Immunoglobulin light chain amyloidosis and the kidney

Research output: Contribution to journalArticle

69 Citations (Scopus)

Abstract

Amyloidosis (AL) is a common cause of nephrotic syndrome in nondiabetic, nonhypertensive adults. All adult patients with nephrotic syndrome should have immunofixation of serum and urine as a screen. The finding of a monoclonal protein, particularly of lambda type, should lead to a subcutaneous fat aspirate or bone marrow biopsy to search for amyloid deposits. When the result of either test is positive, a kidney biopsy is unnecessary. The prognosis of patients who have renal amyloidosis depends on the concentration of serum creatinine at presentation and whether an echocardiographic evaluation demonstrates infiltrative cardiomyopathy. Most therapies are directed against the plasma cell dyscrasia present in all patients with AL and can include melphalan and prednisone, high-dose dexamethasone, and, most recently, peripheral blood stem cell transplantation.

Original languageEnglish (US)
Pages (from-to)1-9
Number of pages9
JournalKidney International
Volume61
Issue number1
DOIs
StatePublished - 2002

Fingerprint

Immunoglobulin Light Chains
Amyloidosis
Nephrotic Syndrome
Kidney
Biopsy
Peripheral Blood Stem Cell Transplantation
Paraproteinemias
Melphalan
Subcutaneous Fat
Amyloid Plaques
Prednisone
Serum
Cardiomyopathies
Dexamethasone
Creatinine
Bone Marrow
Urine
Proteins
Therapeutics

Keywords

  • Amyloidosis
  • Multiple myeloma
  • Nephrotic syndrome
  • Stem cell transplantation

ASJC Scopus subject areas

  • Nephrology

Cite this

Immunoglobulin light chain amyloidosis and the kidney. / Gertz, Morie; Lacy, Martha; Dispenzieri, Angela.

In: Kidney International, Vol. 61, No. 1, 2002, p. 1-9.

Research output: Contribution to journalArticle

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