Immunotherapy in pancreatic cancer treatment: A new frontier

Komal Thind, Leslie J. Padrnos, Ramesk K Ramanathan, Mitesh J Borad

Research output: Contribution to journalReview article

36 Scopus citations

Abstract

Pancreatic cancer is a highly aggressive and lethal cancer characterized by high invasiveness, local and extensive dissemination at time of diagnosis and resistance to treatment. Few therapies have shown efficacy in the past and even standard of care therapies yield only modest improvements in the mortality of patients with advanced or metastatic disease. Efforts have been undertaken to study the pancreatic tumor microenvironment and have established its complex and immunosuppressive nature which could explain the high resistance to chemotherapy. Novel therapies targeting the tumor microenvironment with an aim to decrease this resistance, improve immune tolerance and increase the efficacy of the current treatment have shown some promising preliminary results in preclinical and clinical trials. We review the current advances in the field of immunotherapy and their effectiveness as a potential treatment strategy in the pancreatic cancer.

Original languageEnglish (US)
Pages (from-to)168-194
Number of pages27
JournalTherapeutic Advances in Gastroenterology
Volume10
Issue number1
DOIs
StatePublished - Jan 1 2017

Keywords

  • adoptive cellular immunotherapy
  • cancer vaccines
  • immunotherapy
  • pancreatic cancer

ASJC Scopus subject areas

  • Gastroenterology

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