Immunophenotypic and laboratory features of t(11;14)(q13;q32)-positive plasma cell neoplasms

Min Shi, Jessica A. Ternus, Rhett P. Ketterling, Dragan Jevremovic, Ellen McPhail

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The t(11;14)(q13;32)-positive plasma cell neoplasms (PCNs) are common. In light of their lymphoplasmacytoid features and CD20 expression, we speculated that they may share laboratory features with B-cell lymphomas with plasmacytic differentiation (BCL-PCDs). We investigated flow cytometric CD19 and CD45 expression, DNA ploidy index and M-protein subtype in 416 t(11;14)-positive PCNs, as well as control groups (88 BCL-PCDs and 81 t(11;14)-negative PCNs). The plasma cells from the t(11;14)-positive PCNs were largely CD19−/CD45−, similar to the t(11;14)-negative PCNs and unlike the BCL-PCD plasma cells (p < .0001). 79% of the t(11;14)-positive PCNs were diploid, which was significantly more than in t(11;14)-negative PCNs (p < .0001) and significantly less than in the BCL-PCDs (p < .001). Although IgM secretion was common in BCL-PCDs (80%) and rare in PCNs (3%), most IgM PCNs (92%) were t(11;14)-positive. These findings may be helpful in evaluating specimens with clonal plasma cells in the reference laboratory setting.

Original languageEnglish (US)
Pages (from-to)1-7
Number of pages7
JournalLeukemia and Lymphoma
DOIs
StateAccepted/In press - Dec 8 2017

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Plasma Cell Neoplasms
B-Cell Lymphoma
Plasma Cells
Immunoglobulin M
Ploidies
Diploidy

Keywords

  • Cytogenetics
  • Lymphoma
  • Myeloma
  • t(11;14) plasma cell neoplasm

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

Cite this

Immunophenotypic and laboratory features of t(11;14)(q13;q32)-positive plasma cell neoplasms. / Shi, Min; Ternus, Jessica A.; Ketterling, Rhett P.; Jevremovic, Dragan; McPhail, Ellen.

In: Leukemia and Lymphoma, 08.12.2017, p. 1-7.

Research output: Contribution to journalArticle

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abstract = "The t(11;14)(q13;32)-positive plasma cell neoplasms (PCNs) are common. In light of their lymphoplasmacytoid features and CD20 expression, we speculated that they may share laboratory features with B-cell lymphomas with plasmacytic differentiation (BCL-PCDs). We investigated flow cytometric CD19 and CD45 expression, DNA ploidy index and M-protein subtype in 416 t(11;14)-positive PCNs, as well as control groups (88 BCL-PCDs and 81 t(11;14)-negative PCNs). The plasma cells from the t(11;14)-positive PCNs were largely CD19−/CD45−, similar to the t(11;14)-negative PCNs and unlike the BCL-PCD plasma cells (p < .0001). 79{\%} of the t(11;14)-positive PCNs were diploid, which was significantly more than in t(11;14)-negative PCNs (p < .0001) and significantly less than in the BCL-PCDs (p < .001). Although IgM secretion was common in BCL-PCDs (80{\%}) and rare in PCNs (3{\%}), most IgM PCNs (92{\%}) were t(11;14)-positive. These findings may be helpful in evaluating specimens with clonal plasma cells in the reference laboratory setting.",
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