Immunological aspects of axon injury in multiple sclerosis

C. L. Howe

doi:10.1007/978-3-540-73677-6_5

Immunological aspects of axon injury in multiple sclerosis

C. L. Howe

Neurology

Research output: Chapter in Book/Report/Conference proceeding › Chapter

9 Scopus citations

Abstract

The role of immune-mediated axonal injury in the induction of nonremitting functional deficits associated with multiple sclerosis is an area of active research that promises to substantially alter our understanding of the pathogenesis of this disease and modify or change our therapeutic focus. This review summarizes the current state of research regarding changes in axonal function during demyelination, provides evidence of axonal dysmorphia and degeneration associated with demyelination, and identifies the cellular and molecular effectors of immune-mediated axonal injury. Finally, a unifying hypothesis that links neuronal stress associated with demyelination-induced axonal dysfunction to immune recognition and immunopathology is provided in an effort to shape future experimentation.

Original language	English (US)
Title of host publication	Advances in multiple Sclerosis and Experimental Demyelinating Diseases
Publisher	Springer Verlag
Pages	93-131
Number of pages	39
ISBN (Print)	9783540736769
DOIs	https://doi.org/10.1007/978-3-540-73677-6_5
State	Published - 2008

Publication series

Name	Current Topics in Microbiology and Immunology
Volume	318
ISSN (Print)	0070-217X

ASJC Scopus subject areas

Immunology and Allergy
Microbiology
Immunology
Microbiology (medical)

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10.1007/978-3-540-73677-6_5

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Immunological aspects of axon injury in multiple sclerosis

Abstract

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