0.40). Conclusions ECVD is common among patients undergoing CABG surgery and is associated with similar short-term but increasingly worse long-term clinical outcomes. This higher risk may be partly, but not exclusively, due to higher rates of VGF among these patients.

Original languageEnglish (US)
Pages (from-to)824-830
Number of pages7
JournalAnnals of Thoracic Surgery
Volume97
Issue number3
DOIs
StatePublished - Mar 2014
Externally publishedYes

Fingerprint

Vascular Diseases
Coronary Artery Bypass
Veins
Transplants
Cerebrovascular Disorders
Confidence Intervals
Peripheral Vascular Diseases
Odds Ratio
Myocardial Revascularization
Myocardial Infarction
Mammary Arteries
Kaplan-Meier Estimate
Transfection
Comorbidity
Logistic Models

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Surgery
  • Pulmonary and Respiratory Medicine

Cite this

Impact of extracardiac vascular disease on vein graft failure and outcomes after coronary artery bypass surgery. / Harskamp, Ralf E.; Alexander, John H.; Schulte, Phillip; Jones, W. Schuyler; Williams, Judson B.; Mack, Michael J.; Peterson, Eric D.; Gibson, C. Michael; Califf, Robert M.; Kouchoukos, Nicholas T.; Ferguson, T. Bruce; De Winter, Robbert J.; Lopes, Renato D.

In: Annals of Thoracic Surgery, Vol. 97, No. 3, 03.2014, p. 824-830.

Research output: Contribution to journalArticle

Harskamp, RE, Alexander, JH, Schulte, P, Jones, WS, Williams, JB, Mack, MJ, Peterson, ED, Gibson, CM, Califf, RM, Kouchoukos, NT, Ferguson, TB, De Winter, RJ & Lopes, RD 2014, 'Impact of extracardiac vascular disease on vein graft failure and outcomes after coronary artery bypass surgery', Annals of Thoracic Surgery, vol. 97, no. 3, pp. 824-830. https://doi.org/10.1016/j.athoracsur.2013.09.099
Harskamp, Ralf E. ; Alexander, John H. ; Schulte, Phillip ; Jones, W. Schuyler ; Williams, Judson B. ; Mack, Michael J. ; Peterson, Eric D. ; Gibson, C. Michael ; Califf, Robert M. ; Kouchoukos, Nicholas T. ; Ferguson, T. Bruce ; De Winter, Robbert J. ; Lopes, Renato D. / Impact of extracardiac vascular disease on vein graft failure and outcomes after coronary artery bypass surgery. In: Annals of Thoracic Surgery. 2014 ; Vol. 97, No. 3. pp. 824-830.
@article{24bbd80d36a44c66894fde1c23d2e2c2,
title = "Impact of extracardiac vascular disease on vein graft failure and outcomes after coronary artery bypass surgery",
abstract = "Background While extracardiac vascular disease (ECVD), defined as a history of peripheral vascular disease (PVD) or cerebrovascular disease (CBVD), is common in patients undergoing coronary artery bypass graft (CABG) surgery, there are limited data available on the association between ECVD, vein graft failure (VGF), and clinical outcomes. Methods Using data from the Project of Ex-vivo Vein Graft Engineering via Transfection IV (PREVENTIV) trial (n = 3,014), 1-year angiographic follow-up and 5-year clinical outcomes (death, myocardial infarction, and revascularization) were determined in patients with and without ECVD. Logistic regression was used to assess risk of VGF. Generalized estimating equations methods were used to account for correlations in a graft-level analysis. Kaplan-Meier estimates and Cox hazards regression were used to compare clinical outcomes. We similarly explored the association of the individual components CBVD and PVD with both VGF and clinical outcomes in an additive model. Results Patients with ECVD (n = 634, 21{\%}) were older, more commonly female, and had more comorbidities, lower use of internal thoracic artery grafting, and overall worse graft quality than patients without ECVD. VGF rates tended to be higher (patient-level: odds ratio [OR]: 1.23, 95{\%} confidence interval [CI] 0.96 to 1.58, p = 0.099; graft-level: OR: 1.23, 95{\%} CI: 1.00 to 1.53, p = 0.053) in patients with ECVD. VGF rates were significantly higher among CBVD patients (OR: 1.42, 95{\%} CI: 1.03 to 1.97, p = 0.035; graft-level: OR: 1.40, 95{\%} CI: 1.06 to 1.85, p = 0.019). Patients with ECVD had a higher risk of death, myocardial infarction, or revascularization 5 years after CABG surgery (hazard ratio [HR]: 2.96, 95{\%} CI: 2.02 to 4.35, p < 0.001). This relationship was driven by the subset of patients with PVD (HR = 3.32, 95{\%} CI: 2.16 to 5.09, p < 0.001) and not by those with CBVD (HR = 1.10, 95{\%} CI: 0.88 to 1.37, p = 0.40). Conclusions ECVD is common among patients undergoing CABG surgery and is associated with similar short-term but increasingly worse long-term clinical outcomes. This higher risk may be partly, but not exclusively, due to higher rates of VGF among these patients.",
author = "Harskamp, {Ralf E.} and Alexander, {John H.} and Phillip Schulte and Jones, {W. Schuyler} and Williams, {Judson B.} and Mack, {Michael J.} and Peterson, {Eric D.} and Gibson, {C. Michael} and Califf, {Robert M.} and Kouchoukos, {Nicholas T.} and Ferguson, {T. Bruce} and {De Winter}, {Robbert J.} and Lopes, {Renato D.}",
year = "2014",
month = "3",
doi = "10.1016/j.athoracsur.2013.09.099",
language = "English (US)",
volume = "97",
pages = "824--830",
journal = "Annals of Thoracic Surgery",
issn = "0003-4975",
publisher = "Elsevier USA",
number = "3",

}

TY - JOUR

T1 - Impact of extracardiac vascular disease on vein graft failure and outcomes after coronary artery bypass surgery

AU - Harskamp, Ralf E.

AU - Alexander, John H.

AU - Schulte, Phillip

AU - Jones, W. Schuyler

AU - Williams, Judson B.

AU - Mack, Michael J.

AU - Peterson, Eric D.

AU - Gibson, C. Michael

AU - Califf, Robert M.

AU - Kouchoukos, Nicholas T.

AU - Ferguson, T. Bruce

AU - De Winter, Robbert J.

AU - Lopes, Renato D.

PY - 2014/3

Y1 - 2014/3

N2 - Background While extracardiac vascular disease (ECVD), defined as a history of peripheral vascular disease (PVD) or cerebrovascular disease (CBVD), is common in patients undergoing coronary artery bypass graft (CABG) surgery, there are limited data available on the association between ECVD, vein graft failure (VGF), and clinical outcomes. Methods Using data from the Project of Ex-vivo Vein Graft Engineering via Transfection IV (PREVENTIV) trial (n = 3,014), 1-year angiographic follow-up and 5-year clinical outcomes (death, myocardial infarction, and revascularization) were determined in patients with and without ECVD. Logistic regression was used to assess risk of VGF. Generalized estimating equations methods were used to account for correlations in a graft-level analysis. Kaplan-Meier estimates and Cox hazards regression were used to compare clinical outcomes. We similarly explored the association of the individual components CBVD and PVD with both VGF and clinical outcomes in an additive model. Results Patients with ECVD (n = 634, 21%) were older, more commonly female, and had more comorbidities, lower use of internal thoracic artery grafting, and overall worse graft quality than patients without ECVD. VGF rates tended to be higher (patient-level: odds ratio [OR]: 1.23, 95% confidence interval [CI] 0.96 to 1.58, p = 0.099; graft-level: OR: 1.23, 95% CI: 1.00 to 1.53, p = 0.053) in patients with ECVD. VGF rates were significantly higher among CBVD patients (OR: 1.42, 95% CI: 1.03 to 1.97, p = 0.035; graft-level: OR: 1.40, 95% CI: 1.06 to 1.85, p = 0.019). Patients with ECVD had a higher risk of death, myocardial infarction, or revascularization 5 years after CABG surgery (hazard ratio [HR]: 2.96, 95% CI: 2.02 to 4.35, p < 0.001). This relationship was driven by the subset of patients with PVD (HR = 3.32, 95% CI: 2.16 to 5.09, p < 0.001) and not by those with CBVD (HR = 1.10, 95% CI: 0.88 to 1.37, p = 0.40). Conclusions ECVD is common among patients undergoing CABG surgery and is associated with similar short-term but increasingly worse long-term clinical outcomes. This higher risk may be partly, but not exclusively, due to higher rates of VGF among these patients.

AB - Background While extracardiac vascular disease (ECVD), defined as a history of peripheral vascular disease (PVD) or cerebrovascular disease (CBVD), is common in patients undergoing coronary artery bypass graft (CABG) surgery, there are limited data available on the association between ECVD, vein graft failure (VGF), and clinical outcomes. Methods Using data from the Project of Ex-vivo Vein Graft Engineering via Transfection IV (PREVENTIV) trial (n = 3,014), 1-year angiographic follow-up and 5-year clinical outcomes (death, myocardial infarction, and revascularization) were determined in patients with and without ECVD. Logistic regression was used to assess risk of VGF. Generalized estimating equations methods were used to account for correlations in a graft-level analysis. Kaplan-Meier estimates and Cox hazards regression were used to compare clinical outcomes. We similarly explored the association of the individual components CBVD and PVD with both VGF and clinical outcomes in an additive model. Results Patients with ECVD (n = 634, 21%) were older, more commonly female, and had more comorbidities, lower use of internal thoracic artery grafting, and overall worse graft quality than patients without ECVD. VGF rates tended to be higher (patient-level: odds ratio [OR]: 1.23, 95% confidence interval [CI] 0.96 to 1.58, p = 0.099; graft-level: OR: 1.23, 95% CI: 1.00 to 1.53, p = 0.053) in patients with ECVD. VGF rates were significantly higher among CBVD patients (OR: 1.42, 95% CI: 1.03 to 1.97, p = 0.035; graft-level: OR: 1.40, 95% CI: 1.06 to 1.85, p = 0.019). Patients with ECVD had a higher risk of death, myocardial infarction, or revascularization 5 years after CABG surgery (hazard ratio [HR]: 2.96, 95% CI: 2.02 to 4.35, p < 0.001). This relationship was driven by the subset of patients with PVD (HR = 3.32, 95% CI: 2.16 to 5.09, p < 0.001) and not by those with CBVD (HR = 1.10, 95% CI: 0.88 to 1.37, p = 0.40). Conclusions ECVD is common among patients undergoing CABG surgery and is associated with similar short-term but increasingly worse long-term clinical outcomes. This higher risk may be partly, but not exclusively, due to higher rates of VGF among these patients.

UR - http://www.scopus.com/inward/record.url?scp=84896727763&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84896727763&partnerID=8YFLogxK

U2 - 10.1016/j.athoracsur.2013.09.099

DO - 10.1016/j.athoracsur.2013.09.099

M3 - Article

C2 - 24360877

AN - SCOPUS:84896727763

VL - 97

SP - 824

EP - 830

JO - Annals of Thoracic Surgery

JF - Annals of Thoracic Surgery

SN - 0003-4975

IS - 3

ER -