TY - JOUR
T1 - Impact of access to NCI- and NCCN-designated cancer centers on outcomes for multiple myeloma patients
T2 - A SEER registry analysis
AU - Ailawadhi, Sikander
AU - Advani, Pooja
AU - Yang, Dongyun
AU - Ghosh, Radhika
AU - Swaika, Abhisek
AU - Roy, Vivek
AU - Foran, James
AU - Colon-Otero, Gerardo
AU - Chanan-Khan, Asher
N1 - Publisher Copyright:
© 2015 American Cancer Society.
PY - 2016/2/15
Y1 - 2016/2/15
N2 - BACKGROUND National Cancer Institute (NCI)/National Comprehensive Cancer Network (NCCN)-designated cancer centers (CCs) offer patients state-of-the-art treatment, but their impact on multiple myeloma (MM) patient outcomes has not been evaluated. METHODS Adult MM patients diagnosed between 1973 and 2011 were identified from the Surveillance, Epidemiology, and End Results database and were stratified by the county of residence at the time of diagnosis and the year of CC designation. The influence of NCI/NCCN CC access, race, and the year of diagnosis on overall survival (OS) was evaluated with a Cox regression model. RESULTS A statistically significant OS improvement was noted in patients diagnosed after 1995 with access to 2 or more NCI CCs overall (P =.002 for 1996-2002; P <.001 for 2003-2011) and by race for whites (hazard ratio [HR] for 1996-2002, 0.85; 95% confidence interval [CI], 0.78-0.91; HR for 2003-2011, 0.85; 95% CI, 0.79-0.91) but not for nonwhites. For NCCN access, improvement was seen in 1996-2002 (P =.003), in 2003-2011 (P <.001), and by race for whites (HR, 0.917; 95% CI, 0.88-0.95) and nonwhites (0.94; 95% CI, 0.89-0.99), but within nonwhites, this was true only for African Americans (AAs; HR, 0.88; 95% CI, 0.81-0.97) and not for Asians, Hispanics, or Native Americans. CONCLUSIONS Improvement in OS was seen in MM patients diagnosed after 1995 with access to 1 NCCN CC or 2 or more NCI CCs. NCI access benefited only whites, whereas NCCN access benefited only white and AA patients. No OS benefit was seen for any subgroup with access to only 1 NCI center. Eliminating racial disparities in health care access and utilization is needed to improve outcomes.
AB - BACKGROUND National Cancer Institute (NCI)/National Comprehensive Cancer Network (NCCN)-designated cancer centers (CCs) offer patients state-of-the-art treatment, but their impact on multiple myeloma (MM) patient outcomes has not been evaluated. METHODS Adult MM patients diagnosed between 1973 and 2011 were identified from the Surveillance, Epidemiology, and End Results database and were stratified by the county of residence at the time of diagnosis and the year of CC designation. The influence of NCI/NCCN CC access, race, and the year of diagnosis on overall survival (OS) was evaluated with a Cox regression model. RESULTS A statistically significant OS improvement was noted in patients diagnosed after 1995 with access to 2 or more NCI CCs overall (P =.002 for 1996-2002; P <.001 for 2003-2011) and by race for whites (hazard ratio [HR] for 1996-2002, 0.85; 95% confidence interval [CI], 0.78-0.91; HR for 2003-2011, 0.85; 95% CI, 0.79-0.91) but not for nonwhites. For NCCN access, improvement was seen in 1996-2002 (P =.003), in 2003-2011 (P <.001), and by race for whites (HR, 0.917; 95% CI, 0.88-0.95) and nonwhites (0.94; 95% CI, 0.89-0.99), but within nonwhites, this was true only for African Americans (AAs; HR, 0.88; 95% CI, 0.81-0.97) and not for Asians, Hispanics, or Native Americans. CONCLUSIONS Improvement in OS was seen in MM patients diagnosed after 1995 with access to 1 NCCN CC or 2 or more NCI CCs. NCI access benefited only whites, whereas NCCN access benefited only white and AA patients. No OS benefit was seen for any subgroup with access to only 1 NCI center. Eliminating racial disparities in health care access and utilization is needed to improve outcomes.
KW - National Cancer Institute (NCI) cancer center
KW - National Comprehensive Cancer Network (NCCN) cancer center
KW - multiple myeloma
KW - overall survival
UR - http://www.scopus.com/inward/record.url?scp=84959236170&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84959236170&partnerID=8YFLogxK
U2 - 10.1002/cncr.29771
DO - 10.1002/cncr.29771
M3 - Article
C2 - 26565660
AN - SCOPUS:84959236170
SN - 0008-543X
VL - 122
SP - 618
EP - 625
JO - Cancer
JF - Cancer
IS - 4
ER -