Immunoregulatory cell dysfunction in chronic B-cell leukemias

S. L. Zaknoen, Neil Elliot Kay

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Chronic B-cell malignancies are routinely characterized as B-cell clonal diseases that have signs and symptoms primarily related to the continuing expansion of these cells. This review discusses chronic lymphocytic leukemia, multiple myeloma and hairy cell leukemia from the perspective of secondary abnormalities in non-malignant cells. Thus, our main purpose is to elaborate on the alterations/abnormalities of the immunoregulatory (IR) cells in these diseases and focus on the qualitative and quantitative aspects of T-cells, natural killer (NK) cells and monocytes. The relevance of the IR-cell changes to the basic disease process and their complications are emphasized.

Original languageEnglish (US)
Pages (from-to)165-174
Number of pages10
JournalBlood Reviews
Volume4
Issue number3
DOIs
StatePublished - 1990
Externally publishedYes

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B-Cell Chronic Lymphocytic Leukemia
B-Lymphocytes
Hairy Cell Leukemia
Multiple Myeloma
Natural Killer Cells
Signs and Symptoms
Monocytes
T-Lymphocytes
Neoplasms

ASJC Scopus subject areas

  • Cancer Research
  • Hematology
  • Oncology

Cite this

Immunoregulatory cell dysfunction in chronic B-cell leukemias. / Zaknoen, S. L.; Kay, Neil Elliot.

In: Blood Reviews, Vol. 4, No. 3, 1990, p. 165-174.

Research output: Contribution to journalArticle

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