TY - JOUR
T1 - Impact of Consensus Definitions on Identification of Glomerular Lesions by Light and Electron Microscopy
AU - Haas, Mark
AU - Mirocha, James
AU - Amann, Kerstin
AU - Bajema, Ingeborg M.
AU - Barisoni, Laura
AU - Becker, Jan Ulrich
AU - Jennette, J. Charles
AU - Joh, Kenuske
AU - Ljubanovic, Danica Galesic
AU - Roberts, Ian S.D.
AU - Roelofs, Joris J.
AU - Sethi, Sanjeev
AU - Suarez, Raul
AU - Zeng, Caihong
AU - Seshan, Surya V.
N1 - Publisher Copyright:
© 2021 International Society of Nephrology
PY - 2022/1
Y1 - 2022/1
N2 - Introduction: In 2020, a working group of 13 renal pathologists published consensus definitions for 47 individual glomerular lesions found on light microscopy (LM) and 47 glomerular lesions and 9 normal structures found on electron microscopy (EM). Methods: To test the impact of these definitions on identification of these lesions and structures, 2 surveys were circulated to all members of the Renal Pathology Society (RPS), each having 32 images (19 LM, 13 EM) and accompanying questions with 5 multiple-choice answers, one being the consensus choice of the working group. The first survey (survey 1 [S1]), answered by 297 RPS members, was sent in September 2020, before publication of the consensus definitions. The second (survey 2 [S2]), with images of the same lesions and structures (but not the same images) and the same questions and multiple choices in different order, was sent in April 2020, 5 months after the publication of the definitions. Results: S2 was taken by 181 RPS members; 64% also took S1 and 61% reported having read the definitions paper (def. paper). Mean agreement with the consensus answers increased modestly between the 2 surveys (65.2% vs. 72.0%, P = 0.097); the increase was greater and significant when only respondents to S2 who read the def. paper were considered (65.2% vs. 74.8%, P = 0.026). Furthermore, in S2 agreement with consensus answers was greater among respondents who read this paper versus those who did not (66.9% vs. 74.8%, P < 0.0001). Conclusions: Publication of the consensus definitions modestly improved interobserver agreement in identification of glomerular lesions.
AB - Introduction: In 2020, a working group of 13 renal pathologists published consensus definitions for 47 individual glomerular lesions found on light microscopy (LM) and 47 glomerular lesions and 9 normal structures found on electron microscopy (EM). Methods: To test the impact of these definitions on identification of these lesions and structures, 2 surveys were circulated to all members of the Renal Pathology Society (RPS), each having 32 images (19 LM, 13 EM) and accompanying questions with 5 multiple-choice answers, one being the consensus choice of the working group. The first survey (survey 1 [S1]), answered by 297 RPS members, was sent in September 2020, before publication of the consensus definitions. The second (survey 2 [S2]), with images of the same lesions and structures (but not the same images) and the same questions and multiple choices in different order, was sent in April 2020, 5 months after the publication of the definitions. Results: S2 was taken by 181 RPS members; 64% also took S1 and 61% reported having read the definitions paper (def. paper). Mean agreement with the consensus answers increased modestly between the 2 surveys (65.2% vs. 72.0%, P = 0.097); the increase was greater and significant when only respondents to S2 who read the def. paper were considered (65.2% vs. 74.8%, P = 0.026). Furthermore, in S2 agreement with consensus answers was greater among respondents who read this paper versus those who did not (66.9% vs. 74.8%, P < 0.0001). Conclusions: Publication of the consensus definitions modestly improved interobserver agreement in identification of glomerular lesions.
KW - electron microscopy
KW - glomerulonephritis
KW - glomerulus
KW - kidney biopsy
KW - renal pathology
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U2 - 10.1016/j.ekir.2021.10.014
DO - 10.1016/j.ekir.2021.10.014
M3 - Article
AN - SCOPUS:85119253432
SN - 2468-0249
VL - 7
SP - 78
EP - 86
JO - Kidney International Reports
JF - Kidney International Reports
IS - 1
ER -