Immunologic studies and clinical follow-up HBsAg-positive polyarteritis nodosa

Thomas D. Boyer; Myron J. Tong; Jorge Rakela; Telfer B. Reynolds

doi:10.1007/BF01072501

Immunologic studies and clinical follow-up HB_sAg-positive polyarteritis nodosa

Thomas D. Boyer, Myron J. Tong, Jorge Rakela, Telfer B. Reynolds

Gastroenterology and Hepatology

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11 Scopus citations

Abstract

Three patients with hepatitis B surface antigen (HB_sAg)-positive polyarteritis nodosa (PAN) who are clinically well 41/2-51/2 years after their initial illnesses are described. In each case electron microscopic studies demonstrated the presence of aggregates of HB_sAg in both acute and quiescent phase sera. One patient had a lower circulating HB_sAg titer during the acute illness, while no change in serial HB_sAg titers was observed in the other two patients. Two of the three patients showed lymphocyte transformation to purified HB_sAg during the quiescent phase of the PAN. The role of immune complexes in the pathogenesis of HB_sAg-positive PAN is discussed.

Original language	English (US)
Pages (from-to)	497-501
Number of pages	5
Journal	The American Journal of Digestive Diseases
Volume	22
Issue number	6
DOIs	https://doi.org/10.1007/BF01072501
State	Published - Jun 1977

ASJC Scopus subject areas

Gastroenterology

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10.1007/BF01072501

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title = "Immunologic studies and clinical follow-up HBsAg-positive polyarteritis nodosa",

abstract = "Three patients with hepatitis B surface antigen (HBsAg)-positive polyarteritis nodosa (PAN) who are clinically well 41/2-51/2 years after their initial illnesses are described. In each case electron microscopic studies demonstrated the presence of aggregates of HBsAg in both acute and quiescent phase sera. One patient had a lower circulating HBsAg titer during the acute illness, while no change in serial HBsAg titers was observed in the other two patients. Two of the three patients showed lymphocyte transformation to purified HBsAg during the quiescent phase of the PAN. The role of immune complexes in the pathogenesis of HBsAg-positive PAN is discussed.",

author = "Boyer, {Thomas D.} and Tong, {Myron J.} and Jorge Rakela and Reynolds, {Telfer B.}",

year = "1977",

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AU - Boyer, Thomas D.

AU - Tong, Myron J.

AU - Rakela, Jorge

AU - Reynolds, Telfer B.

PY - 1977/6

Y1 - 1977/6

N2 - Three patients with hepatitis B surface antigen (HBsAg)-positive polyarteritis nodosa (PAN) who are clinically well 41/2-51/2 years after their initial illnesses are described. In each case electron microscopic studies demonstrated the presence of aggregates of HBsAg in both acute and quiescent phase sera. One patient had a lower circulating HBsAg titer during the acute illness, while no change in serial HBsAg titers was observed in the other two patients. Two of the three patients showed lymphocyte transformation to purified HBsAg during the quiescent phase of the PAN. The role of immune complexes in the pathogenesis of HBsAg-positive PAN is discussed.

AB - Three patients with hepatitis B surface antigen (HBsAg)-positive polyarteritis nodosa (PAN) who are clinically well 41/2-51/2 years after their initial illnesses are described. In each case electron microscopic studies demonstrated the presence of aggregates of HBsAg in both acute and quiescent phase sera. One patient had a lower circulating HBsAg titer during the acute illness, while no change in serial HBsAg titers was observed in the other two patients. Two of the three patients showed lymphocyte transformation to purified HBsAg during the quiescent phase of the PAN. The role of immune complexes in the pathogenesis of HBsAg-positive PAN is discussed.

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ER -

Immunologic studies and clinical follow-up HB_sAg-positive polyarteritis nodosa

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