Impact of body mass index on immunogenicity of pandemic H1N1 vaccine in children and adults

S. Todd Callahan, Mark Wolff, Heather R. Hill, Kathryn M. Edwards, Wendy Keitel, Robert Atmar, Shital Patel, Hana El Sahly, Flor Munoz, W. Paul Glezen, Rebecca Brady, Robert Frenck, David Bernstein, Christopher Harrison, Mary Anne Jackson, Douglas Swanson, Jason Newland, Angela Myers, Robyn A. Livingston, Emmanuel WalterRowena Dolor, Kenneth Schmader, Mark J. Mulligan, Srilatha Edupuganti, Nadine Rouphael, Jennifer Whitaker, Paul Spearman, Harry Keyserling, Andi Shane, Allison Ross Eckard, Lisa A. Jackson, Sharon E. Frey, Robert B. Belshe, Irene Graham, Edwin Anderson, Janet A. Englund, Sara Healy, Patricia Winokur, Jack Stapleton, Jeffrey Meier, Karen Kotloff, Wilbur Chen, Julia Hutter, Ina Stephens, Susan Wooten, Anna Wald

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

Obesity emerged as a risk factor for morbidity and mortality related to 2009 pandemic influenza A (H1N1) infection. However, few studies examine the immune responses to H1N1 vaccine among children and adults of various body mass indices (BMI). Pooling data from 3 trials of unadjuvanted split-virus H1N1 A/California/07/2009 influenza vaccines, we analyzed serologic responses of participants stratified by BMI grouping. A single vaccine dose produced higher hemagglutination inhibition antibody titers at day 21 in obese compared to nonobese adults, but there were no significant differences in responses to H1N1 vaccine among children or adults of various BMI following 2 doses.

Original languageEnglish (US)
Pages (from-to)1270-1274
Number of pages5
JournalJournal of Infectious Diseases
Volume210
Issue number8
DOIs
StatePublished - Jan 1 2014

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Keywords

  • Body mass index
  • Immune response
  • Influenza vaccine
  • Obesity

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

Cite this

Callahan, S. T., Wolff, M., Hill, H. R., Edwards, K. M., Keitel, W., Atmar, R., Patel, S., El Sahly, H., Munoz, F., Glezen, W. P., Brady, R., Frenck, R., Bernstein, D., Harrison, C., Jackson, M. A., Swanson, D., Newland, J., Myers, A., Livingston, R. A., ... Wald, A. (2014). Impact of body mass index on immunogenicity of pandemic H1N1 vaccine in children and adults. Journal of Infectious Diseases, 210(8), 1270-1274. https://doi.org/10.1093/infdis/jiu245